<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32033

Description Uncharacterized protein
SequenceMRLVESTSAAESKVFIPSRIMPPTDSSELGDMSPHPSIHPLSIEADVPLPLPQRPPPFVASVPRREMPPPATANPPKKDNRPKPYTVEPPAAAPRYAIHTDAQVKAGGSAPKIGYADFFPWTGNHPEDQFSDDVIRNGYYNKALYTPAETQSAKNILFPALKHKTGLTALSSVFTAVLGQRRHNGQITAPSTFKPPPRVTLTDTKRESWLKDLANPAISLRRLSRTIPHGIRGKILLEQCLNKRVPTDRAVWLIKTRLAAHLYAEYLLDREHFSEWLVSNLENSSDAKLPMWMLITQLYWKDLLKMRRYGRRLVTALISHHHLIYNHPDKDILHPLLESLTQCLNTLILSSPENFVSPSTWSKYRDALKACLPAGDQARHNSFGAINLRNEQLAAAANRSQPAARHILVRMLDGTLQNPMSNELPAQCWGISKDKDALARALLEWCTSLYRPGLAKIYVTSRILQHWSTLGLDSTATVLDFLEADACEEKEHKSAFYHVVCELVRSEIFSVPRYIQWLMARGGTRNPELVSRDGPAPTRLLVEVPTHALAPSQRDLRGEMLRRASFSVADAAADVELALKHLKHTLGMSTDPTDLKPLSLSKFTKKIASADRALKAELGWWLRANFAAHAEEREREGNQAPEISPALFYAVRSVLEAAEDFSMIWRYL
Length668
PositionKinase
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.08
Grand average of hydropathy-0.346
Instability index52.50
Isoelectric point9.23
Molecular weight74919.07
Publications
PubMed=25720678

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32033
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.58|      34|      43|      60|     102|       1
---------------------------------------------------------------------------
   16-   44 (29.62/ 9.03)	.IPSRIMPP...TDSSELG..DMSPHPsiHP..LSIE........
   61-   94 (68.16/43.64)	SVPRREMPP...PATANPP..KKDNRP..KP..YTVEPP..AAAP
  510-  551 (39.80/13.10)	SVPRYIQWLmarGGTRNPElvSRDG.P..APtrLLVEVPthALAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.10|      24|     105|     258|     283|       4
---------------------------------------------------------------------------
  258-  281 (42.45/32.01)	LAAHLYAEYLLDREHFSEWLVSNL
  294-  317 (41.65/24.19)	LITQLYWKDLLKMRRYGRRLVTAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.21|      33|     196|     152|     187|       6
---------------------------------------------------------------------------
  152-  187 (48.87/45.28)	SAKNILFPALKHKTgLTALSSVFTAvlG.QRRHN..GQI
  351-  386 (53.34/36.90)	SPENFVSPSTWSKY.RDALKACLPA..GdQARHNsfGAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32033 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ESKVFIPSRIMPPTDSSELGDMSPHPSIHPLSIEADVPLP
2) PQRPPPFVASVPRREMPPPATANPPKKDNRPKPYTVEPPAAAPRYAIHTDAQV
11
52
50
104










Molecular Recognition Features






MoRF SequenceStartStop




NANANA