<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32006

Description AAEL008244-PA (Fragment)
SequenceMWEKMNMRPLKRPRLGPPDVYPQEAKQREDELTSTHVKHGFATEHKLSEEFGTARNCNVTASKVGAYFNAILARKEELMTLPDSGRKKQQINPKDNFWPVTARNKATLDTWFKDLAGTKPLSSLAKKAPSFNKKEEIFAMLCENQVTMQRAAWFIKLSSAYTVAVSEAKIKKRQMPDPATEWTGTLIKFMKDLVPKLHEHYYQGPVPEKTSTGPAPGGMTPNSGLNSSLTIPAPMSSPAGSLHSPASSSVGSNASQMQNQPPPPSPQEEQKLAQKQWNYCTQLCKYMYEEGLLDKAEFLNWVLDLLDKMKSPPSSDDGILKIYVPLAMQYLSDFVQSERFSRRLAYAVCKKLAHLINKMSTESDIKTEDGSRENPFDSIFSEYMSCCHHRDLILQLSSIVQVITLECPTALVWCGIGETRSSSVLAGSPLDHLPVAPSGLPMPSRCEKSNEDVRKKLLQAEESIKIRSRHAESRWCIDKWQTAAGNASLKILTVLDALDGHCFDRMDTNNSLDTLYQKIFPPLQQRPKHQSEQAGPRFPCEQYHRDESIVKILCEWAVSWQRWGEHRAMAVAWLLDKRQNDVFTTYENESGNNANSSDDKDSVISGGGPGGGLPIFQNILMKFLDNDAPTLDEHGTQHNKSQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLLTGSGMSVLDVQSNCPGLVTGPISNKPNTSSPNVNQSMDEDVMQNDFKAKLEDLDDSNVDDDLDKLLQHIKEDQQNSMDAPDSPKDPEHTAPHANTVNNKSESSSRHFLYTEHFPLCQDDPISQHDCNQRYILLYGVGKERDEKKHAVKKMSKEICKLFSKKFSIDVAEGGKVKKHSRNEFNFESTSNKCQSMSYFDQHVVTWQCAVQVQEMLNSFALGNSNYLPVQEHVAFLFDLMESAFNIYSLIDTCIQILKELPEVELQLMSKNSVLTKNYTTSLGLYVVGVLRRYHCCLLLSSEQTIAIFEGLCRIVKHVTNPSDCSSAERCILAYLYDLYSACASLKTRPQQEQAFNNAYPKIKQALYTPLQPSPSAHLYNPQFMADVINSPKRGGKIEQSWARLLNESPSNRYSFVCNAVIAVTGDIDNDTLNDIAAMCAELTACCNALSTEWLGVLIALCGSSKDAGYYVDVVNQVNIKNTNIHNALSVFTSILVARHCFSLENFVAHVALPALVQACKGRSETTAEIEAGARLSCHLLLRLFKTIECPQPGLYSVSTSPNPITITGHVHNIKLSCDRHLLAAAHKNIGVAPVLAVLKGILVVGDATAQKAQSSIFGSERRSGLNTPVHPGSTPKHAGDLSHILGTSDLSVLGNTDESMLDLTQNNTNQETTTSLSDFAQHVLRQICSQEWVLERCLQNAEELCQPGMLIDNMLTAKQAQRLLHMICYPENESNLIAEMDQKAIIVRILENLEQWSLRISWLDLQLMFKQTNCSSPELSNWLDLVARAAIDVFQVYECNLIGSQTQNTASSKTKPSIWLVAPLVAKLPSAVQGRILKVAGQVLESTNMFSKSKESGSGNNSGLNNQDGNSNSSISSNGSIIAAKQSLQLNHQPFLGLVLTCLKGQDEQKEGLLQSLYTQLSQFVQNREIELVGGIEDPYGFEKMLDALQLRYSLVGGLFDSIQKNSTSTSDWAILFSQLISQGVIDLSNNSELFTTTLDMLATLIHSTLMSDSQSERDETKKQYTNLMKKLRKELGDKNNPSIKYVRQLLPIAKQTCEVIACEPAGSSIDAKGNKISIDSIEKKHGLRLADKQRVSVWDLLEGHKNPAPLSWAWFGAVKIERKPLAYEETHRLLKYHTHSLVKPSSYFYEPLPLPPEELEPLPDKIKDDMKADTPTSDQSPNPSGKKGKSQTRKRKQKGATTPQNQTQPGQGQVLPGQQQIGHQTGMAPGQQQPGHGPPQQQQQQQQQIGMTPQQTMQQLQNANINQMQMGNMNMNQMNPQHMQQQYQQPTQNQMMVQQMAQQQGVGPGGQSVSNQMGFVGTGTGGIGNQNVAGSNQPWAGYSSMQQQTPQQQQQQMFYNQNLGQPTMNRFDRPQLNTNPKQMLSNMLRARGVSPGAAGFMQQAQRNPQQPFMRGPIRPGMPNQMVGSGINAAAGGTMMGSGGSMIQTNLIAQQGSGMVNQGLGNTGMSGNALIGQAAGNSNASGMGNAGIMGMQNIQQSNNINAGMVNQGMNPGMGNPGMLGQGQGATNTGSLNNPNMMGMQNMPQGGMQSGMFQAQNQQLQQQQQRFRQQMLIQQQQGLAQQGNNQGMVQNQGQGMNQQQTPNLVAQLQRQMPNQGN
Length2291
PositionKinase
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.06
Grand average of hydropathy-0.503
Instability index49.67
Isoelectric point6.81
Molecular weight253517.51
Publications
PubMed=17510324

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32006
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     123.27|      20|      20|    1948|    1967|       1
---------------------------------------------------------------------------
 1922- 1940 (30.25/10.17)	G.MTPQ.QTMQQ..LQ....NANINQM
 1948- 1967 (41.63/17.01)	NQMNPQ.HMQQQ..YQ....QPTQNQM
 2018- 2043 (24.24/ 6.56)	QQQTPQ.QQQQQmfYNqnlgQPTMNRF
 2218- 2238 (27.14/ 8.30)	PQGGMQsGMFQA..QN....QQLQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     156.25|      20|      20|    2121|    2140|       2
---------------------------------------------------------------------------
 2121- 2140 (40.16/21.59)	N.LIAQQ....GSGMVN.QG.LGNTGM
 2143- 2163 (22.94/ 8.27)	NaLIGQ.....AAGNSNaSG.MGNAGI
 2168- 2188 (30.45/14.08)	N.I..QQsnniNAGMVN.QG.M.NPGM
 2192- 2211 (28.29/12.41)	G.MLGQ.....GQGATN.TGsLNNPNM
 2244- 2262 (34.41/17.15)	Q.MLIQQ....QQGLAQ.QG..NNQGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.35|      22|      22|    1871|    1892|       3
---------------------------------------------------------------------------
 1843- 1870 (29.75/11.22)	KADT...PTSDQSPnpsgkkGKSQTRKRKQK
 1871- 1892 (42.39/19.16)	GATT...PQNQTQP......GQGQVLPGQQQ
 1894- 1915 (35.21/14.66)	GHQTgmaP.GQQQP......GHGP..PQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.16|      12|      15|    1970|    1982|       5
---------------------------------------------------------------------------
 1970- 1982 (20.65/15.41)	QQMAqQQGVGPGG
 1987- 1998 (25.51/14.16)	NQMG.FVGTGTGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.65|      82|     238|    1267|    1358|       6
---------------------------------------------------------------------------
 1267- 1358 (122.46/77.24)	AVLKGIL.VVG...DATAQKAQSSIFGSERRSGLNTpvHPGST............PKHAGDLSH..ILGTSdLSVLGNTDESMLDLTQNntnqeTTTSLSDFAQHvlRQI
 1502- 1601 (117.18/54.84)	AVQGRILkVAGqvlESTNMFSKSKESGSGNNSGLNN..QDGNSnssissngsiiaAKQSLQLNHqpFLGLV.LTCLKGQDEQKEGLLQS.....LYTQLSQFVQN..REI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     193.61|      50|     241|     495|     563|       7
---------------------------------------------------------------------------
  108-  153 (66.99/27.24)	...LDTWFKDL...AGTKPLSSLAKKAPSF.....NKKEEIFAMLCENQVTMQRaaW
  509-  563 (88.48/51.01)	NNSLDTLYQKIFPPLQQRPKHQSEQAGPRFpceqyHRDESIVKILCEWAVSWQR..W
 1027- 1054 (38.14/11.02)	NNAYPKIKQALYTPLQ..PSPSAHLYNPQF...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.23|      38|     392|     213|     259|       8
---------------------------------------------------------------------------
  213-  259 (64.40/50.97)	GPAPGGMTP..NSGLNSSLTIPAPMSSPAGSLHspasssvgsNASQMQN
  606-  645 (67.83/37.34)	GGGPGGGLPifQNILMKFLDNDAPTLDEHGTQH.........NKSQFTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.03|      40|     241|     963|    1004|       9
---------------------------------------------------------------------------
  963- 1004 (69.02/54.31)	RYHCCLLLSSEQTIAIFE.GL.........CRIVKHVTNPSdcSSAERCILA
 1205- 1254 (62.00/40.90)	RLSCHLLLRLFKTIECPQpGLysvstspnpITITGHVHNIK..LSCDRHLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.26|      18|      20|    1093|    1110|      19
---------------------------------------------------------------------------
 1093- 1110 (30.60/24.14)	AVTGDIDNDTLNDIAAMC
 1115- 1132 (32.66/26.43)	ACCNALSTEWLGVLIALC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32006 with Med12 domain of Kingdom Metazoa
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