<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31903

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVASQPRFAPRITATAPAPAKKDARPKPYTVEIPSVAPRYFSANRPETAVRNPVDPFSKGLNSGYADFFPWNGAHHEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVAGFGENDWKNRVTYAIRLATNLYSEQLLDRDHYLDWVVSGIENSLQSRIPMWLLIAQIYWKDLLRSRKYGRRLVFALLSHLHVISNDPDQDLLVQLSSRLSALLGSLIRSNPESFINPGAWSTYKDTLHACLRSDDEQARKALHAINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESSDNHLAAACWATSENKSLIMKTVVEWATSFHRPGLAKVYAATRLIRQWSQFRVNPTTPILETLDNIAANDKARKNLVYHLVTELVRTGHFSVSQYMQWTIARGGYHCAAEIDPVSGPCSSRLLVELPLHALSEKRRAERGNLLRRAGNYSVAEEDQDITNAIRVVKHVVGLPLLSNDPLSGRKPMSLKKLLQRMGGSSTALRSSIGAHLRDELTGQFIMKGHSLSLTMFTAVRDIMETAEDYAMLSDILGACAKTADSDVLASVADTVHSNLQIFCALDSANELFNSLIERLRMMNEEQRLVPRPLLAALSSLAQRMAGHEVIASQLRQDLVQNDRNNAIDACSPVSDIVATPSHQAENNVAEEVERTLSSGTRLDPPTMNKLFRMIIPALERGWEKEDDTRRVFATLLARIRVFDAHHFDKLMTDWTSHIRSISNRSSLSTLFPLLIITGCLTMPIIMSTASPPFANIQNLAPESSRGPATYLQELLQLVIMPLPQATGLVAEESYRFHTEQKCAKFEQSKGLLNLVRNALLEYSTSARDLTNSCSGGFLRRLKCFRHQIATKLLIPGDSGETQISFDHILQIANELTLPFCQLKLNLDLSLPQPSVIEGQDQSSSRFEIFARAMDRAIEAGNIMWTSLLPCLSDDITQHLKTQAQTGFLDLIPSSKAPEFVDTGSRQSLRMAENLLEVVEAIISGQAPPKMAQLSLGMVEKLTDLWEIVAAGPQERPNCHAAVLQHWLPAMLRFVNLHSLSSEPPSAPLPTASATRPPIPPVHDVRARIVLVLCGLLLELETLPPATVGSLVQQVFDIAILLVDALPEELRANCARATLLTPGGMPNQGTSSDPRLYYLFSSPPPSPSDNLMLSHREKAATPQSAAARGMGAQYGIGPVVQERLSPFILRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1487
PositionKinase
OrganismFusarium oxysporum f. sp. cubense (strain race 1) (Panama disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.06
Grand average of hydropathy-0.219
Instability index53.12
Isoelectric point9.05
Molecular weight164018.90
Publications
PubMed=24743270

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31903
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     258.72|      92|     101|     762|     862|       1
---------------------------------------------------------------------------
  741-  799 (51.06/38.56)	............................................SLKKLL.QRMGGSS..TALRSSIGAHLrDELTGQfiMKGHSLSLTMFTavRDIMETAEDYAM
  800-  895 (142.82/92.63)	LSDILGACAKTADSDVLASVADTVHSNLQifcaLD..SANELFNSLIERL.RMMNEEQ..RLVPRPLLAAL.SSLAQR..MAGHEVIASQLR..QDLVQNDRNNAI
  901-  964 (64.83/32.52)	VSDIVATPSHQAENNVAEEVERTLSSGTR....LDppTMNKLFRMIIPALeRGWEKEDdtRRVFATLL......................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.05|      81|     101|    1121|    1216|       2
---------------------------------------------------------------------------
 1024- 1132 (101.66/68.23)	IQNLAPESSRgPATYLQELLQLvimPLPQATglVAEesyrfHTEQKCAKFE.......QS..KGllNLVRNALLEYSTS..ARDLTNSCSGGFLrrlkcfrhqiatklLIPG.......DSGETQiS
 1136- 1235 (116.40/90.51)	ILQIANELTL.PFCQLKLNLDL...SLPQPS..VIE.....GQDQSSSRFEifaramdRAieAG..NIMWTSLLPCLSDdiTQHLKTQAQTGFL.............dLIPSskapefvDTGSRQ.S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.47|      11|      67|      13|      23|       3
---------------------------------------------------------------------------
   13-   23 (21.97/11.05)	SSSSLPVQRPP
   82-   92 (19.51/ 8.89)	SSSSLPTSESP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.46|      39|      93|      24|      62|       4
---------------------------------------------------------------------------
   24-   62 (72.37/40.85)	PQR................SLSHQQQFMAAASPVRKD...APFIDLTADA...GDATPNRY
   97-  157 (52.08/27.21)	PSRipnsdpfqamvgspagSASSTLMPMPTRRPVASQprfAPRITATAPApakKDARPKPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      12|     101|    1304|    1315|       5
---------------------------------------------------------------------------
 1304- 1315 (23.23/11.99)	LHSLSSEPPSAP
 1403- 1414 (25.43/13.96)	LYYLFSSPPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.61|      33|      93|    1255|    1291|       6
---------------------------------------------------------------------------
 1255- 1291 (56.55/49.18)	PPKmaqlSLG.MVEKLTDL.WEIVAAGPQE.RPNCHAAVL
 1351- 1386 (45.06/29.06)	PPA....TVGsLVQQVFDIaILLVDALPEElRANCARATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.84|      24|     109|     497|     520|      12
---------------------------------------------------------------------------
  497-  520 (42.42/29.53)	WSTYKDTLHACLRSDDEQARKALH
  541-  564 (36.42/24.23)	RSQLVKLLDAALKESSDNHLAAAC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31903 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGAHPRPPQRSVSSSSLPVQRPPPQRSLSHQQQFMAAASPVRKDAPFIDLTADAGDATPNRYHTTPRRGGSRLRLELSHNASSSSLPTSESPQSLTPSRIPNSDPFQAMVGSPAGSASSTLMPMPTRRPVASQPRFAPRITATAPAPAKKDARPKPY
1
157










Molecular Recognition Features






MoRF SequenceStartStop




1) ARPKPYTVEI
2) FAPRITA
3) FIDLTA
4) RLYYLF
152
136
47
1402
161
142
52
1407