<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31904

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTVLNSDVEDGSGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFSGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTRQEQIQWISDLDTQLSLRLNLEDFDKIPYHFRNYEIDSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFEPAASSIPDGLKNYLEGQVNDILSKDGLLGCYQFLHELVLTHKLNELKRQAIQLSRGSWTGTLKVEPLNRALAIQYWTSRAQLGSPKSWILIAVNSGRKPNGQPDPKSSSHLMVKWYRDNKEVKDTNISFDADNLSAETLLKTVIGRHVEFLLGSIHSRLQAFPRFQNRDAAMILNISHDDPATSFLSMQVGYKDSASLLVEPTTGVFAVKPHSKFTIQHEHLLNNGKNPADDGATCLENVRCGVMEDELIRRGSTTGWNTKKSPLSKDELRSLTNTREWTKTIWLQRTGWDPNWFVMVMLSPSGDAWWLVDASRNVNGQSNRLSSKLPLNKGYPHLEDEFWNNLTLFATGMIAQAVDQHELYRHNIKFLLQDTRNWSLPQQVRLPTLEISLSDIFPSMVFNMAEKDNAKAANESNAGTETARFGPVAPTASTPGISTRQPWAHDIVSIRFKGVEPVDKEASGAGGPISDVSFMCISDAIIKVRKPTKFAMLKGHMTVEDAEVSRLWRVALNLSNNDIDIQVQETNPHLPVTDLMQKLVNGANGIGALMDWLPVSLPTMEAFKKIREAWSDIEARRQGRFKFIMNSTDEMSFQYLLAGTGPGNQQVQRSITFLGQIKQRRGEPWWHIERKIPSSGWPSLNDEFSAALKPVWDGKGDDWSGLVTGATGRPENGIIGLLLAIDEAIRPLAGSTFQNNSEVVILE
Length945
PositionTail
OrganismFusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.08
Grand average of hydropathy-0.333
Instability index33.42
Isoelectric point6.11
Molecular weight105904.19
Publications
PubMed=24743270

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31904
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     265.12|      87|     128|     618|     710|       1
---------------------------------------------------------------------------
  618-  710 (137.15/108.25)	RNWSLPQQVRLPTLEISLSDIFPSM.VFNMAEkdnaKAANESNAGTETARFGPVA.PTASTPGiSTRQPWAhDIVS...IRFKGVEPVDKEAS....GAG.GP
  748-  844 (127.97/83.21)	RLWRVALNLSNNDIDIQVQETNPHLpVTDLMQ....KLVNGANGIGALMDWLPVSlPTMEAFK.KIREAWS.DIEArrqGRFKFIMNSTDEMSfqylLAGtGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.15|      24|     300|     570|     604|       3
---------------------------------------------------------------------------
  570-  594 (44.72/32.13)	KLPlNKGYPHLEDEF..............WNNLTLFATG
  873-  910 (39.43/11.57)	KIP.SSGWPSLNDEFsaalkpvwdgkgddWSGLVTGATG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.34|      25|      50|     180|     204|       4
---------------------------------------------------------------------------
  180-  204 (44.64/28.39)	DLDTQLSLRLNLED.FDKIPYHFRNY
  216-  236 (29.97/16.66)	AGEFEVDLTIADED.FEK.QFWF...
  238-  257 (28.73/15.67)	D......FRFAFEPaASSIPDGLKNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.37|      23|     216|     328|     352|       6
---------------------------------------------------------------------------
  328-  352 (40.65/28.75)	SP..KSWILiaVNSGRKPNGQPDPKSS
  545-  569 (39.72/22.20)	SPsgDAWWL..VDASRNVNGQSNRLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.85|      15|      18|     490|     505|       9
---------------------------------------------------------------------------
  490-  502 (18.45/ 8.13)	.......EDELIRRGSTTGW
  504-  523 (19.30/10.96)	TKksplsKDELRSLTNTREW
  524-  538 (30.10/14.94)	TK.....TIWLQRTGWDPNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.89|      17|      23|     136|     158|      10
---------------------------------------------------------------------------
  107-  126 (25.53/18.61)	DLRFHLQgqeVLFSGALDVM
  142-  158 (30.37/13.07)	DLKTALQ...VLSTGEAAWM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31904 with Med14 domain of Kingdom Fungi
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