<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31885

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKACTTNIHAVENLVQTAYCVYDWAEAAPAASAAERWEHAQNTLATLRRENILCTSIGHAVWIFGHFNADQKDILDNSHSAFSLSQEGTLENQPAHAPSGRAVRDILLEAIEHALAFTLARHPAIVHVGPWLWLYHSVCDHGDDDDDDDDEDEHALQQVSETSIIHVYTKFTPSGGLYLIPNIMPSSAQPLPIAPRCDPQHVVLAPFGTVATILPDFHDESVLSDDAWKTGLAKALEPHGIVLPAGTLWIAVELENAETTACIWPAALCFTPYRLQHVQDHTTNADRDWRRWFISTEEGTIFRNPLGMAEEWFKGAAERARSGVNLVDTQATLQTDDRPLTELIPTNTAANDPTTMTSPPFSQRAVDQQAAMAGIYPTPPDGYAPMPNASQLNSTTPSATQPEQIANSVDLPPTSDDMQYKSEDSHHVEPNTFGNEDQDMLFGDEDEMEDIGDADFSFFDDHDNDPAIISMRGAELDHSLKYEHDPGDPNSGTNIDDPPIEDDQPSLGIDPTKDTTQTDTIEEVPIEPAEHMQEEASQSPVVVSIPQFGHSVAEPEKPLSPFGIRERLLPPPVPASFTQTDAVGQSDHRRSSTFAPINFREGLNLSRKYSMVTAAPEKEPLKPGTISTSDIGLPNARKKNRIDGNDSSDSDTDDESEGNSYEPSSSDMDDTDLPPRLPWESRKRKRHADQDNLHPLSGSLQRMWSDDEADDRGAGLGMQTPIADVLAAYVNSTPVVDLLAFLKADSESEIADRPHSSAGPTDSMEALSGPLPRMETFYGFPKEDLIYISQIINEQSVSALQLDATRVGGHEDRVAELPIGIANYIYTTIDRGIETVFPDIDQCDLGKVALTREPLRPPTNPGKAPQGPPRPPQRTDSMLLGPDYFHLPPPYVRLQRSSEIWELLPTCLTFWETLGLGPTNGAKNVRAFCVFPENEDLQRLVAGFMTDLGTAYDNCKLGSHVHHRNVSDTDEHDTFEDGMAPVELNEDASLEGAMKSYATTCAELGKALSNIAHQENDRAIVVYILNPFFGRQAQQHLCACFWILFKAYRDNLPKAQRNQAGSDIFLQCLPISLVASYDTLVVPDARQMAILTREVYDRCPPCGPPSDNTSALPILSAPAVELASAAPKRIGFQLAAEPPTDLLHEGSILHIAYSVSRDGHWMSVCWIDNTGRHQSSTAFCLRGRSLAEVIEDVWECTRDILAARQVLWRIFIVTTDTLEKPVLQCWRSFSAKPRTQAICVTLLAIDTDPVLQLSPPVANVDGQFESRSDGGFLTPASTPQAGTFTSSPDVNGQGGNAPPTPAPSETAASAVENDPDAHLTDLTDETWGVLLSPKLNNVGCNVGLANGALFKRVDVAVPDGEGTAADKLPSIGVSIHWTIQVKPSGGVDEGSVKQAELTLREVLRMYRNLALLTKARAIAHGKTSFVPIHVAAAVRGAEGLDGMLGSSEDM
Length1453
PositionKinase
OrganismPseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.07
Grand average of hydropathy-0.379
Instability index46.44
Isoelectric point4.60
Molecular weight158699.92
Publications
PubMed=23236275

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31885
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.81|      14|      15|     437|     450|       2
---------------------------------------------------------------------------
  415-  428 (23.54/14.13)	PPTSDDMQYKSEDS
  437-  450 (25.33/15.87)	GNEDQDMLFGDEDE
  455-  467 (22.94/13.54)	GDADFS.FFDDHDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     406.35|     154|     193|     528|     707|       3
---------------------------------------------------------------------------
  528-  599 (32.01/32.18)	......................................................................................................................................PIepAEHMQEEASQSPvVVSIPQFGHSVAEPE...KPLSPFGIRERL..LPPPVPasftqtdavgqsdhrRSSTFAP
  600-  782 (238.92/121.75)	INFREGLNLSRKYSMVTAAPEKeplkpgtISTSDIGLPNaRKKNRID.GNDSSDSDTDDESEGN...SYE...PSSSDMDDTDLPPRLPWESRKRKRHADQDNLHPLSGSLQR...MWsddeaddrgaglgmqtPI..ADVLAAYVNSTP.VVDLLAFLKADSESEiadRPHSSAGPTDSMeaLSGPLP...............RMETFYG
  795-  904 (135.43/54.96)	INEQSVSALQLDATRVGGHEDR.......VAELPIGIAN.YIYTTIDrGIETVFPDIDQCDLGKvalTREplrPPTNPGKAPQGPPRPPQRTDSMLLGPDYFHLPPPYVRLQRsseIW.............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.68|      39|      59|    1144|    1183|       4
---------------------------------------------------------------------------
 1144- 1183 (68.98/54.06)	DLLHEGSILHIAYSVSRDGHWMSV..CWIDNTGRHQsSTAFC
 1202- 1242 (64.70/45.45)	DILAARQVLWRIFIVTTDTLEKPVlqCWRSFSAKPR.TQAIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     203.39|      62|      73|      38|     103|       5
---------------------------------------------------------------------------
   38-  103 (101.25/86.30)	ERWEHAqntLA.TLRRENILcTSIGHAVWIF....GHFNADQKDILDNSHSAFSLSQEGTLENQPAHAPSG
  112-  178 (102.14/72.46)	EAIEHA...LAfTLARHPAI.VHVGPWLWLYhsvcDHGDDDDDDDDEDEHALQQVSETSIIHVYTKFTPSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.01|      44|      60|     217|     260|       6
---------------------------------------------------------------------------
  179-  203 (34.17/13.05)	.................GL..YLIPNIMPS..SAQPLPIAPRCDPQ
  217-  260 (76.03/37.31)	LPDFHDESVLSDDAWKTGLAKALEPHGIVL..PAGTLWIAVELENA
  278-  310 (41.81/17.47)	LQHVQDHTTNADRDWRRWFISTEE..GTIFrnPLG...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.61|      34|     194|    1103|    1137|       7
---------------------------------------------------------------------------
 1103- 1137 (56.15/32.36)	PPCGPPSDnTSALPILSAPAVELASAAPKRIGFQL
 1301- 1334 (60.46/31.07)	PPTPAPSE.TAASAVENDPDAHLTDLTDETWGVLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.75|      27|     893|     355|     400|       8
---------------------------------------------------------------------------
  355-  384 (48.77/41.85)	DPTTMTSPP.......FSQR........AVDQQaamAGIYPTPPD
 1251- 1292 (35.98/ 7.09)	DPVLQLSPPvanvdgqFESRsdggfltpASTPQ...AGTFTSSPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31885 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSRKYSMVTAAPEKEPLKPGTISTSDIGLPNARKKNRIDGNDSSDSDTDDESEGNSYEPSSSDMDDTDLPPRLPWESRKRKRHADQDNLHPLSGSLQRMWSDDEADDRGAGLGM
2) PASTPQAGTFTSSPDVNGQGGNAPPTPAPSETAASAVENDPDAHL
3) VALTREPLRPPTNPGKAPQGPPRPPQRTDSMLL
4) VNLVDTQATLQTDDRPLTELIPTNTAANDPTTMTSPPFSQRAVDQQAAMAGIYPTPPDGYAPMPNASQLNSTTPSATQPEQIANSVDLPPTSDDMQYKSEDSHHVEPNTFGNEDQDMLFGDEDEMEDIGDADFSFFDDHDNDPAIISMRGAELDHSLKYEHDPGDPNSGTNIDDPPIEDDQPSLGIDPTKDTTQTDTIEEVPIEPAEHMQEEASQSPVVVSIPQFGHSVAEPEKPLSPFGIRERLLPPPVPASFTQTDAVGQSDHRRSSTFAPINFR
608
1278
851
327
721
1322
883
603










Molecular Recognition Features






MoRF SequenceStartStop




1) AIISMRGAELD
2) FGIRERLL
3) MLFGDEDEMEDIGDADFSFF
470
565
443
480
572
462