<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31947

Description Mediator of RNA polymerase II transcription subunit 7 (Fragment)
SequenceMSSDAVQVSSLPLPPMQYVSQYTDEMIRRGRAPKPPPPIQDTYHMFGNTFNTEESIIRPLESQGIKRLYPQHFDRRRELKKLNLSLLANFLDLLDLLVNCPDSPKRTEKVDDLSLLFIHIHHLLNEFRPHQARETLRVMMELQKRQRIETTNRFQKHLDKVKEILQQAVRDLPEPMDLDSKIMADVDLITKHDKMDDSNSNCDPCDIRDRIMCSIVDNM
Length219
PositionMiddle
OrganismDendroctonus ponderosae (Mountain pine beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Curculionidae> Scolytinae> Dendroctonus.
Aromaticity0.05
Grand average of hydropathy-0.629
Instability index54.02
Isoelectric point6.24
Molecular weight25689.31
Publications
PubMed=23537049

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31947
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.43|      22|      26|      74|      97|       1
---------------------------------------------------------------------------
   74-   97 (30.96/25.35)	DRRRELKKL.NLSLLanFLDLLDLL
  102-  124 (34.48/21.57)	DSPKRTEKVdDLSLL..FIHIHHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.85|      13|      26|     174|     186|       2
---------------------------------------------------------------------------
  174-  186 (22.92/11.15)	EPMDLDSKIMADV
  203-  215 (25.93/13.35)	DPCDIRDRIMCSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.69|      12|      26|     125|     136|       4
---------------------------------------------------------------------------
  125-  136 (21.87/13.53)	NEFRPH..QARETL
  152-  165 (15.82/ 8.21)	NRFQKHldKVKEIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31947 with Med7 domain of Kingdom Metazoa
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