<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31991

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNQDSGAAASLSNGENKKRSFEGKMVNGEPKTAPGTPTVNGAPSTGPGSALAVSAPLVPTPDALAELPPEIAHITQEHYHPLSTLLLRISQETYNDLSETLQAMAQMPLAPQTNGVMTNGAGAHRNAQKNEEAIKIYTNAAAERNPDIATAIEILSTGKAPWMPSLGYIPPEPISPEQALKLLRYVNTTMSIRLNVHESLPRHLQDWRIESGRTTFVMGKELEFDVISFSEDTSEQWWLVDLRLLFSPAPTITVNSHFFERVQMQANAISKEKGLVGLFDFFNNFVLTHKISVLRSQALALVRSEWAGSLKVENVHRELVVSYWTDRPTKKNWIELGISKNNTRKGKSSWRGQSLPSLNMRWFRQGVEVKDFKLDFDWHNLSFERVIKRIIACHASDILRSTHESLNPQLVAGSSLSDSEPADCKLQVSLGTSGNAATLSLEPVTGSYILQPATHVTARAEHAFNQGREPKVMANILTEVLAQTLHELVQKHAQQLGWHNINRPALPSDSVKSAVKLAVIRYAMYTPRGWSSTWALGNVVDATGSSWWIFEIGKNGTAIEHAEQIKMDRPDGSTLAITRSTLASLERVAVQLLSARVTVRQLEKEKKQFSLRYELGQQKRKMKTSVAADMQKLMAASPQKGFKFSADGSFRILLSTPFGQDILGELRGRLRDVNRLRSFATTLQKREMRLGSSSLQRVEFRYGPSSHVAAVSFGAEKEIAIEMSHKNPHHRVHKMLTDIANSHNQQLPGIFTGDANGLDRFCTTLLVTRPLVTALQALEANDANVNARNPATHVHSLFKYRLAYENPVCTFDVRVQPKDDKVYWFIEDNMKKHTPDLRPTPERYPTHQRLETLQEKLKEFFSSKGERWFGTRNGLVAEIDGVGEALSKLNECVLSCTMEGGYKAPPPLVLPAAQPQTQQPQAQQPQMTGQQQQQQQQIANQQRLQQQARQQQAQQQGQRRPPQQNQQQNGRPQMQNGRPPQQQQPQGRPNGRPGQGQDVITID
Length1003
PositionTail
OrganismPhaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Phaeosphaeriaceae> Parastagonospora.
Aromaticity0.07
Grand average of hydropathy-0.539
Instability index51.28
Isoelectric point9.37
Molecular weight112015.64
Publications
PubMed=18024570

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31991
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     124.22|      16|      16|     958|     973|       1
---------------------------------------------------------------------------
  915-  926 (19.33/ 6.53)	.....PQTQQPQ...AQQPQ
  927-  937 (22.23/ 8.69)	MT..GQQQQQQQ.......Q
  941-  956 (27.31/12.49)	QQ.RLQQQARQQ...QAQQQ
  958-  973 (35.26/18.42)	QR.RPPQQNQQQ...NGRPQ
  975-  993 (20.10/ 7.11)	QNgRPPQQQQPQgrpNGRP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.77|      15|      15|     319|     333|       2
---------------------------------------------------------------------------
  301-  316 (19.08/ 8.32)	LVRSEWAGSLKVENvH
  319-  333 (28.59/15.75)	LVVSYWTDRPTKKN.W
  336-  350 (24.10/12.24)	LGISKNNTRKGKSS.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.15|      14|      15|     133|     146|       3
---------------------------------------------------------------------------
  133-  146 (24.89/12.93)	AIKIYTNAAAERNP
  151-  164 (24.26/12.43)	AIEILSTGKAPWMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.04|      15|      15|     555|     569|       4
---------------------------------------------------------------------------
  555-  569 (25.54/17.83)	NGT..AIEHAEQIKMDR
  571-  587 (18.50/10.88)	DGStlAITRSTLASLER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.65|      11|      15|     358|     368|       5
---------------------------------------------------------------------------
  358-  368 (21.26/11.61)	LNMRWFRQGVE
  374-  384 (21.39/11.72)	LDFDWHNLSFE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31991 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAPPPLVLPAAQPQTQQPQAQQPQMTGQQQQQQQQIANQQRLQQQARQQQAQQQGQRRPPQQNQQQNGRPQMQNGRPPQQQQPQGRPNGRPGQGQDVITID
2) LSETLQAMAQMPLAPQTNGVMTNGAGAHRNAQKNEEAIKIYTN
3) MNQDSGAAASLSNGENKKRSFEGKMVNGEPKTAPGTPTVNGAPSTGPGSALAVSAPLVPTPDALAELPPEIAHITQ
903
97
1
1003
139
76










Molecular Recognition Features






MoRF SequenceStartStop




1) KKRSFEGKMV
17
26