<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32028

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGDYETNNLLISNLSAISFRIYEPIAAQSSTYTFNASGVEDALRSDGHLVYMDAVRRGIWCFYLSSGDSAAPSHSERLGLHARMEVCGYPLGLVGDGNLEPIGLLKNRPPGTNAINTPNSSSSASSALDMNSRANQPFSFPPTPVVVDGKVASTPVGDVKGYGSVPAQEIHEFFITAVLSSLTSSFCRNVGAILLNNRSALLPPQVFNPGSLVIALHVSVLHGLVSSADVLRSSLLHAGPTVLAAPFGTFGAFQSVVDTENQVADGGYGQSPETQVSRFRSDHSDKFVQLKTTCCKLLQMSGMSPSLLDGCSWLNIHFLQKKPFEQRADGKRTPLVGPSSTAPWPAVLCFRKPKIEAMLDVPLEKALAGTGVDHLDPLDKAKVWCQGVIEREDAAIRRKRERDAASARELAEPDVRGHAQTNGYSPMALWRGSANGAPPPATGTMYPTPPDGVQMSGVTPSFDGGQVQSPAGQPLTNPAADGHAAMRQDAPVPDTFNATWNGAEPRPEPATANFAEDNLFGDLGEDMFEGNELTEADFNFFDEHPDSGAMDLSDLPELESSAMAIQENGNHQFEEQPPAAHGVEDEMDAPSVSPQFTKPELRHARSTLADENRQQTNMESFNRNSIAGIKRNPSPFNPETVFKRLHTRRSPLILSTQRGPLRRRSLFEKVNFDPALSPATKKYEKGPFDYTSTVRKEKRGGTLQNGSLLTAGRPLGSARQRRNLKELPPDIGCLVARIANVAPNGPKQQDDARSESGDSSSASLDEDASDQIGHASSPTKSSVVRRRPEDDVISMAASFRELENISVDSPGYGPVDLSRLSNSEIPDFSLSRYFADPEPAPLRISVSDDDFITVAQILTEQAASGSLKLAPQHQSSEVQDLRRSLIKAIRYSIKGLHKALPRSLSGAVGCRLRPFTEVQDVPLLVQPNARVQVRPAEFPKPSIFLIPTPHVEIRRYENQLSVLPSAVTFWDTLGLGPVQGPKSVVAVCIFPQTEGMRDNASAFLDRVQSTYESLKLGAFERLPTIANIVDGLVLLPTDHDIASPALNSPRARSAYTDQMTNLAMSLAGLSMSEKNFVVYFAYTPGNPSSIVDCCSAFQELFEHYKRCMMDKKKQISNDLALQLVPLDAVASETSLVVLSPSECTKLCLETYDRCTLFGGPMPSPAVMLERALPRGIDFKLAATPSPNLLRESSCIHVAYARSVDERWVTAAWTDNRGSTQSMASYCLGRRGKPLSRILADVIHEIWETTHGLISTCKVHWRVVITKCSPMEQHEMELWTGLAQSEARATVSLVLLTTDTDPSLQLIPPITTIPLSAPSAFYTTPVSTPQPFSVLSPDQSGNPSTPMGTTGSGINATTPGGDSSQQQQQQLPSQPNQPDTDGGDTTLIDTTETTWGVVVSHRLNNSASLTDLNPALASGYLVKRAGPRPEDAPVAMEVNVVYSDNARAMYDVILREMLAYFRGLGTLARVRGVTERDVDVRPWHVAVAEKAVRALYLLM
Length1500
PositionKinase
OrganismChaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) (Soil fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.06
Grand average of hydropathy-0.303
Instability index52.84
Isoelectric point5.56
Molecular weight162638.46
Publications
PubMed=25720678

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32028
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     289.23|      78|     103|     158|     246|       1
---------------------------------------------------------------------------
  158-  238 (119.40/74.05)	VGDvKGYGSVPAQEIHEFFI..TAVLSSLTSSFCRNVGAILLNNRSalLPPQVFNPGSLVIALHVSVLHGL...VSSADVLRSSLL
  265-  338 (119.13/72.09)	VAD.GGYGQSPETQVSRFRSdhSDKFVQLKTTCCK.....LLQMSG..MSPSLLD.GCSWLNIHFLQKKPF...EQRADGKRTPLV
  622-  668 (50.70/22.70)	...............................SFNRNSIAGIKRN......PSPFNPETVFKRLH.TRRSPLilsTQRGPLRRRSL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     371.62|     100|     322|      42|     154|       2
---------------------------------------------------------------------------
   42-  143 (173.10/81.35)	EDALRSDG..HLVYMDAVRrgIWC.FYLSSGDSAAPSHSERLGLHARMEVCGYPLGLVGDGNLEPIGLLKNR.....PPGTNAI.NTPNSS...SSASSALD...MNSRANQPFSFP
  366-  480 (149.11/64.56)	EKALAGTGvdHLDPLDKAK..VWCqGVIEREDAAIRRKRERDAASARELAEPDVRGHAQTNGYSPMALWRGSangapPPATGTMyPTPPDGvqmSGVTPSFDggqVQSPAGQPLTNP
 1338- 1379 (49.42/15.31)	...................................................PDQSG....NPSTPMGT.TGS.......GINA..TTPGGD...SSQQQQQQ...LPSQPNQP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.98|      26|     637|     763|     797|       3
---------------------------------------------------------------------------
  763-  792 (40.38/30.64)	SASLDEDAS.DQIGhassPTKSS..VVRR...RPED
 1401- 1432 (31.60/10.21)	SHRLNNSASlTDLN....PALASgyLVKRagpRPED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.11|      16|      25|     502|     519|       4
---------------------------------------------------------------------------
  502-  519 (25.34/18.17)	WNGAEprPEPATANFAED
  530-  545 (28.76/13.86)	FEGNE..LTEADFNFFDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.19|      31|      39|     927|     965|       7
---------------------------------------------------------------------------
  929-  960 (51.56/44.77)	PNA.....RVQVRPAEFPKPSIFLIPTPHVEIRRyEN
  966- 1001 (49.63/22.09)	PSAvtfwdTLGLGPVQGPKSVVAVCIFPQTEGMR.DN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.93|       9|      22|     821|     830|      12
---------------------------------------------------------------------------
  821-  830 (13.09/10.47)	RLSNSEiPDF
  845-  853 (16.85/ 8.39)	RISVSD.DDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32028 with Med13 domain of Kingdom Fungi
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