<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31975

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRAIDGFSTIYYRIYTDEQSIPSVPGDASSNAQAILRHLSRLKDLELRLRNLDCLVSSIPRRLGLWVFSATPDFENLTPLYLNNGKDEQNRIAVGSSTLKVSASGSVPAADLVRTLSSESPNTSGNQSGSQRPPNASTPTRRTDNYSSVALIYALFISAVTGALNSQLIRRNNAIPLGPRTLYSVVEKDSNNSPGVVISDASMVPCLATLQVQLTVIGKLTVSLQTISQPGLMRLRQPGDNLADVAALPPWTDLWLCPSGTIARLISTSPNTTNLSSPYPGAPPMKNDIVTTDPTQWKANVLDWLKNFGLTVEPEDDFSWVMVEVWEPFYSRLAGETWRPSDSSSTIPLKRILWPDIYCFRRKKSTISDDIKWMRQDVSDPLDFVQTWHGKQLPKPEVGSPGTPSNQQATSNPPGNHDASSLSEDVLEGLESLSRASQYPELQSASLVYPTPPDGAAGLGLNATATSDTFADDSDFGSGVLQRNGKAKFLEDTGAVPMEFGPSAGLTVGSGLYDTNEDNDLFGDMNERDFGTKGITDADFSFFDDPGFDHLGGDVPDSAQALSDMMELTEPNTQPTIVEAPPEAPVTEGPPVPEPDIPHVDHTDNPTGSHHGGSPVHDSPIRQQSPTEKNQTISPPLSPVEIKRILFPGTNGNVQPSTRKGRSQSYYNPIAFKEDISTWDQKYGASGKFGFTIQEPRALRYPSTSNGDIPTVGLPGRSRKVPMVDGVVLDVHDSSDAGQQNDLVSDSGSDSSDDGDNFLSEGDAPETVVSSLKRKRARSNSGNSLALSQAKSTNEGDKGTPAPKVDHSIFLGNFLSTSSDWSMAGYFSFQENQIFPVLARKDFQVQIAQLLVDQVTQSSLDHKLDGTCSISDLESETYSIQTFLDDNSFMSGIERLDLNGFVSLLDSDSVASPAPNGVSSRQPSQRKDALKGSLTKLPPPHLRVRRGKEYLEALPPTVLFWETFGLEPAHGPKDVSAYCIHPRIASNSADAFLDRLGSVYSSCNLGKHTRGDRCDAFDRGLGVWDISSDEVADYSSAMQSLKSLCANLGSALLKSPPSKDNLVIYIVNPFAHAAALVDICSAFWSLFQTYIAAADKQHTLQLDELVLQIVPVDFIMSTDSFVVPPQTQYLNLALEVYSRCPPKDQQTSLVNCAPPVLITEPLPKSINFRLASEKTSPLQEGKCLHVASSRSQDQRWISVAWSDNTGSLQRTMSYNIRFRNATASRTLQDVRGEIWGATKDIMERIQARWRIVLVNSDPVDQDEVDSWTKFVEQYNKANATPVELTMLNVSATPDLYLDPPPLPIPMSVFNPQTSSTPIATPNPSVLSPDQTGNASTPPSGGYSMANAPTPTDSALEAESESLLTDVTDETWAVTLSHRLNSSPHLMDYRPALASGYLLRRKGATDGDGVYTLTLNLIYTQRHSSSYETVLREILQMYRDLATLARARGTRTVQRSAMPWHIATAVRAQEALSYVM
Length1485
PositionKinase
OrganismAspergillus terreus (strain NIH 2624 / FGSC A1156)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.385
Instability index45.35
Isoelectric point4.93
Molecular weight161787.68
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     185.04|      43|      53|     462|     504|       1
---------------------------------------------------------------------------
  406-  456 (57.47/35.26)	PEVG.SPGTPS.NQQATSNppgnhdasSLSE..DVLEGLESLSRASQYPELQSAS
  462-  504 (72.17/46.63)	PPDG.AAGLGL.NATATSD........TFAD..DSDFGSGVLQRNGKAKFLEDTG
  512-  557 (55.40/33.66)	PSAGlTVGSGLyDTNEDND........LFGDmnERDFGTKGI.TDADFSFFDDPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.52|      48|      53|     717|     769|       2
---------------------------------------------------------------------------
  717-  769 (75.11/55.77)	GDIPTVGLPGRSRKVPMVD.GVVLDVhdsSDAGQQNDlvSDSGS.....DSSDDGDNFL
  772-  825 (71.41/40.34)	GDAPETVVSSLKRKRARSNsGNSLAL...SQAKSTNE..GDKGTpapkvDHSIFLGNFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.14|      16|      22|     599|     619|       3
---------------------------------------------------------------------------
  599-  614 (31.62/10.56)	GPPVPEPDIPHVDHTD
  623-  638 (28.52/16.60)	GSPVHDSPIRQQSPTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.85|      38|     290|     356|     401|       4
---------------------------------------------------------------------------
  358-  401 (66.70/41.59)	PL.....KRILWPDiycfrrKKSTISDDIKWMR.QDVSDPLDFVQ...TWHGK
  646-  692 (54.15/20.37)	PLspveiKRILFPG......TNGNVQPSTRKGRsQSYYNPIAFKEdisTWDQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     317.43|     104|    1208|      20|     206|       5
---------------------------------------------------------------------------
   70-  206 (161.78/161.41)	PRRLGLWVFSATPDF....ENL.TPLYLNNGKDEQNRIAV.GSSTLkvsasgsvpaadlvrtlsseSPNTSGN....QSGSQRPPNASTPTRR.............TDNYSSVALiyalfisavTGALNS..QLIRRNNAIPLGprtlYSVVEKDSNNSPGV
 1291- 1419 (155.66/59.41)	PVELTMLNVSATPDLyldpPPLpIPMSVFNPQTSSTPIATpNPSVL....................SPDQTGNastpPSGGYSMANAPTPTDSaleaeseslltdvTDETWAVTL.........SHRLNSspHLMDYRPALASG....YLLRRKGATDGDGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.47|      23|     522|     306|     328|       7
---------------------------------------------------------------------------
  304-  326 (42.75/23.74)	PTQW.KANVLD..WLKNFGLTVEPED
  327-  352 (35.72/18.69)	DFSWvMVEVWEpfYSRLAGETWRPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.44|      14|      15|    1169|    1182|       9
---------------------------------------------------------------------------
 1169- 1182 (24.27/15.76)	TEPLPKSINFRLAS
 1185- 1198 (25.17/16.65)	TSPLQEGKCLHVAS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31975 with Med13 domain of Kingdom Fungi
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