<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31926

Description Mediator of rna polymerase ii transcription
SequenceMPSPASSPFTCTFCWQPSNGPAKAIGKSARLSCSPCYAALIDLAICWVCGEIVYRGEECVSLGWCFWHRACYGCMFYGSKIIFRGVPIAKLFNGRGETVHQGGKTGREVEEPPICAACAVSIEGADVVQASLRRVEQADGGLSRQRWEARKGAAGQLRRAPASIRTFSLRRAADGPRDDGIDNIVPASLESPVYVSMVDPLGVSTFRPSPTKPIPSWMHPHRQTQPVEGGNDGFGAQTRRVHTSTSTSDASTTKNLSPKHSWPPTPSSRPSSPPNIAAEASDFGRVQQHGWVSNEPLVRPSSRLVSRLEKTDTTTASGYVTPPETPSELANRYKTPPPQLRHVRPQSPLTQARLPPRKIILRTPPPQSSEYIEKYNPIRLPSPTLRARQPAVVTWKRSAHSRPSVGLVRESVIATEGSSSNRGGKPWETVGGNGTVPVPEVTPRKNAIAWKKRLFGETYSASSRLVVSFAIASPSTTSALNRQQQLTSTDAAQQQSQNKSSLPPIMAPLEPTSAELELQLKDTIQDLYQIMVQVTTYNTNTSPPSATALTESVQALSSSLQRVHRTAQAGAPLGPDLPGPLPKIPPELVQYVENGRNPDIYTREFVELVRRGNQLVKGKMNAFAQFRDVLAEHVESAMPECKEDVKMVLDSARAVGSGKPGN
Length662
PositionMiddle
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.06
Grand average of hydropathy-0.472
Instability index63.06
Isoelectric point9.52
Molecular weight71920.64
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31926
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.31|      25|      27|     332|     356|       1
---------------------------------------------------------------------------
  255-  280 (34.38/12.38)	NLSPK...HSWPPtPSS.RPSSPPNIAAEA
  328-  352 (43.10/17.27)	ELANR...YKTPP.PQL.RHVRPQSPLTQA
  353-  378 (23.84/ 6.46)	RLPPRkiiLRTPP.PQSsEYIEKYNPI...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.80|      24|      26|      46|      69|       2
---------------------------------------------------------------------------
   14-   44 (27.68/13.69)	CWQP..snGPAKAIGKSArLSCSPCYAAlidlA
   46-   69 (51.81/31.76)	CWVC....GEIVYRGEEC.VSLGWCFWH....R
   71-   95 (31.31/16.40)	CYGCmfygSKIIFRGVPI.AKL...FNG....R
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.78|      23|      24|     381|     403|       3
---------------------------------------------------------------------------
  380-  402 (40.29/24.50)	L..........PSPTLRARQPAVVTWKR.......SAH..SR
  403-  425 (25.39/12.42)	P..........SVGLV..RESVIATEGS.......SSNrgGK
  426-  464 (25.11/12.19)	PwetvggngtvPVPEVTPRKNA.IAWKKrlfgetySAS..SR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.35|      20|      24|     487|     506|       4
---------------------------------------------------------------------------
  487-  506 (33.95/25.25)	TSTDAAQQQSQNKSSLPPIM
  512-  531 (32.40/23.76)	TSAELELQLKDTIQDLYQIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      10|      26|     290|     301|       5
---------------------------------------------------------------------------
  290-  301 (16.00/14.21)	GWVSnePLVRPS
  318-  327 (20.81/10.94)	GYVT..PPETPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.29|      35|      36|      99|     134|       6
---------------------------------------------------------------------------
   99-  134 (57.79/39.61)	VHQ..GGkTGREVEEPPICAACAVSIEGADVVQASLRR
  135-  171 (56.50/34.22)	VEQadGG.LSRQRWEARKGAAGQLRRAPASIRTFSLRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31926 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SALNRQQQLTSTDAAQQQSQNKSSLPPIMAPLEPTSAEL
2) STFRPSPTKPIPSWMHPHRQTQPVEGGNDGFGAQTRRVHTSTSTSDASTTKNLSPKHSWPPTPSSRPSSPPNIAAEASDFGRVQQHGWVSNEPLVRPSSRLVSRLEKTDTTTASGYVTPPETPSELANRYKTPPPQLRHVRPQSPLTQARLPPRKIILRTPPPQS
3) SVGLVRESVIATEGSSSNRGGKPWETVGGNGTVPVPEVTP
478
204
404
516
368
443










Molecular Recognition Features






MoRF SequenceStartStop




1) AWKKRLF
2) PAVVTW
3) PLTQARLPPRKIILRTPPPQSSEYIEKYNPIRLPSPTLR
449
390
348
455
395
386