<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31878

Description Mediator of RNA polymerase II transcription subunit 7 (Fragment)
SequenceFPAPPPFYGHFTKFNIARLRQLRREVGIPAPAPTDTILDATAANDADIDILSLPVELRYLIPPAPPSDGKYTAFGNTIDPHAAERSLAERDIEQLYPSNTSSRLNPQPHLTALTRSMLTTFLALSGILSQNPELYEEKVKDLHTIAMNIHELINQYRPHQARETLIMMMEERVDKMKKESHDVDKAKEKVAKLLQDIHD
Length199
PositionMiddle
OrganismDothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight fungus) (Mycosphaerella pini)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Dothistroma.
Aromaticity0.06
Grand average of hydropathy-0.475
Instability index55.38
Isoelectric point5.91
Molecular weight22514.45
Publications
PubMed=23209441
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31878
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.00|      20|      23|     144|     163|       1
---------------------------------------------------------------------------
  144-  163 (35.81/20.86)	TIAMNIHELINQYR..PH...QARE
  164-  188 (24.19/12.38)	TLIMMMEERVDKMKkeSHdvdKAKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.69|      13|      58|       2|      14|       2
---------------------------------------------------------------------------
    2-   14 (29.08/14.75)	PAPPPFYG..HFTKF
   29-   43 (19.05/ 7.57)	PAPAPTDTilDATAA
   63-   74 (25.56/12.24)	PAPPS.DG..KYTAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.31|      10|      23|     101|     110|       3
---------------------------------------------------------------------------
  101-  110 (18.93/12.40)	SSRLNPQPHL
  125-  134 (17.38/10.84)	SGILSQNPEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31878 with Med7 domain of Kingdom Fungi
Unable to open file!