<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31951

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceMPFLISCLGGSYTPQGGPPSYPRTQESMIVNSVGSPASVAPSPLQGPHSQPASVPPADATMPTLSPNPPISDQSPSLARDKSHTPPDSVRLPPKKYEVALGEEEHTLDMLYDYSTQEAWLNLPVKRFKPDSKDSRFGKRVDLYTLYHHNGISQCSDINNMNNTIKMEIKQEPGTMSEMDSSRSMQQSHGIKRPGDPYEFEEDGSNPNCKIDGFIRTPPIKEEPKDKKDILFTSEGLQPSYKDLEQIFDNSDYTSSDEATPPGSAGPTTNHHLLHHDDTIPTKRLSGHGQTNLGGCPNVGMPPELSKMFPTPPSLEHNPIASPCGQLDLGQQDYPDITIVRVKQENIYPMMGSPQEENIDDWSYVFKPSLCCKMVGSSKYAPLNNLPSQVQPLSVPGNCTYKPSWVQHMENNKQHQQNSNNNNTTSSNNNNNTSNNLNSRNRTPTPSMANNIHPNAGIFPPSPLHPPGFRPPPPPYELPSPANSTTSSYLNKNINSVEPVPTPQPNHRTPEASSLVLNILLTDTAFNIFRDHNFDSCTLCVCNASPKVVGNIRGADSGIYLLNSHSDKLHASAQPTSPYPGLGQPPPYGSMMSPQHHGASEEDQIRCSCGFSAVVNRRLAYGSGLFYEDEMEITGIAEDPGERKKSSLASLLTSLNCLKSDATIDRDQLESIPHNVVNLICDQLVFIPSTANALCRAARYVKHSKGAVYSNPLHYLEYSDSNEVTSIALEQSKNLLENLGMCKMENDKHSKLNNSFGVHKWPYLRAPGPQCNQDIVRVMKSLQPLLQDAIQKKCQTRLWEAPSAVKGPLTWRQFHRLAGRGTDDRCEPQPIPSVIVGHDKDWLCLSPYALQQWESLMLEPYSYSRDVAYVVVAPDNEAILPRVKTFFKELSASYEICKLGRHSPITKVLRDGILRVGKTAKMKIGNEPVEEWFNLLGDGEASEMLKLYAQVCKHHLAPHLQQVPMDKTLLDPPSDNISERPAPSPMPPPSTPDPNNSSQSFSSQDKAPSTPKSDQDGDGLKDIPSFGNSISDMLHDDDEREAPSVIVYLVEPFSLSSTHPDMQRLAVLALLRCFQSVLAAVPENIRSNIGVQIISLESIVELNKSRERMRHSDHMRALALNIFSQCRRLLMHSNNVKSLTGFGTAATADLFLKSKDEKNRAPYRLFTPPYVLAPMREKVEASEAFGKGSQDQSSVLYISYCLSEDQSWLLAVGTDERGEIFENVTINIDIPNRSRRKKASARRVALEKLMTFILGIMSQSVRPWRLVVSRLGRIGHGELKGWSWLLSKPNLVKASRHLKEICNQCSMLYPSAVPCIISACLVSIEPDSCLRLMPDQFTPDERFSQASVNSQLSTPQDVSCTHILVFPTSATTQSSQTAFQEQHISGDLGDDELFKAFGDDMAVEVDNDISEIFNGWDQIGYQSPNGSPRREDAGVGSPSGGVAGGMEGNLGAPGGAPKGQESNEEVGVVLQQPLALGYLVSTAPTGRMPRWFWTSCPHLEGVCPVFLKNALHLHSPNIQQNSDDLFQQAAQVSSHPLDSQYTTDVLRYVLEGYNALSWLSFDSNTKDRLSCLPVHMQVLVQLYHTAAALL
Length1589
PositionMiddle
OrganismDendroctonus ponderosae (Mountain pine beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Curculionidae> Scolytinae> Dendroctonus.
Aromaticity0.07
Grand average of hydropathy-0.503
Instability index57.83
Isoelectric point5.85
Molecular weight175436.75
Publications
PubMed=23537049

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31951
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.55|      59|     185|    1148|    1238|       1
---------------------------------------------------------------------------
 1034- 1092 (101.44/50.37)	HDDDER......EAPSVIVYLVEPFSLSST..HPDMQRLAVLALLRCF...QSVLAAVPENIRSNI..GVQI
 1154- 1225 (80.11/101.96)	KDEKNRapyrlfTPPYVLAPMREKVEASEAfgKGSQDQSSVLYISYCLsedQSWLLAVGTDERGEIfeNVTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     824.95|     268|     334|     120|     451|       2
---------------------------------------------------------------------------
  120-  451 (409.91/277.83)	LNLPvkRFKPDSKDsrfgkrvdlYTLYHHNGISQCSDINNMNNTIKMEIKQEPGTMSEMDSSRSM.....QQSHGIKRPGDPYEFEEDGSNPNCKIDGFIR.TPPIKEEPKDKKDILFTSEglQPSykdleqifdnSDYTSSDEATPPGSAgPTTNHHLLHHDDTIptkRLS.GHGQ.TNLGGCPNVGM....PPELSKMFPTPPSLEHNPIASPCGQLDLGQQdypDITIVRVKQENIypmmgsPQE.ENIDDWSYVFKPS....LC..CKMVGSSKYAPLNNlpsqvqPLSVP.......................GNCtykpswvqHMENNKQhqqnsnnnnttsSNNNNntSNNLNSRN..RTPTPSMANNI
  463-  774 (415.04/188.54)	LHPP..GFRPPPPP.........YELPSPANSTTSSYLNKNINSVEPVPTPQPNHRTPEASSLVLnilltDTAFNIFRDHNFDSCTLCVCNASPKVVGNIRgADSGIYLLNSHSDKLHASA..QPT..........SPYPGLGQPPPYGSM.MSPQHHGASEEDQI...RCScGFSAvVNRRLAYGSGLfyedEMEITGIAEDPGERKKSSLASLLTSLNCLKS...DATIDRDQLESI......PHNvVNLICDQLVFIPStanaLCraARYVKHSKGAVYSN......PLHYLeysdsnevtsialeqsknllenlGMC........KMENDKH............SKLNN..SFGVHKWPylRAPGPQCNQDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.15|      16|      16|     983|     998|       3
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   61-   73 (21.37/ 6.59)	..MPTLS.PNPPISDQ
  983-  998 (33.27/15.19)	SPMPPPSTPDPNNSSQ
 1002- 1014 (24.51/ 8.86)	SQDKAPSTP...KSDQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.89|      20|      22|    1288|    1309|       4
---------------------------------------------------------------------------
 1288- 1309 (32.64/32.46)	PNLVKASrhLKEIC.NQCSMLYP
 1313- 1333 (33.25/23.98)	PCIISAC..LVSIEpDSCLRLMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.87|      46|    1432|       9|      55|       8
---------------------------------------------------------------------------
    9-   55 (83.34/49.60)	GGSYTPQGGPPSYPRTQES.....MIVN...SVGSPASVAPSPlQGPHSQPASVP
 1443- 1496 (77.52/41.98)	GGMEGNLGAPGGAPKGQESneevgVVLQqplALGYLVSTAPTG.RMPRWFWTSCP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31951 with Med13 domain of Kingdom Metazoa
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