<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31924

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTDAKMPLMLENGMSDAMQVDQLDVDDLFGDGVGVGVGLSLQTARPLSKQLRQRIDDLRTRGCCQTVAWSKSGVIASVSPDGMSLETRFLRSHPDDGDWGLSEPTKIDLITTHPSSPIVHLSWAGTASPELAVIDATGRVSVLTYSVNLNRPFLTRRWDADSLDEFHAVVGCYWLPLAPGPQGKQYYISHGPAVKEGASYRYESSAVHAFGPCHPNSSKSALLCVSTNGAMKMYWAQNNNRIEESSIELESVNSSDDLVTHAALHSDKNLLWVVLATASRQLKVVRVQIKWGLPQSNSDNRPPPGSQSLNPSLQEKHVAISSWAPNGPTTSPLDSAMTQLTHLEILPSTMDPSGQAWAPLAILAVRTYLPTPNTPYQEPQSIVDKWEVVNDQAQNLHPAFEQLGSRRNSTSTGSAPAPMSHLKKCDSVAINKIIVGVHPLQFGKVICLVFSDGSSEYRDRFTLQKIYNETNLDRIMTLNQVGFTFQDDSHCLQAALSPTNCSLVKIQDDGKVKWSRLHYALGDIGNSAKDAQYAAVLAGLTVAASTATFHSINYDDILAVARPFADKPRFAYDWINEVVRMLKIPVDYSEDTHHDSLVRNAPLQMCLSILNHLGYKGMFQPRSFGGKFAMLALNARNIVILITIASNTPVTIREKLSPLDEHEVVDALAGCAKWCLDLLSWLTDSVFSLLDDAQFQALLTPQRFSELSAYLQSRSDVSLHFLLCSSTRGFLSAICRRILHLEILSNRAIDFYERRAHDPSSSQNQKVVQVALHKAYQKMQRVTSQSLIKTQEFDRLLTVLSTDIRAAYQTSFASLATTGHSSHNNKNQASGGKAVDAQMKAAQVRCELGMLLASNPPAPLLGVLTKFFNTDLRAYRAQTDPAKLFFGDFELLEIDDDGRSLAARKAKGRFIDNFKRVELVGPPPAAKMGGEESGGGGGGGGGRTQWRRCVRCSAVMEDASGSRPGYTFVLAQQRKCSCGGHWALLPRGTLVS
Length992
PositionTail
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.07
Grand average of hydropathy-0.221
Instability index43.11
Isoelectric point7.34
Molecular weight108754.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31924
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     425.96|     140|     201|      56|     220|       1
---------------------------------------------------------------------------
   56-  220 (220.71/145.76)	DDLRTRGCCQT...VAWSksgVIASVSpdgmsletRFLRSHPDDGDWGLSE........PTKIDLittHPSSPIVHL...SWAG...TASPELAVIDATGRVSVLTYSVNlnrPfLTRRWDAdsldefHAVVGCY.WLPLAPGP.QGKQYYIS............HgPAVKEGASYRYESSAVHAFGP.CHPNSSKS
  256-  427 (205.25/95.79)	DDLVTHAALHSdknLLWV...VLATAS........RQLKVVRVQIKWGLPQsnsdnrppPGSQSL...NPSLQEKHVaisSWAPngpTTSPLDSAMTQLTHLEILPSTMD...P.SGQAWAP......LAILAVRtYLPTPNTPyQEPQSIVDkwevvndqaqnlH.PAFEQLGSRRNSTSTGSAPAPmSHLKKCDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     340.55|     110|     158|     496|     618|       2
---------------------------------------------------------------------------
  496-  618 (176.56/144.67)	LSPTNCSLVKIQDDGKVKW..SRLHYALGDIGNSAKDAQYAAVLAGLTVAASTATFHSinYDDI......LAVARPFadkprfaYDWINEVVRMLKI....PVDYSEDTHHD.SLVRNAP.LQMCLsilnHLGYKGM
  656-  779 (163.99/107.12)	LSPLDEHEVVDALAGCAKWclDLLSWLTDSVFSLLDDAQFQALLTPQRFSELSAYLQS..RSDVslhfllCSSTRGF.......LSAICRRILHLEIlsnrAIDFYERRAHDpSSSQNQKvVQVAL....HKAYQKM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31924 with Med16 domain of Kingdom Fungi
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