<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31894

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVISPSFAQRSVDHHSTMAGIYPTPPDGFAPGQPSALNSVVTPLATQPELNSSVAEAYAPNDELQPKAASRPAPSNEPGDHELAQEELFADDGGMAFGDAEIDDAEFDFFDEPDDGFVEHQAAQDSNMPDVSTYEDTEVLEAVSNLAQDEEGNHDPPVGIPPVLMPQQGLNDPTPMPMDTESDGLQSQEPAGNINPPIEHQPSLVHRPLSPFGIRERLLPPPVPASHSQPQSGSCGSRHDRRSSSFTPITFRDGVSATLQYGSVPKPQNVAQIDATGGSMGIGLHALQKKHRPFDDDDDSDADTISDSEEERDVTTTGDVRIVEPPPPLPWESKKRKRHGIPQAELLTSGPPTSAWLDEYEDEKKDGSPSVDTLLKVLLESTSPAVNLDLQATLTAEKALCDTGLPSAAAQPEALETLTGTVASIETAYSLTKSDLVCVAQIVSEQSVTANPHVSAMRRRFDDARDAVDDATSVTIPRYIRDRLSRAIRLACPEAAYCDLADLALAKDAPARQATVPGKIPQGQPRPPQRLDNIPTGPDMFPLPAPYIRLHRGTDTWELLPACIPFWEPLGLGPAAGPKHLRAFCVFPFNEDLQRLVDQFLRDVGTAYESCKLGTHIHLRNVSELEQDNFKDGLAPVELSEDASLESVLRAYAATCTDLGKALSSILPGEERAIVVYILNPFTGRDAQQHLCACFWMLFQAHRERTSKSPLEQDNSDIFLQILPMNMVASFDAFVPLDARKMSVLAREVYDRCPPTSAPLLSDISAPLPNLAAPTVELASTAPKRLGFQLASEAPGDLLYEGSILHLAYAHSSDGMWLTACWIDSTGKHQSSSSFGLAGRTFAEVAHDVWEFTRTIMAARQVSWRVFIVAPGADLDPSAVQCWRSVAARPRSHPVCVTLLSTQEDPFLQLYRPCESSCYGGGGGSNAEVGVLTPASTPQGATFTSSPDVSGHTSNAPPTPAASETANSLPTDGTGDSDAHLMDMTDETWGVLLSTKLLSDHHASSSSRMAHGVLFQRGPASMPDSEHTDTGDKLPSLGVNLHWTIQVKSQGGVDEGSAKQAELTLRDVLRMYRGLTTLTNARSLIRSAAAAAGTGKSILPVHVAMATMGAEGLVGLAPVVDDIS
Length1124
PositionKinase
OrganismSphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Sphaerulina.
Aromaticity0.06
Grand average of hydropathy-0.317
Instability index53.99
Isoelectric point4.71
Molecular weight120653.41
Publications
PubMed=23236275

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31894
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     277.31|      76|      84|      22|     103|       1
---------------------------------------------------------------------------
   22-   97 (100.67/60.89)	...........YPTPPDGFAPGQpSALNSVVTPLATQPelNSSVAEAYapNDEL....QPKAASRPAP.......SNEPGDHELAQEELFADDGGMAF
   99-  178 (128.10/64.29)	DAEIDdaefdfFDEPDDGFVEHQ.AAQDSNMPDVSTYE..DTEVLEAV..SNLA....QDEEGNHDPP.......VGIP..PVLMPQQGLNDPTPMPM
  179-  224 (48.54/16.57)	DTESD.................................................glqsQEPAGNINPPiehqpslVHRPLSPFGIRERLL..PPPVP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.42|      13|      15|     465|     477|       2
---------------------------------------------------------------------------
  465-  477 (21.59/14.02)	RDAVDDATSVTIP
  481-  493 (22.83/15.30)	RDRLSRAIRLACP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.57|      67|     263|     739|     849|       3
---------------------------------------------------------------------------
  659-  774 (88.27/67.39)	LGKALSSILPGEeraiVVY...ILN.PFTGRDAQQHLCACfWM............lfqahrertskspleqdnsdiflqilpmnmvasfdafvpldARKM....SVLARevyDRCPPTSAPLLSDISAPLPNLAAP
  786-  823 (38.64/88.75)	LGFQLASEAPGD....LLYegsILHlAYAHSSDGMWLTAC.WI.............................................................................................
  877-  913 (36.65/ 0.00)	...........................................dstgkhqssssfglagrtfaevahdvweftrtimaarqvswrvfivapgadldPSAVqcwrSVAAR...PRSHPVCVTLLSTQEDPFLQLYRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.92|      19|      22|     546|     566|       4
---------------------------------------------------------------------------
  548-  566 (37.40/13.76)	IRLHRGTDTWELLPACI.PF
  570-  589 (29.52/ 8.77)	LGLGPAAGPKHLRAFCVfPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.98|      21|      21|     945|     965|       5
---------------------------------------------------------------------------
  916-  942 (27.61/12.47)	SSC.YGGGGGSNAEVgvlTPASTpqgAT
  945-  965 (39.30/21.23)	SSP.DVSGHTSNAPP...TPAAS...ET
  968-  988 (31.07/15.07)	SLPtDGTG.DSDAHL...MDMTD...ET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.06|      25|     265|     255|     280|       6
---------------------------------------------------------------------------
  255-  280 (39.05/22.19)	VSATLQYGSVPKPQNVAQIdATGGSM
  516-  540 (49.01/24.47)	VPGKIPQGQPRPPQRLDNI.PTGPDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.28|      20|     265|     359|     378|       7
---------------------------------------------------------------------------
  332-  356 (28.16/18.35)	ESKKRKRHGIPQAELLtsgppTSAW
  359-  378 (32.12/22.13)	EYEDEKKDGSPSVDTL.....LKVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.62|      36|     405|     613|     652|       8
---------------------------------------------------------------------------
  613-  652 (51.35/43.15)	LGTHIHlRNVSELEQDNFKDGLAPvelSEDASLESVLRAY
 1037- 1072 (61.27/38.75)	LGVNLH.WTIQVKSQGGVDEGSAK...QAELTLRDVLRMY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.39|      11|      15|     422|     432|       9
---------------------------------------------------------------------------
  422-  432 (17.77/16.35)	VASIETAYSLT
  439-  449 (17.62/16.12)	VAQIVSEQSVT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31894 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEVGVLTPASTPQGATFTSSPDVSGHTSNAPPTPAASETANSLPTDGTGDSDAHLMDMT
2) DHHSTMAGIYPTPPDGFAPGQPSALNSVVTPLATQPELNSSVAEAYAPNDELQPKAASRPAPSNEPGDHELAQEELFADDGGMAFGDAEIDDAEFDFFDEPDDGFVEHQAAQDSNMPDVSTYEDTEVLEAVSNLAQDEEGNHDPPVGIPPVLMPQQGLNDPTPMPMDTESDGLQSQEPAGNINPPIEHQPSLVHRPLSPFGIRERLLPPPVPASHSQPQSGSCGSRHDRRSSSFTPITFRDGVSATLQYGSVPKPQNVAQIDATGGSMGIGLHALQKKHRPFDDDDDSDADTISDSEEERDVTTTGDVRIVEPPPPLPWESKKRKRHGIPQAELLTSGPPTSAWLDEYEDEKKDGSPSVDTLLK
927
13
985
376










Molecular Recognition Features






MoRF SequenceStartStop




1) DAEIDDAEFDFFDEPDDGFVEHQ
2) FGIRERLL
3) SKKRKRH
4) WLDEYE
99
212
333
356
121
219
339
361