<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31962

Description Isoform 3 of Prostate tumor-overexpressed gene 1 protein
SequenceMVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPMEGARVFGALGPIGPSSPGLTLGGLAVSEHRLSNKLLAWSGVLEWQEKRRPYSDSTAKLKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTNRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRKQAVGPGGVNSGPVQIVNNKFLAWSGVMEWQEPRPEPNSRSKRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFTKDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQQVLQRNLEQEQQQRGMGG
Length227
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.08
Grand average of hydropathy-0.345
Instability index50.04
Isoelectric point10.54
Molecular weight46868.00
Publications
PubMed=11313889
PubMed=14657022
PubMed=15498874
PubMed=12975309
PubMed=15489334
PubMed=12598323
PubMed=15713644
PubMed=15778465
PubMed=16639697
PubMed=17641689

Function

Annotated function May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. 
ECO:0000269	PubMed:12598323
ECO:0000269	PubMed:15713644
ECO:0000269	PubMed:17641689
GO - Cellular Component
nucleoplasm	GO:0005654	IDA:HPA
perinuclear region of cytoplasm	GO:0048471	IEA:UniProtKB-SubCell
plasma membrane	GO:0005886	IEA:UniProtKB-SubCell
transcription regulator complex	GO:0005667	IBA:GO_Central
GO - Biological Function
GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31962
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     600.90|     154|     159|      79|     237|       1
---------------------------------------------------------------------------
   79-  237 (299.50/227.06)	GGLAVSEHRL.SNKLLAWSGVLEWQEKR.RPYSDStaklKRTLPCQAYVNQGENLETDQWPQKLIMQLIPQQLLTTLGPLFRNSQLAQFHFTnRDCDSLKGLCRIMGNGFAGCMLFPHISPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVSAIRQVITTRK
  243-  398 (301.40/215.30)	GGVNSGPVQIvNNKFLAWSGVMEWQEPRpEPNSRS....KRWLPSHVYVNQGEILRTEQWPRKLYMQLIPQQLLTTLVPLFRNSRLVQFHFT.KDLETLKSLCRIMDNGFAGCVHFSYKASCEIRVLMLLYSSEKKIFIGLIPHDQGNFVNGIRRVIANQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.97|      25|      46|       2|      26|       2
---------------------------------------------------------------------------
    2-   26 (52.98/21.70)	VRPRRAPYRSGAG..GPLGGRGRPPRP
   29-   48 (34.64/12.05)	VRAVRS..RSWPA..SPRG..PQPPR.
   50-   74 (34.36/11.90)	.RARSAPPMEGARvfGALGPIG.PSSP
---------------------------------------------------------------------------











Associated diseases
Disease
Charcot-Marie-Tooth (CMT) disease	PMID:19290556



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31962 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MVRPRRAPYRSGAGGPLGGRGRPPRPLVVRAVRSRSWPASPRGPQPPRIRARSAPPM
1
57










Molecular Recognition Features






MoRF SequenceStartStop




1) MVRPRRAPYRSGAGGPL
1
17