<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31956

Description CROL GAMMA
SequenceMQHVSAASSVPSVVTPVVTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKGHLVSHMRSHSGEKPHACTLCSKAFVERGNLKRHMKMNHPDAMMPPPPVHPHPQIPAGVLTQVKQEVKPIIIPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
Length756
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.04
Grand average of hydropathy-0.762
Instability index51.85
Isoelectric point9.36
Molecular weight82882.17
Publications
PubMed=9521911
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867
PubMed=26109357
PubMed=26109356
PubMed=25589440

Function

Annotated function 
GO - Cellular Component
heterochromatin	GO:0000792	IDA:FlyBase
nucleus	GO:0005634	IDA:FlyBase

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central

GO - Biological Process
cell adhesion	GO:0007155	IMFlyBase
heterochromatin organization involved in chromatin silencing	GO:0070868	IMFlyBase
imaginal disc-derived wing morphogenesis	GO:0007476	IMFlyBase
negative regulation of transcription, DNA-templated	GO:0045892	IMFlyBase
negative regulation of Wnt signaling pathway	GO:0030178	IGI:FlyBase
positive regulation of mitotic cell cycle	GO:0045931	IMFlyBase
regulation of chromatin silencing	GO:0031935	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IMFlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            12|     640.75|      27|      27|     330|     356|       1
---------------------------------------------------------------------------
  180-  207 (51.16/24.59)	QTPHQCDVCgKKYTRKEHLANHM.RSHT.N
  208-  235 (52.05/25.14)	ETPFRCEICgKSFSRKEHFTNHI.LWHT.G
  236-  263 (59.81/29.88)	ETPHRCDFCsKTFTRKEHLLNHV.RQHT.G
  264-  291 (61.02/30.62)	ESPHRCSYCmKTFTRKEHLVNHI.RQHT.G
  292-  319 (56.74/28.00)	ETPFKCTYCtKAFTRKDHMVNHV.RQHT.G
  320-  347 (61.82/31.11)	ESPHKCTYCtKTFTRKEHLTNHV.RQHT.G
  348-  375 (59.68/29.80)	DSPHRCSYCkKTFTRKEHLTNHV.RLHT.G
  376-  403 (58.29/28.95)	DSPHKCEYCqKTFTRKEHLNNHM.RQHS.S
  404-  432 (53.50/26.03)	DNPHCCNVCnKPFTRKEHLINHMsRCHT.G
  433-  461 (41.43/18.66)	DRPFTCETCgKSFPLKGNLLFHQ.RSHTkG
  465-  492 (49.02/23.29)	ERPFACEKCpKNFICKGHLVSHM.RSHS.G
  493-  520 (36.24/15.49)	EKPHACTLCsKAFVERGNLKRHM.KMNH.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.27|      21|      21|     623|     643|       2
---------------------------------------------------------------------------
  598-  618 (37.06/10.66)	AAQQQSQK...QQAAAAAAAQQQA
  623-  643 (42.22/13.10)	AAQQQAAQ...QQAAAAHQQHQQQ
  645-  663 (35.53/ 9.94)	AAQHQ..Q...QAAVAAHQQQQQQ
  665-  688 (31.46/ 8.02)	QQQQQLLQlsiQQAAHHHQQEQHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.48|      16|      22|      98|     113|       3
---------------------------------------------------------------------------
   98-  113 (27.31/15.40)	VTSHAASAAAAAAAAS
  122-  137 (27.17/15.28)	VMASANAAAAAAAAAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.06|      14|      19|     689|     702|       4
---------------------------------------------------------------------------
  689-  702 (28.56/ 9.09)	QQQQQQHQQQQQQQ
  705-  718 (30.50/10.18)	QQQQQGHPQAPPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.43|      10|     434|      88|      97|       5
---------------------------------------------------------------------------
   27-   36 (21.47/ 8.18)	LGGPPPLPKS
   88-   97 (24.96/10.70)	LPPPPPLPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.95|      29|      30|     534|     562|       6
---------------------------------------------------------------------------
  534-  562 (50.50/23.65)	QIPAGVLTQVKQ.EVKPIIIPHHSATTTMH
  566-  595 (42.45/18.81)	QITAGAAGGAGAvQLTPGLVPLVTSTLISH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.94|      13|      25|     139|     155|       7
---------------------------------------------------------------------------
  139-  155 (15.08/17.63)	GGGlppATSGnGGQQVT
  165-  177 (23.86/10.59)	SGG...STTS.GGTTTT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31956 with Med12 domain of Kingdom Metazoa
Unable to open file!