<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32034

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMNNRPFSLQPRSAPQQGPQSINEFIQRLNAEPGGFRAVNSAELRREIEASQNGTDGDNDVDMTGDVSEDESDSPEIKSIAVARDEILRAIHQTHQTSMFALDFISLLLSKENPGLAVTTLSPGLRDLVGIGTLGATMLDAPTPMTQSRVSDHKMVAIGKRLMDLNKAADTALATSKRLQREITLETKYWSEVLGVGDAGWQTFRLPHEPQTLGVKFGFSNTGPEFKNSGIAPLRRAEDGSVKLEHGAMDGGSKRLQVKILENGVVVGRSSLPQPIPPDAPLEDRVKESRETVFAQELWHEINREARDQLDGLATVADSTATYNLDNTTTIALQLVTLGNEEEATTQRSAAQDAFANELCTILGLLLTNAHRANDLKRSEPSAKKGSIPPYFLLRPLITYHKYGQSVQQCAESLTALISVLRSAGVASSITMKEAPLRPFLDNTTPASTSLATLLLKPPTVQFDLTITPASRLRILLRPTLLSGAAYAVSFLPPLQQQQPPNSPANPLPAVCPTSPEDYTDPAKLLAYLYAAVPCALAAAYYELAITQQQQQQQQQQSSPTLDEQVQSQDQTQSQDAEALWGMHPQGNGIVDLATGGDYGVHFGLERDAATGRLELTVEGDYVEVEVEGGGGGGGVLPTEIGNEMDIKKEGMEDGGVGEGVGGGDNEGEGKGEGRKGDDGPERRKVHMEWRWPGTMDAVGAVTKQVLSNGPGNE
Length713
PositionHead
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.05
Grand average of hydropathy-0.427
Instability index53.48
Isoelectric point4.86
Molecular weight76736.98
Publications
PubMed=25720678

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32034
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     110.52|      19|      20|     580|     598|       1
---------------------------------------------------------------------------
  580-  598 (35.11/17.96)	WGMHPQ.GNGIVDLATGGDY
  602-  621 (24.72/10.48)	FGLERDaATGRLELTVEGDY
  630-  644 (25.06/10.72)	GG.....GGGVLPTEIGNEM
  661-  678 (25.63/11.14)	GGGDNE.GEGKGEGRKGDD.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.24|      35|     147|     162|     241|       2
---------------------------------------------------------------------------
  175-  215 (48.51/85.43)	SKRLQREItLEtkywSEVLgVGDAGWQTFRLPHEPQTLGVK
  252-  286 (61.72/16.76)	SKRLQVKI.LE....NGVV.VGRSSLPQPIPPDAPLEDRVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     232.81|      51|      53|     453|     503|       3
---------------------------------------------------------------------------
  364-  408 (40.22/26.34)	....LLLTNAHRANDLkrsepsakkgSIPP....YFLLR..P.LITYHKYGQS....VQQ......
  420-  448 (37.09/23.59)	......LRSAGVASSI..........TMKEAP.LRPFLD..NT..................TPAST
  449-  502 (82.38/63.36)	SlatLLLKPPTVQFDL..........TITPASRLRILLR..PTLLSGAAYAVSFLPPLQQQQPPNS
  503-  557 (73.11/55.22)	PanpLPAVCPTSPEDY..........T.DPAKLLAYLYAavPCALAAAYYELAITQQQQQQQQQQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32034 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRAVNSAELRREIEASQNGTDGDNDVDMTGDVSEDESDSPEIKS
2) QQQQQQQQQSSPTLDEQVQSQDQTQSQDAEALWGMHPQGNG
3) VEGGGGGGGVLPTEIGNEMDIKKEGMEDGGVGEGVGGGDNEGEGKGEGRKGDDGPERRKVHMEWRWPGTMDAVGAVTKQVLSNGPGNE
35
548
626
78
588
713










Molecular Recognition Features






MoRF SequenceStartStop




1) INEFIQRL
2) PERRKVHMEWRWPGTMDAVGAVTKQVLS
21
680
28
707