<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31933

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLINNISSIVFRVYEPCQEQAHFFSSVAADIEIELRDRGYIVYYDANKRVIWYFHISRKDAAVTNPVGLLDSTIEAAGTTLLMVEDGSFEPMGLFKGRAPGQQLINTPTSSSSSNSAVDLSLRNAQSATPGPPSSSEADIDSKSGADGKGTGFVSPKDAYDHFITAVLATISAAFCNRSSAIPLNYRSVLLPSKVARDSQAEGPLDTEAAVVGTFRIYLTTTGALILSLSLSCCEGLLSVNEPASPEQMVLGSQILAAPFGVLANYQGFMGGGSSYPEIGLGQTPDAQLWRSSDARSSQWRDTCVKILQSRGLSPTLLHSCSWIALQMLRRKPGDLKADGKATPLNSTFATISWPAILCFRKKSVVSARNHSLADPPLLAQEQISDFLTEARTWFQNGTDRDEKIAKRRKEREIAASKEASAATSAPAQQPNGHSPLGLRRASNAAASGAMYPTPPDGVQNPLGITPSMDGTTSSPGAPNATLAVADIDTTMMDHSAPDITMPNTGPHGEAYGEWVSAADNKRERAESFLGGENDNLFGDMGADLFVDAAVTDADFSFFDEEPGDDLDLSGLPDLGMPDAPPMPSALPPVMPETAHFIAPPLEQPKTEPSPPVFTKPELKHARSTLMEEGRQRSNMEKMGSTKRETSPFDPDTVYKRVRASLGDIRSTPSANPARKGSIFDSVDFDPVLPLVNKKYEQGGRFDCNPFSQGASTEASAHVVPQVPPTTDYLRRHGKNRRPLTANALIRTITGGLENAGFNSSPGKVEELASDADDISLISDQDSNSTTDEPASPFKSSIRRMNFEDDVVSHVTTVRDIESVEDGDPTLALDLPKLAKHEASEAPVTKYFEDSEPLPIQLPLPDEDLITVAQIVTEQAVTGTLKLRDGHINTLNTAIIPETRRQLSSLGRTALRTLREAVPSCLGAFRTCSLKSVIDVVDVPLLGQPNRLHPKPVPTRDSKAEPPKLPDLFQIPPPHLELRRAESRLSILPSSVQFWESLGLGPAQGPKDVSVVCVFPSWDGMADVAAAFLDRMRNVYELLKLGSFERLPTSSKVTDGLLPFEAEKVANSPGFVGSQITSGLSDRMEDLNQGLLSASATEKNFVVYFVYPPDRPGSVVEECIAFQQLFEIYKRSLAEKKQTPVNELVLQLVPLDFLISTAGIVEPTPSDAIKLALETYDRCRLFGGPMPSPAIMLEPPLPRGIDFKTNATPSPSVLHENSCMHIAYSQSIDERWITAAWTDNRGFQQMSASYNLGRKGKPLSTGVQEVCHAIWETTHDLISKWKVQWRVIISKCGSMDQVEIGFWQGLAQTESTAKVSLTLISVDTNPSLQLLPPAIRISATASSAFYTTPVSTPQASMVSPEQSGTPVTPMKETNPVNAATPGGTSGEPAEPAEGDAILLDVTDQTWGAILGHRLSSSPSLGELSPSLASGYLIKRGGTKLEDPPVTMEVNIVHVDHGSPRNYEGTLREMLNYFRGLGTVARARGVVDRETDIRPWHIAAAEKGVRALYLLM
Length1521
PositionKinase
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.06
Grand average of hydropathy-0.286
Instability index49.69
Isoelectric point5.10
Molecular weight164457.53
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31933
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.19|      13|      18|     582|     594|       1
---------------------------------------------------------------------------
  582-  594 (27.49/14.47)	LPDLGMPDAPPM..P
  601-  615 (21.70/ 9.66)	MPETAHFIAPPLeqP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.85|      41|      44|    1099|    1141|       2
---------------------------------------------------------------------------
 1101- 1141 (71.15/50.58)	LLSASATEKNFVVYFVYPPD...RPGSVVEECI..AFQQLFEIYKR
 1143- 1188 (56.70/32.27)	LAEKKQTPVNELVLQLVPLDfliSTAGIVEPTPsdAIKLALETYDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     390.99|     166|     231|     386|     580|       3
---------------------------------------------------------------------------
  386-  487 (77.49/59.77)	...............................................................................................................................................PPLLAQEQisdfLTEAR.TWFQNGTDRD..EKIAKRRkeREIAASKEASAATSAPAqqpnghsPLG.LRR..ASNAAASGAMYptppDGVQ.NPlgITPSMDGTTSSPG
  488-  710 (227.43/118.16)	APNATLAvadiDTTMMDHSAPDITmPNTG...PHGEAYGEWVSAAdnkreRAESFLGG.ENDNLFGDMG..ADLFVDA....AVTDADFSFFDEEPGDDLDLSglpdlgmpdappmpsalppvmpetahfiappleqpktepsPPVFTKPE....LKHARsTLMEEGRQRSnmEKMGSTK..RETSPFDPDTVYKRVRA.......SLGdIRStpSANPARKGSIF....DSVDfDP..VLPLVNKKYEQGG
  715-  807 (86.07/30.59)	NPFSQGA....STEASAHVVPQVP.PTTDylrRHGKNRRPLTANA.....LIRTITGGlENAGFNSSPGkvEELASDAddisLISDQDSNSTTDEPASPFKSS.....................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.92|      69|     231|     957|    1041|       4
---------------------------------------------------------------------------
  130-  214 (102.08/50.51)	LSLRNAQSATPGPPSSSEAdidSKSGADGKGTGfvsPKDAYDHFITAV...LATISAAFCNRssaiplnyrsVLLPSKV.ARDSQAEGP
  957-  973 ( 1.99/ 9.90)	........................................................................RLHPKPVpTRDSKAEPP
  986- 1041 (77.86/52.39)	LELRRAESRLSILPSSVQF...WESLGLGPAQG...PKDVSVVCVFPSwdgMADVAAAFLDR...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.51|      69|     989|     300|     377|       6
---------------------------------------------------------------------------
  300-  377 (109.67/91.07)	WRssdarsSQWR...DTC.....VKILQSRGLSPTllHSCSWIALQMLR..RKPgDLKADGKATPLNSTFATISWPAILCFRKKSVVS
 1291- 1369 (103.84/64.93)	WK......VQWRviiSKCgsmdqVEIGFWQGLAQT..ESTAKVSLTLISvdTNP.SLQLLPPAIRISATASSAFYTTPVSTPQASMVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.55|      12|     230|     830|     845|       7
---------------------------------------------------------------------------
  830-  842 (17.97/16.79)	VEDGDPtLALDLP
  858-  869 (23.58/ 7.67)	FEDSEP.LPIQLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31933 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADFSFFDEEPGDDLDLSGLPDLGMPDAPPMPSALPPVMPETAHFIAPPLEQPKTEPSPPVFTKPELKHARSTLMEEGRQRSNMEKMGSTKRETSPFDPDTVYKRVRASLGDIRSTPSANPARKGSI
2) ASDADDISLISDQDSNSTTDEPASPFKSSIR
3) GGRFDCNPFSQGASTEASAHVVPQVPPTTDYLRRHGKNR
4) GTDRDEKIAKRRKEREIAASKEASAATSAPAQQPNGHSPLGLRRASNAAASGAMYPTPPDGVQNPLGITPSMDGTTSSPGAPNATLAVADIDTTMMDHSAPDITMPNTGPHGEAYGEWVSAADNKRERAESFLGGEND
5) VSTPQASMVSPEQSGTPVTPMKETNPVNAATPGGTSGEPAEPAEGDAI
564
779
709
408
1360
689
809
747
545
1407










Molecular Recognition Features






MoRF SequenceStartStop




NANANA