<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31937

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGQNGTHSNHDRNLKINGVNGAAMDSQSSLNKGKAPAEGPGAGSLPNGVPGSSATDILGRQQSQMTKGLTLQQKPRMNDLPEEIVHITQGYIPLSTIVSRLAQQTHEHLQKTIMEMAAIKIQPPVNGNNTHGSDAPDDMSEPNKRKKMLMLKFAQDAHSKWVKALVITDWGRNAGSVSKLIDIKAHIDSKRVLYDHAQALLIDLKRSLISARLPNPDLKTALQVLTTGEATWVPEPGYIPPPPLTPEEQLKWIDDLNTMLSLRLNLDDYDKIPHQFKDYSIQSGRVTFKVKGEFEVDLTIADEDFTKQFWFIDFRFTFTPSSDKVPDALVSFLEGQINEILGRDGLEGCYRFLHEFVLTHKINELKRQAIALSRDTWTGTLMVEPLNRALAIQYWTSRYGPNGPKSWVMIAVDSAKKTNGQIDDRHSSHLVARWYRDNKEVKDVLLPFDVDDLCAEDLLKTAVARHVEHILSSIHSKLLSYPRFSTRESSMTLSISRKEPVESSLSMQLGPREHATLVIEPVTGLAAIKPHTKYTLSGENRLNYGGKDPAEDGVICLENIRWGYVIEELNRRGRSVGWNTCKGPISGEDIKQLIRTREAFQTIFLQCQSLGQNWFVMVSLSLAGDEWWLIDIDRDTPPRPMRFNTRLQISGQPHIDDKFWNNLTILVTGIISHVTDLQDFHGRKVQYLKKRAANTSLPQEVRVPSLLIKLSQVLRSTGDSGRSSTDNDSGRQKESPSSWAQDQIEIKFMGLQVRPAAQVSDANNAQAIELLENVELNTVVDAIMRVKDKSKFTLLKGRIDRDVSFSPRRGEFIFRVRQLIGKPILDTLMGHVKSIDRLVGFLEAMGKARGSVTCERMSLREVVFTYGDCSLPSDANVAPKSRRWRATLDLSRSNIRISLERGNPHIRVLDLLTTLVNATDGLKALVIFMPILLPVLKTVESIENKWEPLETTNQGRVQIFARAVDWVALRYTLNGAGGQSRILVLNIRTTVRRYETWWIVSRARIAGSSPPYDEFDKVLRSIWETSGAGWKGLMTAAAALPGPSTMELLTKLDDAIRTFAVTGGNGGPSSTDGAPTQQSQIFSSSQSFGTQMSSISQGSNRTSGSKQAPLVLD
Length1116
PositionTail
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.07
Grand average of hydropathy-0.365
Instability index41.21
Isoelectric point8.90
Molecular weight124523.49
Publications
PubMed=23252678
PubMed=30893003

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31937
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     315.34|      95|     109|     823|     930|       1
---------------------------------------------------------------------------
  831-  923 (137.32/94.26)	..............LMGHVKSIDRLVGFL.EAMGKARGSV...TCERMS.LREVVFTY...GDCSLPSDANVAPKSRRWRATLDLSRSNIRISlerGNPHIRVLDLLTTLVNATD
  924- 1030 (142.25/84.53)	GLKALvifmpillpVLKTVESIENKWEPL.ETTNQGRVQIfarAVDWVA.LRYTLNGA...GGQSRILVLNIRTTVRRYETWWIVSRARIAGS...SPPYDEFDKVLRSIWETSG
 1032- 1078 (35.77/14.34)	GWKGL........................mTAAAALPGPS...TMELLTkLDDAIRTFavtGGNGGPSSTDGAP.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.65|      19|     109|      19|      37|       2
---------------------------------------------------------------------------
   19-   37 (35.38/21.68)	INGVN..GA.AMDSQSSLNKGK
  128-  149 (27.27/14.94)	VNGNNthGSdAPDDMSEPNKRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.05|      23|     142|     383|     407|       3
---------------------------------------------------------------------------
  383-  403 (33.69/19.16)	......TL...............MVEPLNRALAIQYWT.........SRYG
  513-  548 (26.82/10.21)	GPrehaTL...............VIEPVTGLAAIKPHTkytlsgenrLNYG
  551-  586 (25.54/15.52)	DP......aedgviclenirwgyVIEELNRRGRSVGWN.........TCKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.41|      15|     166|     635|     649|      14
---------------------------------------------------------------------------
  635-  649 (31.16/20.52)	IDRDTP..PRPMRFNTR
  802-  818 (24.25/14.20)	IDRDVSfsPRRGEFIFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31937 with Med14 domain of Kingdom Fungi
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