<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32036

Description Uncharacterized protein
SequenceMDAGTKKSSLSTSITAWSTFLQRVLVKRLDQDRFADLIPIHFDRFPLPAVIVADELLRPAERQRYCLDPRIHLYLDALLKQHRVDPAAVLRALLKYSSAHSKVQPPDADTPAGDGVEKGKGGEGEGQQVRKLIRWQNSYDDEERIFWRLAQAVHHKSGIRTVRNVVQVAKMLAKWARMFAEAAAVFSREAFGSIHGLQARDELADARTAFVLLLIAFSENRLARLTLSQAGSAKIPEIPLVNSRAGLYIYLSAAISASFDLLANAVFRNEGPKTGHLLKSFVVNKVPLILVSLTNSPTMYPFNSEMCIKEALAQVDTNVFPTLSGMFEMSNTNSSFHDSVRQDFCFSCQLHGLLSQTAIENLLGDITYQSLPDEGRYVKDNLVQACLLDVDRTQRLIGELDNMNGNVGAAAQAIIELCSQLAAKPLALDVLLLFDKPQKILHPLCDLLDNWGGYDEDQGEYHPVYEEFGSILILLLAFVYRYDLSPADLGIRSPDSFVGRLLGGGNRCRPLEGLNEQEKAHLNGWVHGLFDTDAGGLGDDLMALCTPQDFYLLMPTLFHQIVVGLSAGYLTDDVLKGGLEYAIGHHQDTPDHHTAELHVQRGSYHALVGAQHRGQAARIRTAVLPAARSQVSGGRASPPSHQGEPRAIPPNGRCGPHRARVLPRTFIQWAQHPPLNGMPATYTHRQTLATVKILGAKHLLAILLDELKASTDLSQASIAYDVATALICAPDVTNDPSLAPPPSQAAISTTTPQITGPDDPAAPPPPQRDISLRDALKAEADDWKKIRKTDPALAEVIVRLYRRVEAQMTPPPPSDAEAAAAAAAAAAMLQPELGDVGVLGDAIAAAAAVAGDHHHHHHGLHGHHEGMMMDAGGLEAELGGLGGGGGGDGVAGGSGLDADGLFGGLSTGNELLASPHHVLVMSPRNVVGVGSCVPQQRRIQVHFPLGYLFLSRIQHGSPGSNLKPDHLPNLALLSIFSLPPVQRRDSANCHCHAAARDPAPPTFLASVPSKPPSANNTGLSHEKTGPNVQLGAESGTTEPHAASAQNRDAAVALRPVPGSPVNYYGRSILVDLGRDLPQSSFVLLSWSATANTLVRAVLQARDSTDNTCGYVSGIPTSSLWCAETAQCVYNSLNSHIGCCDDTTTNCPVWTTCYDSTDRESFTTDNGLTLWCGSSSFPHCYTHIYQDSNIIKGYSLLGCAVAAGTGQVWYSSTPTRSSTTSISDLTSTTSDEPTSTTTISSSATTTALPLLAESSTNIGAIVGGVVGGVAALGLIGLGVWLLMRMNNKQKKKDAATAAAAAAAGTQHHQQQPPPHPNNGGDPHMSQLPPHQQHHQQQPPYYGAAAANTTNPGYGKLHHSVAYSTTTAGGYDQSTIVGSSPPGSPPLSGPYQNIQGTPSPPPQQQQHQPQQQFGQFAGFGEQQGQQGYGQQGQQGYEQQQYGGGSPGAVSPGTQVGYGQPQGQGQQGGHGYVAELPAQRGDGELRELGDSEPASPPLGVWMLLTQAVRHKMVDGPRIQQSWVQLVQAGHTAHLHSRHQFVVEYYLHHRRRGIQTPAPMIRQQYPIRPGLHRAHRVGCRLDALDYERRVGGQVAPQPGDGGGPGEGGRDVGGHESAEGRAVRVGGGGDLRGHGGGGFGGGGHALVGFALAGNGGVDGEEDAFDLGPVVGVAGRGEGVQQGFGVGGVLVDVELEEDGDAVRVWPGRGRVVERGLHHVRYGEARARADDLGDAAEFSAGPRYLALALRVDGLAEGGGRDKDRGGYALAENCGCQRYRRGDVNEHTRAEGDLGIGGTVAAINITRWHQITLKPLWESVTVTSKKEVQLYRNNAARLPRGRLQFTEELCLDAEFYCYAIKGRCPHGIHHWNWIDQDAPGDRTRPFDRLALAAESVLEQFRDSPLKSFRNEGVELEVWCAKFFGLTTQQPSRLIFPVIRELSLTDVPLVAAMAHAVNFGTLRSLTLLRCRGWYVFLVWAIELKLPIRLKTFGIHIIDDAPYGSNRIIIEAFLSSFKGLEDLFIDEPERQGLLLFWDDVACHQPALKKFVHQQRTWPSDRSAFSSARVVPRPPLLNLEMLQLQRGPFATQLRDLDLEFVGLPCRPMLLVPVLSLYTRKTSLKVLHIPASSGCRDEIAAASLFRSGLRSEFRDFAEWVFGPHRIDSLRFLVFGDYSFGGRKCDNRLILCRGPMPVKKSNFRILARSGTDVHHLDKYRDALRACPTHAFFDGVFGL
Length2225
PositionTail
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.07
Grand average of hydropathy-0.258
Instability index41.37
Isoelectric point6.48
Molecular weight240434.63
Publications
PubMed=25720678

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32036
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.45|      18|      23|     727|     748|       2
---------------------------------------------------------------------------
  715-  743 (20.61/16.64)	QASIAydvatalICAPDvtnDPSlAPPPS
  744-  766 (33.85/15.90)	QAAIS..tttpqITGPD...DPA.APPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.62|      23|      23|    1305|    1327|       4
---------------------------------------------------------------------------
 1305- 1327 (48.24/22.60)	QHHQQQPP...PHPNNGGDPHMSQLP
 1331- 1356 (34.45/13.75)	QHHQQQPPyygAAAANTTNPGYGKLH
 1404- 1424 (30.14/10.98)	QHQPQQQF...GQFAGFGEQQGQQ..
 1452- 1474 (36.79/15.25)	QVGYGQPQ...GQGQQGGHGYVAELP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.71|      21|      23|    1628|    1650|       6
---------------------------------------------------------------------------
 1628- 1650 (33.77/21.03)	GHgGGGFGGGGhALVGFALAGNG
 1654- 1673 (32.07/11.66)	GE.EDAFDLG..PVVGVAGRGEG
 1677- 1693 (23.87/ 6.50)	.....GFGVGG.VLVDVELEEDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     221.54|      39|      47|     979|    1018|       7
---------------------------------------------------------------------------
  649-  683 (56.53/27.23)	PP......NGRCGPHRA....R.VLPRTFIQWAQHPPlngmP.ATYT
  934-  961 (38.82/17.72)	.PQQ.RR..IQVHF.........PLGYLFLSRIQHGS....PGSN..
  979- 1017 (76.51/41.09)	PPVQ.RRDSANCHCHAAA...RDPAPPTFLASVPSKP....PSANNT
 1026- 1064 (49.68/22.56)	PNVQlGAESGTTEPHAASaqnRDAA..VALRPVPGSP......VNYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.91|      33|      49|    1695|    1727|       8
---------------------------------------------------------------------------
 1694- 1726 (59.33/27.63)	DAVRVWPGRGRVVERGLHHV..RYGEARARADDLG
 1727- 1748 (34.21/12.88)	DAAEFSAG.PRYLALAL............RVDGLA
 1749- 1777 (45.37/19.43)	E......GGGRDKDRGGYALaeNCGCQRYRRGDVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.30|      26|      49|    1102|    1127|       9
---------------------------------------------------------------------------
 1102- 1127 (48.38/27.29)	D.STD.NTCGYVSGIPTSSLWCAETA..QC
 1133- 1152 (38.81/20.40)	N.SHI.GCCD..DTTTNCPVW....T..TC
 1153- 1179 (29.11/13.41)	YdSTDrESFTTDNGL...TLWCGSSSfpHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      20|      23|     806|     826|      10
---------------------------------------------------------------------------
  806-  826 (33.66/22.62)	AqMTPPPPSD....AEAAAAAAAAA
  827-  850 (30.41/15.24)	A.MLQPELGDvgvlGDAIAAAAAVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.03|      19|      45|     387|     405|      11
---------------------------------------------------------------------------
  387-  405 (33.67/15.82)	LLDVDRTQRLIGE....LDNMNG
  431-  453 (31.36/14.30)	LLLFDKPQKILHPlcdlLDNWGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.25|      57|     119|    1847|    1911|      13
---------------------------------------------------------------------------
 1847- 1911 (95.81/83.44)	FYCYAIKGRCP.....HGIHhwnWIDqDAPGDRTRPFDRLALAAESVLEQ.FRDSPLKsfrnEGVEL...EVWC
 1967- 2032 (88.43/54.59)	FLVWAIELKLPirlktFGIH...IID.DAPYGSNRIIIEAFLSSFKGLEDlFIDEPER....QGLLLfwdDVAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.94|      17|     217|    1276|    1292|      16
---------------------------------------------------------------------------
 1276- 1292 (31.56/22.48)	LGVWLLMRMNNKQKKKD
 1495- 1511 (31.38/22.31)	LGVWMLLTQAVRHKMVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.61|      13|      16|    1213|    1228|      17
---------------------------------------------------------------------------
 1213- 1228 (15.44/19.15)	PTrsSTTSISDlTSTT
 1232- 1244 (24.17/14.26)	PT..STTTISS.SATT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.51|      11|      26|    1534|    1544|      18
---------------------------------------------------------------------------
 1534- 1544 (21.40/12.69)	RHQFVVEYYLH
 1558- 1568 (22.12/13.39)	RQQYPIRPGLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.27|      33|     276|      62|     107|      22
---------------------------------------------------------------------------
   62-  107 (43.27/57.06)	RQRYCLDPRIHlyldALLKQHRVDPaavLRALLKYSSAhskvqpPD
  341-  373 (61.00/38.97)	RQDFCFSCQLH....GLLSQTAIEN...LLGDITYQSL......PD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32036 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVTNDPSLAPPPSQAAISTTTPQITGPDDPAAPPPPQRDISLRDAL
2) KKDAATAAAAAAAGTQHHQQQPPPHPNNGGDPHMSQLPPHQQHHQQQPPYYGAAAANTTNPGYGKLHHSVAYSTTTAGGYDQSTIVGSSPPGSPPLSGPYQNIQGTPSPPPQQQQHQPQQQFGQFAGFGEQQGQQGYGQQGQQGYEQQQYGGGSPGAVSPGTQVGYGQPQGQGQQGGHGYVAELPAQRGDGELRELGDSEPASP
3) PPTFLASVPSKPPSANNTGLSHEKTGPNVQLGAESGTTEPHAASAQNRDAAVA
4) RVGGQVAPQPGDGGGPGEGGRDVGGHESAEGRAVRVGGGGDLRGHGGG
731
1290
1000
1585
776
1493
1052
1632










Molecular Recognition Features






MoRF SequenceStartStop




NANANA