<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31896

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSALDGERSPKRQRLESYSPASPRPTSEPTKAFIPNYSTPPPSVRMSPSWTAQSQTTHQQQPASGGNFPSPPSTAGFQTRMAGRDGAESGGENGHQTPASQDDGEARKDGDGDSAMLDRQDSEGGHDGTPAGTEHRRSDHERQGGSGENTMTSSSAAAQLYRLPITPIAPSQPHPSQNLLALYELSDIQRRVARLDPAGNKIKLRKSYASKVKNLGLEGLNKAVPNQSELEGLVDPLWSSEVAPGLTMWDQRWQEFRLGDAAAETDLLGKLNSALQFQTGRLPKSEHEQWRKSLGLDEIAVAAKNAGVSRDPKQATASAHLARTAPAAALRSSAPSSPRNGARAVRTGKKRGYGDSSFEGYGEGFEDDVYSTDGVDDAGRRRDPNKRQKRKEFPSNTNTPAFSSGSGSGIGVRTS
Length415
PositionHead
OrganismSphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Sphaerulina.
Aromaticity0.05
Grand average of hydropathy-0.961
Instability index60.46
Isoelectric point8.90
Molecular weight44459.09
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31896
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     200.75|      83|     146|     137|     224|       1
---------------------------------------------------------------------------
  137-  186 (67.86/33.02)	..................................................................................................RSDHERQG....GS.GENTMTSSSAAAQLYRLPITPIAPSQPHPSQNLLALYELS
  187-  224 (21.22/16.85)	DIQRRVARLDPAGNKiklrKSYA.SKVKNLGlEGLNKAV..................................................................................................................
  284-  334 (55.17/25.28)	.......................................pnqseleglvdplwssevapgltmwdqrwqefrlgdaaaetdllgklnsalqfqtgrlpKSEHEQWR....KSlGLDEIAVAAKNAGVSRDPKQATASAHLARTAPAAALRSSA
  336-  404 (56.50/27.31)	SSPRNGARAVRTGKK....RGYGdSSFEGYG.EGFEDDV...............................................ystdgvddagrrRDPNKRQKrkefPS.NTNTPAFSS...............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.28|      21|      22|      47|      67|       2
---------------------------------------------------------------------------
   47-   67 (40.69/23.35)	SPSWTA..QSQTTHQQQPASGGN
   70-   92 (33.59/17.91)	SPPSTAgfQTRMAGRDGAESGGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.72|      16|      16|      94|     109|       3
---------------------------------------------------------------------------
   94-  109 (28.35/15.57)	GHQTPASQDDGEARKD
  112-  127 (28.36/15.58)	GDSAMLDRQDSEGGHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.85|      15|      18|      10|      24|       4
---------------------------------------------------------------------------
   10-   24 (28.30/17.81)	PKRQRLESYS..PASPR
   29-   45 (24.55/14.42)	PTKAFIPNYStpPPSVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31896 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DVYSTDGVDDAGRRRDPNKRQKRKEFPSNTNTPAFSSGSGSGIGVRTS
2) MSALDGERSPKRQRLESYSPASPRPTSEPTKAFIPNYSTPPPSVRMSPSWTAQSQTTHQQQPASGGNFPSPPSTAGFQTRMAGRDGAESGGENGHQTPASQDDGEARKDGDGDSAMLDRQDSEGGHDGTPAGTEHRRSDHERQGGSGENTMTSSSAAAQLYRLPITPIAPSQPHPSQNLLALY
3) VAAKNAGVSRDPKQATASAHLARTAPAAALRSSAPSSPRNGARAVRTGKKRGY
368
1
301
415
183
353










Molecular Recognition Features






MoRF SequenceStartStop




1) AHLARTAPAAALR
2) FQTRM
3) QLYRLPITPI
4) TSEPTKAFIPNYST
319
77
159
26
331
81
168
39