<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31938

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDTVINARFERVEKALTSLIESVSKYNPHARQALDLHEADNDLARGLVEVQTHQNNHLHLQKLRATTASLDAQIRETLSSLATTRKDITTTQITLYPDGPHYPVKYDELLNYARRISKTTLPPAAITNGVPTAASTPGPDPNTSMTAATTPGANGMQSQPVSAAPTPGQTQTPDPSSAFNGASQDLAATQQTTTTTSLPDGLRNHLDPHFNASFIPWPNEFQIRSGAMAVYQDLHDKGIDPRGYDPQQIAEAKRKEEEERKAREEQERLEQERKNREYTEKMERIRREQQEAYRRDSMAVGAGASSAGKSKQFQFTSIMDDDDDDE
Length326
PositionMiddle
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.05
Grand average of hydropathy-0.915
Instability index41.14
Isoelectric point5.38
Molecular weight36230.43
Publications
PubMed=23252678
PubMed=30893003

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31938
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.25|      21|      23|     154|     174|       1
---------------------------------------------------------------------------
  128-  140 (28.73/11.96)	NGV...P.TAASTPG......PD
  154-  174 (43.30/21.10)	NGMQSQPVSAAPTPGQTQT..PD
  180-  200 (29.22/12.27)	NG.ASQDL.AATQQTTTTTslPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.29|      12|      23|     256|     267|       2
---------------------------------------------------------------------------
  256-  267 (20.58/13.28)	EEEERKAREEQE
  280-  291 (21.72/14.38)	EKMERIRREQQE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31938 with Med4 domain of Kingdom Fungi
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