<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32037

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMALLLEGDSMNVDGTMQGLEGIEGMQGIQGMEGMEGMGGMEGMEGMEGLGSMGSAMALEEVDLFGDPVMDDALAGLPPRPLVSKSLLQRLDDLRVRGCCQGIAWSRQGTIATIAKDAMSVELRFIRSHPRYHRMGPQRAKFMLRIVRVGIQWGLPQVDKQVLSQSQPLRPSLRESHVAVTSWVQYGSSESAVDASVSRLSHIEILPSAHTAQSQPMHPPVVLTVRSYVPQDASSYQQESQSIIDRWEVLSDQPQALVPAFEQLGSKNGNTSALPTLTHLRKLEPIILPKVVVAVTTTQFGRVLCFAFSDGTVQYRNRFTMDEIYNELNTDSIMHPLQVGFHFVNDTPCLQVAFSPTNCSFVQIGEDSAIKWNRLHHPMENSETEFKNAIARPFAQFPDFASSWVKETVNMLKIVVDYSENTHHEQLVKNVPLQHCLSVINHLGFHGDFRPRSHGGKFAMLALSVKGAFLVITVASNSPIGTKEKLIPLDDPDVVDAVTGCTAWGISLLAWLSDSLFELLDDPEITAMLSGPKRFPELAKYLESKNNVALQLLLCSSTRGFLLALCRRLQHIETVSNRAAQYYETRFQQQQDPASGGAAPARPHPALSRAYQRMERVISSALVKVSEFERLLSDLGSDIQRYHNLLELKGQPPRPLAARKASQQPGGSGVPPPFAGNSSSSGGSGGSGMLPAGDNGMASYRMTIVGTWTGIGGGQRRSAVAPIVEVVKEQGEDREEEEVKEEKEEEEERVEEQEEGGIGCGILRSG
Length765
PositionTail
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.06
Grand average of hydropathy-0.254
Instability index48.78
Isoelectric point5.54
Molecular weight83823.34
Publications
PubMed=25720678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364149
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32037
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.91|      16|      16|      16|      31|       1
---------------------------------------------------------------------------
   16-   31 (31.97/16.94)	MQGLEGIEGMQGIQGM
   34-   49 (32.94/17.65)	MEGMGGMEGMEGMEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.12|      13|      15|     654|     668|       2
---------------------------------------------------------------------------
  654-  668 (19.57/16.68)	PLAARKASQqpGGSG
  672-  684 (25.55/13.89)	PFAGNSSSS..GGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.81|      42|      45|     164|     205|       3
---------------------------------------------------------------------------
  164-  202 (60.12/32.46)	.........QSQPLRPSL.RESHVAVTSWVQYGSSESAVDASVSRLSHI
  203-  246 (55.83/29.67)	EILpsahtaQSQPMHPPV.V...LTVRSYVPQDAS.SYQQESQSIIDRW
  247-  279 (42.86/21.23)	EVL...............sDQPQALVPAFEQLGSKNGNTSA.LPTLTHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.36|      25|     453|      62|      86|       4
---------------------------------------------------------------------------
   62-   86 (45.17/26.66)	DLFGDPVMDDALAGLPPR.PL.....VSKSL
  490-  515 (24.79/11.45)	....DPDVVDAVTGCTAW.GIsllawLSDSL
  517-  541 (36.39/20.11)	ELLDDPEITAMLSG.PKRfPE.....LAKYL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32037 with Med16 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVAPIVEVVKEQGEDREEEEVKEEKEEEEERVEEQEEGGIGCGILRS
2) LELKGQPPRPLAARKASQQPGGSGVPPPFAGNSSSSGGSGGSGMLPAGDNGMAS
718
645
764
698










Molecular Recognition Features






MoRF SequenceStartStop




NANANA