<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31955

Description CROL BETA
SequenceMQHVSAASSVPSVVTPVVTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEMYKVNIEDISQLFTYHEVFGKIHGDVVNHQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAAAASTNNAAVAAVMASANAAAAAAAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAPDGTPIATGTHVCDICGKMFQFRYQLIVHRRYHSERKPFMCQVCGQGFTTSQDLTRHGKIHIGGPMFTCIVCFNVFANNTSLERHMKRHSTDKPFACTICQKTFARKEHLDNHFRSHTGETPFRCQYCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHYVNHYMWHTGQTPHQCDVCGKKYTRKEHLANHMRSHTNETPFRCEICGKSFSRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCSYCMKTFTRKEHLVNHIRQHTGETPFKCTYCTKAFTRKDHMVNHVRQHTGESPHKCTYCTKTFTRKEHLTNHVRQHTGDSPHRCSYCKKTFTRKEHLTNHVRLHTGDSPHKCEYCQKTFTRKEHLNNHMRQHSSDNPHCCNVCNKPFTRKEHLINHMSRCHTGDRPFTCETCGKSFPLKGNLLFHQRSHTKGQEMERPFACEKCPKNFICKVPHHSATTTMHTIQQITAGAAGGAGAVQLTPGLVPLVTSTLISHNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQQQLQQQQQLLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
Length891
PositionKinase
OrganismDrosophila melanogaster (Fruit fly)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Sophophora.
Aromaticity0.05
Grand average of hydropathy-0.756
Instability index47.93
Isoelectric point9.30
Molecular weight98464.53
Publications
PubMed=9521911
PubMed=10731132
PubMed=12537568
PubMed=12537572
PubMed=12537573
PubMed=12537574
PubMed=16110336
PubMed=17569856
PubMed=17569867
PubMed=26109357
PubMed=26109356
PubMed=25589440

Function

Annotated function 
GO - Cellular Component
heterochromatin	GO:0000792	IDA:FlyBase
nucleus	GO:0005634	IDA:FlyBase

GO - Biological Function
DNA-binding transcription factor activity, RNA polymerase II-specific	GO:0000981	IBA:GO_Central
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IBA:GO_Central

GO - Biological Process
cell adhesion	GO:0007155	IMFlyBase
heterochromatin organization involved in chromatin silencing	GO:0070868	IMFlyBase
imaginal disc-derived wing morphogenesis	GO:0007476	IMFlyBase
negative regulation of transcription, DNA-templated	GO:0045892	IMFlyBase
negative regulation of Wnt signaling pathway	GO:0030178	IGI:FlyBase
positive regulation of mitotic cell cycle	GO:0045931	IMFlyBase
regulation of chromatin silencing	GO:0031935	IMFlyBase
regulation of transcription by RNA polymerase II	GO:0006357	IMFlyBase









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31955
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            17|     754.15|      25|      25|     538|     562|       1
---------------------------------------------------------------------------
  221-  245 (20.69/ 7.30)	...HVCDICgkmFQFR.YQLIVHR.RYHS.E
  246-  273 (31.90/15.68)	RKPFMCQVCgqgFTTS.QDLTRHG.KIHI.G
  274-  301 (25.69/11.04)	GPMFTCIVCfnvFANN.TSLERHM.KRHS.T
  302-  329 (47.86/27.62)	DKPFACTICqktFARK.EHLDNHF.RSHT.G
  330-  357 (53.54/31.86)	ETPFRCQYCaktFTRK.EHMVNHV.RKHT.G
  358-  385 (53.04/31.49)	ETPHRCDICkksFTRK.EHYVNHY.MWHT.G
  386-  413 (46.60/26.68)	QTPHQCDVCgkkYTRK.EHLANHM.RSHT.N
  414-  441 (48.94/28.43)	ETPFRCEICgksFSRK.EHFTNHI.LWHT.G
  442-  469 (54.48/32.57)	ETPHRCDFCsktFTRK.EHLLNHV.RQHT.G
  470-  497 (54.92/32.90)	ESPHRCSYCmktFTRK.EHLVNHI.RQHT.G
  498-  525 (52.69/31.23)	ETPFKCTYCtkaFTRK.DHMVNHV.RQHT.G
  526-  553 (55.56/33.38)	ESPHKCTYCtktFTRK.EHLTNHV.RQHT.G
  554-  581 (53.68/31.97)	DSPHRCSYCkktFTRK.EHLTNHV.RLHT.G
  582-  609 (51.05/30.01)	DSPHKCEYCqktFTRK.EHLNNHM.RQHS.S
  610-  638 (48.08/27.78)	DNPHCCNVCnkpFTRK.EHLINHMsRCHT.G
  639-  667 (33.53/16.90)	DRPFTCETCgksFPLK.GNLLFHQ.RSHTkG
  671-  698 (21.91/ 8.21)	ERPFACEKCpknFICKvPHHSATT.TMHT..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     139.98|      21|      21|     758|     778|       2
---------------------------------------------------------------------------
  751-  775 (36.86/10.71)	QQAaaaaAAQQQAAQ...QQAAAAHQ..QH
  776-  795 (34.05/ 9.45)	QQQ...vAAQHQ..Q...QAAVAAHQ..QQ
  796-  822 (29.63/ 7.46)	QQQ...lQQQQQLLQlsiQQAAHHHQqeQH
  826-  842 (39.43/11.86)	QQQ....QHQQQ.QQ...QQ...HHQ..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.85|      33|     620|      81|     136|       4
---------------------------------------------------------------------------
   81-  136 (45.93/27.54)	AAAHGG....QLPppPPLPPqvtshaasaaaaaaaastnnaAVAAVMASANAA.........AAAAAAA
  704-  749 (46.92/17.75)	AGAAGGagavQLT..PGLVP.....................LVTSTLISHNAAaqqqsqkqqAAAAAAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      62.42|      14|      27|     137|     152|       5
---------------------------------------------------------------------------
  137-  152 (24.64/18.18)	SAGG..GLPPatSGN....GGQ
  164-  174 (19.51/ 7.93)	SSGG..S.....TTS....GGT
  186-  205 (18.27/ 6.97)	MEGGihGVDG..SGNggngGGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31955 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAASAGGGLPPATSGNGGQQVTVTTTSSSTSSGGSTTSGGTTTTAGELLMPKMEGGIHGVDGSGNGGNGGGQNVALAP
2) HNAAAQQQSQKQQAAAAAAAQQQAAAAAAAQQQAAQQQAAAAHQQHQQQVAAQHQQQAAVAAHQQQQ
3) HQLAAAHGGQLPPPPPLPPQVTSHAASAAAAAA
4) LLQLSIQQAAHHHQQEQHRQQQQQQHQQQQQQQHHQQQQQGHPQAPPPQQQQQPPPIALISDPSALARAAIQLQHLPANVEQHPVVY
5) VTTGGTTITLGGPPPLPKSEHKEDGKPPHGIEM
133
730
78
805
18
211
796
110
891
50










Molecular Recognition Features






MoRF SequenceStartStop




NANANA