<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31934

Description Mediator of RNA polymerase II transcription subunit 18
SequenceMYELFITTLVDDEEIQAACSVLSGFCAMPAWQSLHRVLYFKGPAKPGGISKQNSIVKTPRKDIQMLWKDLHQQLSRQSYILQARYEVYKDRDFGQNASEADLNARSGILRWTDFPEPPQPRSVVTQRKKTEIWDQRNLPSVMRDNNYQFKTEAIEETYQFFKDEIEFCLSRHYMIPPNGEGTPLTQLPPWESFNPGDPGRRWMFLIKVHVHQDNKPDEVIKAHAQLADVRRDLEGVFDFKMFDRRIHDTRVAVEMRNAPAPLPQVMTVTDQR
Length272
PositionHead
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.10
Grand average of hydropathy-0.658
Instability index58.12
Isoelectric point6.67
Molecular weight31798.81
Publications
PubMed=23252678
PubMed=30893003

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31934
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.33|      15|      20|      68|      87|       1
---------------------------------------------------------------------------
   68-   84 (20.51/28.76)	KDLHQQLSRQSyiLQAR
   91-  105 (24.82/13.45)	RDFGQNASEAD..LNAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.14|      21|      88|     124|     150|       2
---------------------------------------------------------------------------
  124-  144 (37.28/15.66)	VTQRKKTE..IWDQR.NLPSVMRD
  210-  232 (28.95/ 9.81)	VHQDNKPDevIKAHA.QLADVRRD
  247-  266 (21.91/12.71)	HDTRVAVE..MRNAPaPLPQVM..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31934 with Med18 domain of Kingdom Fungi
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