<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31907

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASITFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDADRVGIWIFQIVSKDGTSKAVNSAPGSSLEASGYTLGMVEEGNLEPVALQKSRIPGNTTQNAPNNTASTASPAEANSRNPLISPTQVAGGALPEGVSQSSAQVTDMRTTQPVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLLADANERERGSLQADPVVGTFKTYLTTTGSLVVSLTFSYCKNLATVEDVLTDTNDSQWKHSCLKALEYCGLNPSQFKASPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPMEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRKAERMYAVTREVNGANPLAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGIAPSIDGAISSPNNPPPTLAVVDADMTMPTATPMADAENDAWGGQHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPVLSHPEPHKAIQPQPEVKPKPKTNDSVFAKPELKHARSSLNDELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDFAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQSNGDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGIDASTTHASPQRLNGHDWISEESELESDGDDISSLSGGPVSPVKSSIKRTVVDDDALSQATTSRETELLDDVTDEQLAIELPKLSKTESPEMLLHRFFLDPEPLNVDVGLSNHDFVEIAQIITEQAATGRLEIGIEHKAESSVSLATMRSHELSIARNSLQLLHDAIHSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGTKDISALCIFPGWKGMSDHVESFLSRLKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGHGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSHHKAAIIAEIWATTLTMISIWKVHWRVIITKSGAMDQKEVEWWQAASTLDDKHSFTMILMSVDTNPSLQLVPPIVKIPHAATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGIKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1466
PositionKinase
OrganismFusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.379
Instability index47.55
Isoelectric point5.20
Molecular weight160398.72
Publications
PubMed=24743270

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31907
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.69|      41|      88|     184|     228|       1
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  184-  226 (69.17/40.29)	AFAFC....SRSMAIPlnYRTMLI.PPLLADANERERGSLQADPVVGT
  271-  316 (66.52/25.29)	ALEYCglnpSQFKASP..WVNLLIsKPTSQDADGESKRSRATVPWPGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.02|      14|      86|     427|     450|       2
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  427-  440 (27.63/ 9.33)	DGAISSPN...NPPPTL
  523-  539 (23.39/11.82)	QPAPTAPApqvMPPPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     321.45|     108|     616|      29|     170|       3
---------------------------------------------------------------------------
   29-  157 (157.31/121.01)	DQSHG.FQSSALEIQSS..LRDQGKLVSYDADRVGIWIfqIVSKDGTSKAVNSAPGSSLEASGYtlgMVEEGNLEPVALQKSRIPGnttqnapnntaSTASPAEANsrnplISPTQVAGGALPEGVSQSSAQ
  660-  770 (164.14/86.31)	DQSNGdSRPSAHNLSRDeyLEGQGKLKQTSKSLLGNSL..IRSLTGIDASTTHASPQRLNGHDW...ISEESELESDGDDISSLSG...........GPVSPVKSS.....IKRTVVDDDALSQATTSRETE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.41|      55|     615|     323|     419|       4
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  323-  396 (76.47/116.73)	PMEMSTTHrvgdtmlsgheechdPLGDARGWFAGASEREERisKRKAERMYAVTREVngANPLAQNLNGQSPLT
  446-  500 (98.95/51.28)	DMTMPTAT...............PMADAENDAWGGQHEQKR..ERSDSNAMGDSDDV..MNDLGEDVFGDHDVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.60|      60|     298|     894|     956|       5
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  894-  956 (103.19/71.44)	VGQPSRLQPRPI.PGRDPNAEQLRANNLYQIPVPHLEVRR.SETKLSVLPssmSFW.EGLGLSPSW
 1179- 1241 (93.42/57.14)	VGYAESLDGRWItAAWTDNRGQRQATTSYSITRSRTPDRSvSHHKAAIIA...EIWaTTLTMISIW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.11|      29|     294|     546|     577|       7
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  547-  576 (47.65/38.12)	AIQPqPEVKPKPKTNDSVFAKPELKHARSS
  579-  598 (25.98/17.38)	.....DELNHRIKVE.....RPDTAKRGSS
  622-  638 (23.48/ 8.08)	AVQP.......PRRKSSVFEKVEF......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.73|      20|     895|     400|     424|       8
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  400-  420 (34.65/21.68)	PStAAAGVMYPTPPDAIQQHI
 1298- 1317 (35.08/16.43)	PH.AATSAFYSTPVSTPQANI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31907 with Med13 domain of Kingdom Fungi
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