<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32002

Description AAEL014851-PA (Fragment)
SequenceKMTPQPLEQGGAVASFIPTGQEMAQRQNLIPLGRLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSASTRQLFIRLLALVKWANSASKVDKSAKIMAFLDKQSLLFMDTADMLSRMARETLVNARLPNFHIPAAVEILTTGTYSRLPSIIRERIVPPDPITTLEKRQTLQRLNQVIQHRLVTGNLLPQLRKFKIENGRVTFKVDHEFEVSLTVMGDGPNIPWRLLDIDILVEDKETGDGKALVHTLQVNYIHQLIQGRIVDSPDALAEVYNCLHYFCQSLQLEVLYTQTLRLMRDRLDDHIHVDEYIPGTKLTVSYWRELTNKDPKSELGYRLMIQTDQSDTTKQLAILHLPSIGTKEVDIADRAVRSELLSMERLLVHTVYVRSLARLGDLKTELQLFLKDVDYSIQGTPAMLLVPVLNPCLRAEHIYITVDTHTGMLRCHVPKHLDCPIMPELQHALNNDRSKLQHLFSELRYWITQRRCEKTLQHLPATTQERLPLVFPADHPIEKIGPHRVYIQMCRHANVILIVELKEKESSPNEMTYTFYLVLVKPSSMEDSQSVTAGGTSQSSAPSAAATESDGMPKMYLKVLSLIEFDTFVATHGPGTYVDEQTVGSKRKLLTGEGPSAKQSKTIYPAYFIPELAHVVAMCDEKLPFVALAKDLTRRKIPHGGVQVEANATSLVLKLLTLPQPKPPVIPVSSSAAAAAAAQSGPDQKPPEPKVVSVPKIDKDVWNALLKRLLSVSVRAQINKSIQTRMWTVELVFYGTPLASAHHKEQGMRRAVYLTYDMLPVDSVDKFVDMILNDWSKIVYLYTLVHDFREQIKNDKYNLHNIVTIKSYSYTSLLLAYGPNKEVNVNIYWDTEAKEFKMVFTGGNNAINAHSMMRDQLQAHLNHNYDLAQIVYLLHETYQPLSSIAKLPIIPHLAILQSPKIPVLSFCIIPQSPTLLRISFQGVYCLEVRLRGSGLCSIRDGAYSRFDRSHVVEEFTPTQGLKGFLSKYVDETAVYRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGAMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGIGGSQSHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAAHSPGPTNLPYMSGHTDSPFSAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQSRFMAVSTSTEPPHHNTSRVLPARSWAGAIPTLLTHEALDTLCRATIHPQKEIPGPELSPLERFLGSVFMRRQLQRIIHQEDNLTAITSNEPGVVLFKADNLQYQVFLNPNHMQSLHMKVSQAPMAPTMDGKPPYQWPPEDLQILEQFFDQRVAAPPYRPAVVTSFTRMLNLPSQVMKDFIQIMRLDLIPELGQGNKWNVQFILRMPPSATPIVPVGTTTILSHRQKILFFIQITRVPYLPNMELKDSVTMLLPMVYDMTVNHTQLAERREQVIPQLTSAVSAHLRRFVECTVLQPGECSLFPAVRDLLMNLTLPNEQPPPGQMGNQVSS
Length1506
PositionTail
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Culicinae> Aedini> Aedes> Stegomyia.
Aromaticity0.07
Grand average of hydropathy-0.252
Instability index51.17
Isoelectric point8.53
Molecular weight168795.77
Publications
PubMed=17510324

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32002
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     318.42|      61|      66|    1042|    1102|       1
---------------------------------------------------------------------------
 1011- 1039 (28.64/ 8.42)	.....RRSQSEDD..........N...PPS...PIT.MEDPHggPASV....GST................
 1042- 1102 (122.40/63.84)	SGGAMRGPQSPRDPGL.RFAAPLT...PPSGSNPHT.PASPH..PQGI...GGSQSHPNFNMTSPPAPHMP
 1107- 1155 (79.81/38.67)	SGGLM..PSSPLNPQ.............PS...PMA.AHSPG..PTNLpymSGHTDSP.FSAHSPAASNWP
 1161- 1225 (87.57/43.26)	PRPSPRPGQSPDHKAQsRFMAVSTstePPHHNTSRVlPARSW..AGAI...PTLLTHEALDTLCRATIH.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.94|      25|      67|     823|     847|       2
---------------------------------------------------------------------------
  823-  847 (43.57/33.13)	REQIK...NDKYNLHNIVTIKSYSYTSL
  888-  915 (40.38/30.10)	RDQLQahlNHNYDLAQIVYLLHETYQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.69|      23|      67|    1343|    1366|       3
---------------------------------------------------------------------------
 1343- 1366 (36.72/26.48)	TRMLNLPSQVMKdFIQIMRLDLIP
 1395- 1417 (40.96/24.78)	TTILSHRQKILF.FIQITRVPYLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.42|      44|      76|     142|     185|       4
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  142-  185 (76.27/42.54)	LTT.GTYSRLP.SIIRERIVPPDPITTLEKR..QTLQ..RLNQVIQHRLV
  215-  264 (58.15/30.76)	LTVmGDGPNIPwRLLDIDILVEDKETGDGKAlvHTLQvnYIHQLIQGRIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.26|      49|      67|     285|     333|       7
---------------------------------------------------------------------------
  285-  318 (47.42/25.32)	...............................QLEVLYTQTLR..LMRDRLDDHIHVDEYIPGTKLTV
  319-  382 (67.87/39.21)	SYWRELTN.KDPKSELgyrlmiqtdqsdttkQLAILHLPSIG..TKEVDIADRAVRSELLSMERLLV
  385-  414 (29.97/13.46)	VYVRSLARlGDLKTEL..........................qlFLKD.......VDYSIQGT....
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.70|      23|      76|     644|     666|       8
---------------------------------------------------------------------------
  457-  481 (34.34/19.76)	PE......LQHALNNDRSKLQhlFSELRYWI
  482-  507 (21.79/ 9.74)	TQrrcektLQHLPATTQERLP..LVFPA...
  644-  666 (39.56/23.93)	PE......LAHVVAMCDEKLP..FVALAKDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.17|      31|     105|     743|     776|      10
---------------------------------------------------------------------------
  743-  776 (49.38/39.05)	LLSVSVRAQINKSIqtrMWTVE.....LVFYGTPLA.SAH
  848-  884 (47.78/29.67)	LLAYGPNKEVNVNI...YWDTEakefkMVFTGGNNAiNAH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32002 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YRRRSQSEDDNPPSPITMEDPHGGPASVGSTFLSGGAMRGPQSPRDPGLRFAAPLTPPSGSNPHTPASPHPQGIGGSQSHPNFNMTSPPAPHMPHPSPSGGLMPSSPLNPQPSPMAAHSPGPTNLPYMSGHTDSPFSAHSPAASNWPGSPGMPRPSPRPGQSPDHKAQSRFMAVSTSTEPPHHNTSRVLPARSW
1009
1202










Molecular Recognition Features






MoRF SequenceStartStop




NANANA