<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31889

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMADLPDAAMMDGTMDDLFGEAPVGLDGSIAMPAAPLPASLVLRIAEMQSRGCCTKIAWSNTGSIAQISPDGTQITFRTMIRHKETAAWTISDASNYPFKAPEGRKFVHIQFSGIGLDLVVVDDAGHVHLPSVFGAIGRMSTTQGELARDDSKHELNAIVGLHWLALFPAEFRGPYIDAAHKNGDRWDATIKLRDQQGLRAHHPAEGRHAFLHISRSTELTLCYQNEGQGWQSTSVMLDTLRTSDGLVTHAALGEDNSDLLAVTYDSASRLRLYRVSIVWNASQQSRGPGVNILRVEPTLDVHHLTAVNNVRPQQIDAAKLTHLRIIPQVAETAQQVPTLPNILAIFTHAAFPAHASPDQSSTSVIARWSVETFAPTLHESFTKLKPGSNTNQVLNQITVLKRQPDIPTNGKVILTFESQMFDTILAFANSDGSLDLRDRVTMEPLGPFGSTDTVSNLHQSGFDHVPGEHNLHIAMSGDGSGLVYVRVDKKVEAQCMKLTRGWHIVDDGISDDRPYIEAAAVCIARQFAFLCYNNIANDETLALLPPDASPELRSLVVKMIFRMLNRSPDISMHENGRQQMIVLKEPLVPRCLSAQLALGTNPMTGERNFAAQYALTILNLRLAGTALASTCGRADVKQISPEAVHFVRGIVRWCMDLIVYIVNTIVTIKRDVQAGSSAKEVIDKLASTSGNPALHVLLCSFSRALVRFQTIWVVKYLQCLQHVVPRTRSVIERQEMEAIFSLAGQLPFKLQQFEGMVAELDQAVRQALFTKSNVSLDRRGELEINMMVDGTIPPELEPAVNSLLENTIPKLTENMDLGKLHFYDTSFLQLANSKRPKNGRILDVLRKVQVPPDAALRVCRRCGAEMEDIAPEKLRQEPFAGWFQHAQRHCVCMNYWLVV
Length899
PositionTail
OrganismPseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.06
Grand average of hydropathy-0.106
Instability index44.21
Isoelectric point6.38
Molecular weight99378.77
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31889
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.06|      39|     113|     422|     461|       1
---------------------------------------------------------------------------
  422-  461 (62.49/38.84)	DTILAFANSDGSLDLRDRVTMEPLGPFGSTDTVSnLHQSG
  538-  576 (67.58/38.02)	DETLALLPPDASPELRSLVVKMIFRMLNRSPDIS.MHENG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.81|      17|      97|     186|     202|       2
---------------------------------------------------------------------------
  186-  202 (31.77/21.62)	WDATI....K........LRDQQGLRAHH
  230-  250 (23.50/13.97)	WQSTSvmldT........LRTSDGLVTHA
  279-  303 (23.54/14.02)	WNASQ....QsrgpgvniLRVEPTLDVHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.27|      12|     101|     101|     112|       5
---------------------------------------------------------------------------
  101-  112 (24.94/14.08)	P.EGRK.FVHIQFS
  203-  216 (16.33/ 7.05)	PaEGRHaFLHISRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.24|      56|     570|      22|      81|       6
---------------------------------------------------------------------------
   22-   81 (82.81/66.48)	PVGLDGSIAMPAAPL......PASLVLRIAEMQSRGccTKIAwSNTG..SIAQISPDGTQITfRTMIR
  589-  652 (85.43/50.67)	PRCLSAQLALGTNPMtgernfAAQYALTILNLRLAG..TALA.STCGraDVKQISPEAVHFV.RGIVR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31889 with Med16 domain of Kingdom Fungi
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