<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31883

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSNSDSERSPKRQRLNSYSPASTGYPSPKRQRAEQPFIQTPPPSVRMSPSWQSQSQHIPHQSGGSNFPSPPSTAGYQNRMAEGGGDSGRQTPASQDDGELRRDGDGDAVMRDQREGTAADINMTDPEHRRSDHERLGGSTDVDPLPRFKVFAAPIPPSRPHPSQDLIELYGLKCIQANVRRRDPVTGAKINTMRKSYANKLKTLGLEGRNKAVPNQGELSGLLDPGWSQEVQPGSGVTLWDNNWSERGKLGDSNAEADVISKLDAALKMEPGQLPSKERESWNNVLGLDDFSVPSKGSAAATAKTPLASNPALAKTSAAHAMSSSAPASPRNQIRPDRKGKKRSYDDSSFEGYNQGYEDDGYSTGGLDDTGRRRDSSKRQKRKDIPSQANSPAFNPPGAVGVRSS
Length405
PositionHead
OrganismPseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.05
Grand average of hydropathy-1.068
Instability index69.28
Isoelectric point9.31
Molecular weight43873.63
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31883
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.09|      14|      16|     213|     228|       1
---------------------------------------------------------------------------
  213-  228 (19.66/19.66)	V.PNQGeLSgLLDPGWS
  231-  245 (25.43/13.93)	VqPGSG.VT.LWDNNWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.09|      17|      20|       9|      27|       2
---------------------------------------------------------------------------
   10-   26 (31.66/13.24)	PKRQR.....LNSYSPASTGYP
   28-   49 (26.43/ 8.20)	PKRQRaeqpfIQTPPPSVRMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      15|      18|     112|     129|       3
---------------------------------------------------------------------------
  112-  129 (23.55/21.19)	D.QREGTAADInmtDPEHR
  132-  147 (23.60/12.35)	DhERLGGSTDV...DPLPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.34|      38|      78|     287|     324|       4
---------------------------------------------------------------------------
  287-  324 (63.60/32.22)	GLDDFSVPSKGSAAATAK.TP.LASNPALAKTSAAHAMSS
  366-  405 (58.74/29.24)	GLDDTGRRRDSSKRQKRKdIPsQANSPAFNPPGAVGVRSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.47|      11|      21|     246|     256|       6
---------------------------------------------------------------------------
  246-  256 (18.61/10.93)	ERGKLGDSNAE
  270-  280 (19.86/12.18)	EPGQLPSKERE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31883 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISKLDAALKMEPGQLPSKERESWNNVLGLDDF
2) MSNSDSERSPKRQRLNSYSPASTGYPSPKRQRAEQPFIQTPPPSVRMSPSWQSQSQHIPHQSGGSNFPSPPSTAGYQNRMAEGGGDSGRQTPASQDDGELRRDGDGDAVMRDQREGTAADINMTDPEHRRSDHERLGGSTDVDPLPRFKVFAAPIPPSRPHPSQDLI
3) VPSKGSAAATAKTPLASNPALAKTSAAHAMSSSAPASPRNQIRPDRKGKKRSYDDSSFEGYNQGYEDDGYSTGGLDDTGRRRDSSKRQKRKDIPSQANSPAFNPPGAVGVRSS
260
1
293
291
167
405










Molecular Recognition Features






MoRF SequenceStartStop




1) PLPRFKVFAAPI
2) YSPASTGYPSPKRQRAEQPFIQTP
144
18
155
41