<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31939

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMASGKSMPFSSLHPNPTGGRKPRNLGGFIARVQAERGFRNVTENSLKQEVSDRKNGFTQVPEEPTCTADGDDEADPTDAVAARVEVLRNIDIAHNAALMTLDFVSLLLSKESPAQAGVTLSQQLREWTGIGTLGIAKREDNDEQKQRDADRAKDNRDISLGWALIDIHKTKDSADKAASHLSKEIEREERYWGEVLAVHQAGWSMCRLPAERHTLGVKLGFAEGIHSPLDPVTALSSLITVASPEFRNSSLAPLRRGEDGAALLQPGRVSVGCQRLGVTVSRSGEPTGRLSTGASVLGTALLQDRVLEARNTLFAQELWHELHREAHSLASYGVRASNSVITISPATRLSLNFELETLEDSANTVAEHPDNKIAEAIHLTLHIFLSHAHRLNELQRLRPAPPHQRRHQAQNQYHLLRPIVAKILHDRSIEKVTRLAGDLTLVLRRAGIEVASFSLSTPSFPTSELKNNSGGASNRPSASQALANMFTTVPADFQVEIILTPASRVLVRGRTFLAPLTTTQFQIQLLPSVASSSGPETIPCPLQVSYPPSRDSYPDLAAVQVYLTTAATHAITDYAESLISRESAMGSQGPRAEWMKSLRGTAIRDVETETREIRFDVVENAKSRLTLQVGAAWRVEDQSRINRWSWSADVEQVSSISTVSIGAIVAAVVECKEI
Length674
PositionHead
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.05
Grand average of hydropathy-0.310
Instability index45.02
Isoelectric point6.49
Molecular weight73657.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31939
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.81|      13|      18|     265|     277|       1
---------------------------------------------------------------------------
  265-  277 (26.27/15.90)	QP.GRVSVGCQRLG
  285-  298 (19.54/10.11)	EPtGRLSTGASVLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.36|      16|      24|     511|     531|       2
---------------------------------------------------------------------------
  511-  531 (21.01/23.05)	TFLAPLtttqfQIQLLPSVAS
  537-  552 (31.34/18.90)	TIPCPL.....QVSYPPSRDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.96|      18|      28|     593|     611|       4
---------------------------------------------------------------------------
  593-  611 (29.25/20.88)	EWMKS...LR.GTAIRdVETETR
  619-  640 (23.71/11.76)	ENAKSrltLQvGAAWR.VEDQSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.51|      20|      37|     378|     397|       5
---------------------------------------------------------------------------
  378-  397 (34.33/26.31)	HLTLHIF..LSHAHRLNELQRL
  414-  435 (28.18/20.16)	HLLRPIVakILHDRSIEKVTRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.23|      42|     135|     178|     223|       6
---------------------------------------------------------------------------
  178-  223 (68.56/49.02)	ASHLSKEIEREerywGEVLAVH..QAGWSMCRL.PAERHTLGVKLGFAE
  315-  359 (62.67/34.92)	AQELWHELHRE....AHSLASYgvRASNSVITIsPATRLSLNFELETLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31939 with Med17 domain of Kingdom Fungi
Unable to open file!