<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32035

Description Uncharacterized protein
SequenceMAENGKRQSREGDDSNMEKAEEKREKSVSDSSSTAGSVHVAKVEKESALADSDHDQSTSAHPDGGFSSSDFDTEEAKVAVPGHDLDVELAQVSSPFTATMTPWSLSSIPETDHSPDPQHHGTAAELSRSNTRNSTRSRISRIISRKRTVERERIPHAPIPLSNLDEGVVGWESQDDPAMPLNFPSRKKWLIVGLLSGITLLTPFASSILAPGISNLSKEFGNTNQVIGAMTVSVYLLGYVIGPLFLAPLSELYGRRPVLAVANVFFCLWLIGCALAPSIESLIVFRFFSGIGGSGCLTLGAGVIADVFRTDQRGSAIGMYTLGPLIGPTVGPVLGSWLSQTIGWRWDFWIVFIISVIVVGLFELFTTETNPRILIKHKVARLQKELNRTDLRSCYDTPGAEKQTPTQTLINGLIRPTKMLFLSPTVFFISLYLAFAYGTLYLLFTTIPTVFQQTYGWSVGITGLVYICLGVGNVSGWAVITATSDRGVVKRTRANGGVFEPEMRLPLSIYFSFLLPVTFFWYGWSTYYRTHWIVPVLGLFPFSFGVIGIFLPLMTYLVDSFPVYAASAMAANTVFRSLVDNLHPNRCMPVFVQLCCLTSGLLTPRCAAWFCKSGMGRTHLQAPRQAGQKPSLPSKYRVMNKTSPSTGTSQSSMQISPIWRSLPDDLAEQVFALHVNTHFFTDPAYTWTQLRQLSAHQKRVIELRFRAYWLPKLSISLYASASHRFDYGMDEAAQQTTTTTTATTATTASLGDDGSVVFSMQRQVHSPLVGISQDLGLGRYTRTYLRKAWVMYNRVEYRNVTVRLGEGVLSGGCRGGYILNDTHLPGVELLEGGGIRFDWKGAVDELLREEMYMRREGEKMFDAACEEWLANNPQHLPGTDKEKRGSPPLNIQATSKWLHGQEPDYVPLDAVRRWLFVACPREQPPDIFEVAEVEESVVPMMQIFQTWVRQQPCAAENDLEKASRDDDMVPTHTIIDLYRKEFAWRAWIRYSKRDEHDDRRLDEDTDDEFMDCGQNWTGPQALLLGDEKVRHDVNIRESPKQRKNILIAEIKTSFRDLVNHTAAPVDSTAWTGQTAYNSLAMGAKMSSIIKSTEDLLSLTRKVRELWLIGALKPPGAQDAAAEQAMQQDAEQVFAMLNALRDRQRQAMLQQAPGGGFTYEQGAVDGPAPPHQPSQPQPQSQPENGVSQGPAQALPNISNGQAQQQQPAGALPRPSVQQL
Length1218
PositionHead
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.09
Grand average of hydropathy-0.223
Instability index46.12
Isoelectric point6.31
Molecular weight135197.18
Publications
PubMed=25720678

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
transmembrane transporter activity	GO:0022857	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32035
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     321.47|      66|      78|     406|     471|       1
---------------------------------------------------------------------------
  236-  301 (72.01/44.10)	.............LLGYVIGP...LFLAPlSE.....LYgrrPVLAVANVFFCLWLIGCA..LAPSIESliVFRF.......F........SGIGGSGCLTLGA
  312-  391 (50.87/28.60)	QRGsaigmytlgpLIGPTVGPVLGSWLSQ.TIgwrwdFW...IVFIISVIVVGLFELFTTetNPRILIK..H...kvarlqkE........LNRTDL.......
  406-  471 (112.77/73.97)	TQT..........LINGLIRPTKMLFLSP.TV.....FF...ISLYLAFAYGTLYLLFTT..IPTVFQQ..TYGW.......S........VGITGLVYICLGV
  481-  546 (85.82/54.22)	TAT..........SDRGVVKRTRA...NG.GV.....FE...PEMRLPL...SIYFSFL...LPVTFF...WYGW.......StyyrthwiVPVLGLFPFSFGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.51|      26|      49|     803|     828|       2
---------------------------------------------------------------------------
  803-  828 (48.11/26.87)	RLGEGVLSGGCRGGYILNDTHLPGVE
  855-  880 (50.40/28.47)	REGEKMFDAACEEWLANNPQHLPGTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     339.50|     108|     120|     897|    1009|       3
---------------------------------------------------------------------------
  897- 1009 (179.48/115.88)	WlHGQEPDYVPLDAVRRWLFVACPREQPPDIFeVAEVEESVVPMMQIFQT......WVRQqpcAAENDLEKASRDDDMV.PTHTIIDLYRK.EFAW..RAWIRYSKRDEHDDRRLDEDTDDEF
 1016- 1133 (160.02/89.29)	W.TGPQALLLGDEKVRHDVNIRESPKQRKNIL.IAEIKTSFRDLVNHTAApvdstaWTGQ...TAYNSLAMGAKMSSIIkSTEDLLSLTRKvRELWliGALKPPGAQDAAAEQAMQQDAEQVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.86|      14|      16|    1187|    1200|       7
---------------------------------------------------------------------------
 1187- 1200 (27.29/15.67)	QGPAQALPNISNGQ
 1204- 1217 (27.56/15.91)	QQPAGALPRPSVQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.98|      12|     318|     832|     844|       8
---------------------------------------------------------------------------
  832-  844 (19.47/16.68)	GGGIRFDwKGAVD
 1153- 1164 (24.51/13.91)	GGGFTYE.QGAVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.34|      16|      87|     567|     582|       9
---------------------------------------------------------------------------
  567-  582 (27.31/17.48)	SAMAANTVFRSLVDNL
  651-  666 (31.03/20.93)	SSMQISPIWRSLPDDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32035 with Med22 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATMTPWSLSSIPETDHSPDPQHHGTAAELSRSNTRNSTRSRISRI
2) DRQRQAMLQQAPGGGFTYEQGAVDGPAPPHQPSQPQPQSQPENGVSQGPAQALPNISNGQAQQQQPAGALPRPSVQQL
3) MAENGKRQSREGDDSNMEKAEEKREKSVSDSSSTAGSVHVAKVEKESALADSDHDQSTSAHPDGGFSSSDFDTEEAKVAVPGHDLDVELAQVSS
98
1141
1
142
1218
94










Molecular Recognition Features






MoRF SequenceStartStop




1) QALPNI
2) QSREGDDSNMEKAEEKREKSVS
3) VHVAKVEKESAL
1191
8
38
1196
29
49