<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31929

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVVNGAQRAQRAMLGWYRFIGQSLAHRLDPDKFAAYVPYLQAKHQLVPSVVADLFLRPQPHNHESLDPRVPRYLQVLSDLGYIDTPSILKAMYRYSTSRAHARNTAPVTSDSKQKPAIPRWTNSYAAEEVMFYRLTKSVAQGMALPDTETGIEVANIMAKWIALFTDAATAFTVDVTGQLQTSQAREEMESARAAFVALLLGICENQLVLKALSKPESKSVLPPSSMTHAGKTNTLEGTRKALSESLANFVPTIMQNAGPIATRLDMFRTSTLAGFEPIDEQKNTTNAEIEDLFDSAVALENFVVSDLPIINTRAGLYIYLNAALVARPLFDDMAMFNYLNNRYQGDVQTTTIDLILASFDVLANAVSRNEGNPTVQLLRSFLMNKVPLLIENLSKHMYPPLTAEFCITEALGRVDTNTFPTLSSMFDENRHNNPFTDSAREEFCWACCLHGLVRESSIENLLGETPYQSLPAGGRYVKSSLVADCLSDHERLQALIGELESKDGNAGAVCQALTEVLFPHPQRQSPPYLPRQVLGQLCRNKDTMTLKLLCGQLAQKPLSLDVMMLFEKPATVLHPLCDLLDSWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYNLSPSDLGITSPDSFVSRLLGQGHQSKPFDELTDQEKAHLNGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFQHIVLAFSTGHLSEESLKGGVEYLVDTFLVPSMVVAITYLANSLSVERSECQKAIIRVLQSVLTPNSISNEATAMLISVMNMIAKPLEHALGTYQRSDPKSQEVGPLLKAIEESVSLSRRTGAADHVELDAWANVPPAGFSSALRQTVHSLVRWSMNPAVDKLPPSYTHRQVLVGSNVLGAKRLLQLMYEDVRQQTDSGSGSIVYDVATALICAPDATSYPSPSLGFLDNTGSMPPSVQRRLSLREVLKQDAENCKRLQKTDMSLAETVVRLHRRVEHQLTVSQAAAIHAGTMLQSDLGLGLGPSAGSLDDAMAAAAANVVPGDGMSVDNVSLDLAMGGVGGDMGLGGASNSAGGSLDLGDGDLFSSIGGIDTSSDFQWDNMDMS
Length1078
PositionTail
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.07
Grand average of hydropathy-0.108
Instability index45.63
Isoelectric point5.10
Molecular weight117692.44
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31929
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.07|      34|      36|      25|      58|       2
---------------------------------------------------------------------------
   25-   58 (60.62/39.95)	QSLAHR.LDPDKFAAYVP.YLQAKHQL....VPS.VVADLF
   62-   96 (39.13/23.01)	QPHNHEsLDP.....RVPrYLQVLSDLgyidTPS.ILKAMY
  701-  732 (43.32/26.31)	.STGH..LSEESLKGGVE.YL.VDTFL....VPSmVVAITY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.60|      24|      36|     408|     438|       3
---------------------------------------------------------------------------
  399-  426 (40.09/38.23)	KHMYP...pltaEFCITEAL.GRVDTNTFPTL
  434-  465 (36.51/17.76)	RHNNPftdsareEFCWACCLhGLVRESSIENL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.98|      23|      25|     992|    1016|       4
---------------------------------------------------------------------------
  994- 1016 (39.08/20.45)	GLGPSAGSLDDAMAAAAANVVPG
 1018- 1040 (40.89/16.24)	GMSVDNVSLDLAMGGVGGDMGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.85|      22|      25|     250|     271|       5
---------------------------------------------------------------------------
  227-  242 (20.06/10.93)	.....PSSMTHAGKTNT.LEGT
  250-  271 (40.75/30.65)	LANFVPTIMQNAGPIATRLDMF
  276-  297 (34.04/24.26)	LAGFEPIDEQKNTTNAEIEDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.49|      14|      26|     544|     557|       6
---------------------------------------------------------------------------
  505-  517 (19.88/11.15)	SKDG.NAGAVCQAL
  544-  557 (23.34/14.44)	NKDTMTLKLLCGQL
  571-  584 (22.27/13.42)	EKPATVLHPLCDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.95|      17|      34|     796|     812|       7
---------------------------------------------------------------------------
  796-  812 (27.63/15.91)	EVGP..LLKAIEESV.SLSR
  827-  846 (20.32/ 9.87)	NVPPagFSSALRQTVhSLVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31929 with Med5 domain of Kingdom Fungi
Unable to open file!