<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31977

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTSSASLRAGPPSPSSPAAGLLKETHSSFASSEPTPQTPTSPPLMSVSAQNYASNFASSQTSSSQATSQPANLSSPPSSAPMSAQASQQPAVGMTASFPTPASSVTGHVAGATSMDDTESTDNKPLGSDAGATSMAPTDPSLRQVEHRPTNHDRPLGGLDTDTGTSVAKAAAYDGAMDIDQDTATTSQHQSSLDSLQKEFSSPFHLCKNSYTATGPDPALDLVSLYGLGPGGEIRRKNGPSLGLAGRNKPVKNDPNKSGGLRHMTMWPEEEWQNQKVYGKDIKAADIDSTLYNLQLKAMKMEPGMVPNNDYWEDVLGHEKPSKHAGSGEGSKKPAAAPNGARIPGPPNGTPGATDAERTRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNGEGIGKKKRKKVG
Length409
PositionHead
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.05
Grand average of hydropathy-0.846
Instability index50.92
Isoelectric point5.94
Molecular weight42820.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31977
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.02|      23|      24|      14|      36|       1
---------------------------------------------------------------------------
    8-   32 (36.37/11.74)	ASLRagPPSPSSPAAGLLKETH....SSF
   33-   59 (26.83/ 7.12)	ASSEptPQTPTSP..PLMSVSAqnyaSNF
   69-   88 (33.82/10.50)	ATSQ..PANLSSPPS...SAPM....SAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     282.90|      52|      98|     115|     166|       2
---------------------------------------------------------------------------
  115-  165 (81.00/39.55)	.............ATSMD.DT.ESTDNKPLGSDA..............GATSMAPTDPS....LRQVEHRPTN..HDRPLG.GL..DTD
  166-  234 (39.86/15.65)	TgtsvakaaaydgAMDIDqDT.ATTSQHQSSLDSlqkefsspfhlcknSYTATGP.DPA....LDLV...........SLY.GL..GPG
  236-  284 (44.00/18.05)	...................EI.RRKNGPSLGL.A..............GRNKPVKNDPNksggLRHMTMWPEEewQNQKVY.GK..D..
  287-  331 (56.35/25.23)	.............AADID.STlYNLQLKAMKMEP..............G...MVPNNDY....WEDV....LG..HEKPSK.HA..GSG
  332-  389 (61.69/28.33)	E.......gskkpAAAPN.GA.R.IPGPPNGT.P..............GATDAERTRPS....RGRKRHYDDN..SFVGYGeGYadDDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31977 with Med19 domain of Kingdom Fungi
Unable to open file!