<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31882

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFLKGCTTNVHAVDNVVGTSYAQYSWRDDQVGVAERLSHVRATVTHLRERNVLCTCTAEDIWVFGQLGDVDKHRLNAVHEALVVAETGTLQNEPANALSSTRTTKDLFLDAIEHAIAYKLARHPNFVHVGPWTWLYTQTELDDDFGTESSVISISTKWSDSGSLYLVPRLFPSSWQPLKDAVADGATSLILAPMGCLARTVLHDAETTTSSGAWNDQVLAALTPENIHLSAGCDWQTVEIVDDSSETVFAWPSHLCLTHRASKAYYSHAFDGKANWRSWFAGAAVHSTFMNPFALAESWFNGASERQRLALHPGSPATQMEELDELPVSSAPADSADANNMSSPFNQGQFDRQTAMTGIYPTPPDGLAQGLANVQTNLATTPSVTNAENVANTNDLVPTNDDLTREAEQPAAADHDDYQMGPEDLFGDVGEIGFGENDVGDADFSFFDEPDDDTMAADEADVTFAAGTQPERLLDHDAVATGETTMVACSSPDILSYDQRLATDTLQSLVDVTDGSLVPVTEEAPQTPVTCPFRGPYEKPLSPFGIRERLLPPPVPASMAQMDGKREGQQRRNSTFQPVDFRTGFDLSSKYALAGAHDGKKHSDSAGPKAPSIGLPFTRKKSRVSGIDRDASGLNAEDDIESEDDSFESSSSESDDELPPRLPWNSRKRKRATSANATNADLGTEMIRLEDFPYDTFSDGQANQTLSSILESRTVGPNSMNLVSTLRIPLDEAQAQRRDLHDGRTSQVNEDILPSMAEGYDFSKDDLICVAQIVSEHSATAFRDVNSAQDEPALCMNGSLKRSVETVLGETLPDSNIHDLGQVALNREPPPRAMPNNGKGPQGQPRPPQRSESTMIGPDFFPLPAPYVKVQRGSDGFEMLPTSLPFWEPLGLAPTSGSKDVQAFCLFPDNADLQRAVRRFMHDIGTAYEGCKHGSHMHVRTGDAKIEIDSYEDGLAPVTLDDDISIFGAFKAYAVTCAQLGKVLASIGHHESERAIVIYMLNPFAGHQALHHLCACFWVLFKTYRENLSKAQRNHSGSDVVLQIVPIHLVASVNTMVVLTSKQAMTIAREVYDRCPPSATLLAGGDSAALPILSAPSIELASAAPKRIGFQLAAEPPSHLLHEGSVLHLAYACSKDWQWVTAAWGDNTGLYQSSVTYSLRGKSLAEVAEEVWERTYEILAARKVTWRLFIVTHQGLDQSMSQCWRSLSKPRAQPLCVTLSSVQLDPVLVADSPASPEAQLKDNSQDGGFLTPASTPQGNNFTSSPDVSGQSNAPATPAPSDTPASALEMETETHLVDVTDETWGVLISPNFSSLIVDVGLANALIFKRGEAAAASSDGSRRSLPGMGVTLHWTIQVKPNGAIDEGSVKQAELTLRELVKMYRNLALLTKAKGLDRGKAVCAPLPVAAAMLGAEGLDGFLPAIQR
Length1425
PositionKinase
OrganismDothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Dothistroma.
Aromaticity0.07
Grand average of hydropathy-0.312
Instability index42.80
Isoelectric point4.82
Molecular weight154308.33
Publications
PubMed=23209441
PubMed=23236275

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31882
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.87|      19|      19|     386|     404|       1
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  369-  386 (21.79/11.58)	.AQG..LANVQTNLATTPSVT
  387-  405 (31.33/20.83)	NAEN..VANTNDLVPTNDDLT
  407-  426 (20.75/10.57)	EAEQpaAADHDDYQMGPEDL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.47|      18|      19|     464|     482|       2
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  464-  482 (27.20/20.75)	TFAAGTQPErLLDHDA.VAT
  486-  504 (28.27/16.28)	TMVACSSPD.ILSYDQrLAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.39|      27|      35|      16|      42|       3
---------------------------------------------------------------------------
   16-   42 (48.78/33.04)	NVVGTSYAQYSWRDDQVGVAE..RLSHVR
   52-   80 (45.61/30.38)	NVLCTCTAEDIWVFGQLGDVDkhRLNAVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     526.42|     175|     899|     170|     366|       4
---------------------------------------------------------------------------
  176-  364 (290.70/243.51)	WQPLKDAVADGA...TSLILAPMGC.LARTV...LHDAeTTTSSGAWNDQvlaaltpeNIHLSAGcDWQtVEIvdDSSETVFAwPSHL...CLTHRASKAY.YSHAFDGK..ANWRSWFAGAAVHSTFMNPFALAESWFNGASERQ.RLALH.........PGSPATQMEELDELP............VSSAPADSAD.ANNM....SSP...FNQGQ...FDR.QTAMTG..IYPTP
  590-  706 (70.47/33.18)	.................................................................................................SKYA.LAGAHDGK..KHSDS..AGPKAPSIGL.PFTRKKSRVSGI.DRD.ASGLNaeddiesedDSFESSSSESDDELPprlpwnsrkrkrATSANATNADlGTEMirleDFPydtFSDGQ...AN..QT...........
  798-  865 (35.59/ 6.16)	...........................................................................................................................................NGSLKRSvETVLG.........ETLPDSNIHDLGQVA............LNREPPPRAM.PNNG....KGP.....QGQprpPQRsESTMIGpdFFPLP
  888- 1006 (129.65/75.42)	WEPLGLAPTSGSkdvQAFCLFPDNAdLQRAVrrfMHDI.GTAYEGCKHGS........HMHVRTG.DAK.IEI..DSYEDGLA.PVTLdddISIFGAFKAYaVTCAQLGKvlASIGHHESERAIVIYMLNPFA.........................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.16|      43|     172|    1078|    1121|       5
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 1078- 1121 (67.89/35.21)	PSATlLAGGDSAALPILSAPSIELASAAPKRI.GFQLAAEPPSHL
 1253- 1296 (71.27/33.77)	PAST.PQGNNFTSSPDVSGQSNAPATPAPSDTpASALEMETETHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.69|      37|     184|    1008|    1052|       6
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 1008- 1052 (52.80/54.66)	HQALHH.LCACFWVLFKTYRENLSKAQrnhsgSDVvlQIVPIhLVA
 1194- 1231 (63.88/40.02)	HQGLDQsMSQCWRSLSKPRAQPLCVTL.....SSV..QLDPV.LVA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31882 with Med13 domain of Kingdom Fungi
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