<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31921

Description RNA polymerase ii mediator complex component srb8
SequenceMTSRTPMGVQPRPPPQQRTLSSSGLSVQRPNHQRTLSAQYLPQSPVRKDNLIDLTGDSNDAAVAQNRYGSLPRRGGSRLKLELSNDAMLPQHPVANSPNTLTPSRLMPKSENPNITDMSSPASARGQHVDNDNPRMPFPKRRPQFAAPVSAKEPPPPALPVKKDGRPKPYHLETPPAAPRYGPLGKPRPEAMAKQGFGGSAGSARDSQDIRHADFFAWAGNHPEDQWSETIIKNGYFDKPPATTTETSTAKAVMVPFLKQKSGAQFLSTLFYGVLHQRKVNGQITSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGRVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPSVAMSGEAKWLRDWTVFVEQFVENVSTAFGENDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILVTQIYWKDLLKLRKYGRRLTNALLNHLNSIHIDPDRDILMSLSTRLTSLLAPLLSACPDNFVAPLSWFKYRDALQAYIPIENENAHSACRLITMRNEQLVASSNNSQPANRQILVKHLDTTFLNLYTPDLAARCWAISEDKSMIVRTLLEWCTSPHRPGSSKVYITAALLRAWIPTGIDVTSAILEFLSNNPPSEKNAKKALHKLVSEIARSGDFQFQGYVFWLIARGGLRSPADTEADGSCATRLLVDLPLHALSPASLTTRASLLRRASFDVNVEAEDINIALKCVQHALGLPLPPGDPILQKPVPLAKLCRLVANSNRALQTEVGARLLQIFTNDLITTKNGPQVSATMFNVTRAVLEAACDYTVLVEIVKIATRVSNPEILASCADTVNVHLPIFAALGASKETFDILMDRLKVVGEEQGIAAAPLLASLSDLAARLPGLTNTAAHLRKELQQCDRNTAIDACSPVSDNMAVQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLEASWSNSPDRQRAYSALLGRLRIFDSQHFDVRMTDWVHHVGALKVRPGLVDIYPLLISMGCLTLRIILTTTTVDPSRVAANPSAPTASTTTYMQEVLHLATMPLPTKTALSAEEACRFYIQQRLVPRQNHKDMVCLLRNALVEFSRLQNQPGLTLPLAKPSLRLGMLELIRLLVLLDAPSVVQSLSLKTSEPALSALFGQITTSLLLPDAGDGSSLTFETVLELANEFTLPFCQLKLSIGLTADTTTSPGGGEQAMSQFDMFSRAMDRAVSANNVMWTSMLPYLNEEVTEHLKRQAHLRFLGLFPSQKNAPASNPLSEESIKLAGSLLSVVEAIVRGRPAPRTSQLTSGMVEKLTELWEILASVGDDKRELRNSILRHWLPVLLRFITLHTNANESIPALVQATGIAKTSASAAAAEIRGRILVVLSGLTLELDNLTLDTLPVGRPLSAQVFDLALLLVDSLPEDTRLQCVRVLLTGGTAQCPASSDARLRYLFSQMPSTTEHWALAHRNQPTTQQPGPPRQKMPISVSMQATENKITPFVFRKWEMLSEPTPNVGENDTALSLTLFEAIKIR
Length1537
PositionKinase
OrganismColletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422) (Cucumber anthracnose fungus) (Colletotrichum lagenarium)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum orbiculare species complex.
Aromaticity0.06
Grand average of hydropathy-0.190
Instability index46.19
Isoelectric point9.09
Molecular weight169526.94
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     496.42|     178|     225|     844|    1068|       1
---------------------------------------------------------------------------
  844- 1064 (242.55/223.11)	HLPIFAALGASKETFDILmdrlkvvgeeqgiaaAPLLASLSDLaARL...PGLTNTAAH..LRKELQQCDRNTA.IDACSPVsdnMAVQLQDAEGELHEEIEKLLTSGTSVDRPTMDRL.FQTV.................VGrLEASWSNSP.DRQRAYSallgrlrifdsQhFDV..RMTDwvHHVGALKVRpgLVDIYPLL...ISMGcLTLRIILTTTTVDPSRVAANPSAPTAstttymQEVLHLA
 1081- 1288 (253.87/138.91)	RFYIQQRLVPRQNHKDMV...............CLLRNALVEF.SRLqnqPGLTLPLAKpsLRLGMLELIRLLVlLDAPSVV...QSLSLKTSEPALSALFGQITTSLLLPDAGDGSSLtFETVlelaneftlpfcqlklsIG.LTADTTTSPgGGEQAMS...........Q.FDMfsRAMD..RAVSANNVM..WTSMLPYLneeVTEH.LKRQAHLRFLGLFPSQKNAPASNPLS......EESIKLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     200.66|      64|     138|      11|     148|       2
---------------------------------------------------------------------------
   73-  148 (94.90/136.43)	RRGGSRLklelsNDAMLpQHpvANSPNtLTPSRLMPKSENPNITDMSSP.ASArgqHVDNDNPRMPFPKRRPQFAA..P
  462-  528 (105.76/35.42)	RKYGRRL.....TNALL.NH..LNSIH.IDPDRDILMSLSTRLTSLLAPlLSA...CPDNFVAPLSWFKYRDALQAyiP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     165.05|      40|     138|      13|      66|       3
---------------------------------------------------------------------------
   13-   52 (69.72/28.97)	PPPQQRTLSSSGLSVQRPNHQRTLSA..QYLPQSPVRKDNLI
  154-  193 (64.40/25.70)	PPPPALPVKKDG..RPKPYHLETPPAapRYGPLGKPRPEAMA
  240-  267 (30.92/18.61)	.PPATTTETSTAKAVMVPFLKQKSGA..QFL...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.18|      27|     382|     313|     354|       7
---------------------------------------------------------------------------
  324-  350 (49.52/42.60)	IPHGIRGRVLLDHCLNKNVPTERAVWL
  595-  614 (28.70/ 9.68)	.......RTLLEWCTSPHRPGSSKVYI
  623-  645 (31.96/ 9.09)	IPTGIDVTSAILEFLSNNPPSEK....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      25|     238|     539|     583|       8
---------------------------------------------------------------------------
  539-  573 (33.00/30.30)	RLITMRN................EQLVASSNNSQpanrqilvkhLDTTFLN
  763-  803 (30.54/24.81)	RLVANSNralqtevgarllqiftNDLITTKNGPQ..........VSATMFN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31921 with Med12 domain of Kingdom Fungi
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