<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32008

Description AAEL001689-PA
SequenceMSCEKDCDSSDATDLSASPLGHIKVCDQQQMLAKSGAPLSNQYLGSPSPDKFQQLANYQNHMKNLDFAASLDSAALAAATGHHQPHHPGLHPQHNTLPSHAELEYMKSLKENNKYFIDRSYRASLGQYGNNKYGGGGGGGPGSEDGNSTVNDYEDDLSSPTGVMATSGGGLKRKYSDNDDHLLDGSSGGAGSGADSNQVEGSINKYSKLHDSADKSIKANSFDYMKSFDDLRARQAAYDAEQQLQQHHHQQQQQQQQQLHQQALHHHHQQQTQAQLQQHNAQSQHPLQQQPPPHQQQQQQQQQHLASGSSSVHGQSAMATGEHRPDDYRLGAVSGGPGGGGGVVGQEGGPDKLGEDGGISYASSEEMNQTTSSEQGEKMGSGSDDEGGDDGCSKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLSHFSQLPHRLSCNGANLPVDPWLSPPLLSALPGFLSHPQGVYPSYLTPPLSLNPSNLGMTNLGLGHPNGPQNLRISPQGMAAMQQQMSGHNMRLSPPHPNGAIAPQNLSMAPQQPLTPRHSPLGGPAVGLGVPGQTHPSQPPPQLGSVNIPITSPQNLSLTPPGLRSPQSLSSSSTSNNNNPLTGHPLSPNSSAASSPTSSTGPKMSKLANFDHQPPQDGGSPLDEQQQRLLGAALGGAQDGPGNGTGSAGTALNMTVNHSTDMRTNSIASLRIKAKEHLENISKGMTTMV
Length756
PositionTail
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.04
Grand average of hydropathy-0.902
Instability index60.46
Isoelectric point6.47
Molecular weight81034.92
Publications
PubMed=17510324

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IEA:InterPro

GO - Biological Process
transcription by RNA polymerase II	GO:0006366	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32008
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     312.72|      43|      44|     541|     583|       1
---------------------------------------------------------------------------
   70-   99 (29.75/ 6.22)	.......SLDSAALA.AATGHHQPHH..P....gLHPQHNT.....LPS..................
  274-  304 (33.78/ 8.10)	...........AQLQQHNAQSQHPLQqqP.....PPHQQQ................QQQQQQ....H
  489-  516 (43.53/12.66)	......SPPLLSAL....PGF...LS.........HPQG.V.....YPS.....YLT..PPL....S
  517-  537 (33.50/ 7.97)	LNP...SNLGM.......T..NLGLG.........HPNG........PQ.....N............
  538-  580 (68.14/24.15)	..L.riSPQGMAAMQQQMSGHNMRLS..P.....PHPNGAI.....APQ.....NLSMAPQQ....P
  581-  630 (60.86/20.75)	LTP.rhSPLGGPAVGLGVPGQTHPSQ..P.....PPQLGSVnipitSPQ.....NLSLTPPG....L
  631-  688 (43.17/12.49)	RSPqslSSSSTSNNNNPLTGHP..LS..PnssaaSSPTSST.....GPKmsklaNFDHQPPQdggsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     172.47|      29|      29|     152|     180|       3
---------------------------------------------------------------------------
  131-  155 (40.76/16.09)	NKYGGGGGG...G....PGSEDG........NS...TV.NDY.ED
  156-  184 (42.87/17.31)	DLSSPTGVMATSG....GGLKRK........YS...DNDDHL.LD
  185-  214 (27.52/ 8.43)	GSSGGAGSGADSN..qvEGSINK........YSklhDSAD.....
  308-  331 (30.96/10.42)	GSSSVHGQSA.MA....TGEHRP................DDYrLG
  332-  370 (30.37/10.08)	AVSGGPGGGG..GvvgqEGGPDKlgedggisYA...SSEEMN.QT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.29|      18|      20|      16|      33|       4
---------------------------------------------------------------------------
   16-   33 (32.62/21.08)	SASPLGHIKVC....DQQQMLA
   35-   56 (24.67/13.85)	SGAPLSNQYLGspspDKFQQLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.09|      27|      44|     419|     445|       5
---------------------------------------------------------------------------
  419-  445 (47.77/37.32)	SHYPDVYSREELAMK.VNLPEVRVQVWF
  446-  465 (30.02/20.30)	QNRRAKWRRQE......KSESLRLG..L
  466-  488 (37.30/27.29)	SHFSQLPHR..LSCNgANLP...VDPWL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32008 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AALAAATGHHQPHHPGLHPQHNTLPSHAELEY
2) NPSNLGMTNLGLGHPNGPQNLRISPQGMAAMQQQMSGHNMRLSPPHPNGAIAPQNLSMAPQQPLTPRHSPLGGPAVGLGVPGQTHPSQPPPQLGSVNIPITSPQNLSLTPPGLRSPQSLSSSSTSNNNNPLTGHPLSPNSSAASSPTSSTGPKMSKLANFDHQPPQDGGSPLDEQQQRLLGAALGGAQDGPGNGTGSAGTALNMTVNHSTDMRTNSIASLRIKAKEHLENISKGMTTMV
3) QYGNNKYGGGGGGGPGSEDGNSTVNDYEDDLSSPTGVMATSGGGLKRKYSDNDDHLLDGSSGGAGSGADSNQVEGSINKYSKLHDSADKSIKANSFDYMKSFDDLRARQAAYDAEQQLQQHHHQQQQQQQQQLHQQALHHHHQQQTQAQLQQHNAQSQHPLQQQPPPHQQQQQQQQQHLASGSSSVHGQSAMATGEHRPDDYRLGAVSGGPGGGGGVVGQEGGPDKLGEDGGISYASSEEMNQTTSSEQGEKMGSGSDDEGGDDGCSKKKHRRNRTTFTTYQL
74
518
127
105
756
409










Molecular Recognition Features






MoRF SequenceStartStop




NANANA