<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31864

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYLTNVISHLTELSQNNLTSISYEYFVPLFPVSNILKIKLQNLELLWRKTGKLVYYDHVRVQIWVFLSSPSTQECELQYSDSSTSSSTQNLDEIGEFGHLHKKSGTYEPATLAMNASMSSINSPINSLSSTSLESPSKNLQASSSRTSLASLTIHSPRKILSRISETKGTEVNSDNVSREEIHQYFISAVLESMMYFLCRDGGFIPFNSRTLISTIRQPIPCLENSNMVEFTTLDISLTSMGTIMLKAHFNVAQRLRGIKNLLKDSNEPDQLQSGDHLWLAPCGNSAKYYGTLACDNVETFGLVLDGKRHILDTISKNIVKVWQVRFLEWLKYRGMDSIAIESGGWVLIQILTGHSPYANIELEKIPILVDSGAVPWPLILCFRNLTQDKTGNLNKSLDAVQCYDPIKFAEEWYSSQERVKIVNQRQKERHGAEVSSKERTNPELPTSRYHKKSMEAVRKESSTGNIYPTPPDALLPPTVITPSLEETECTPENANSCAPIEPDDVGPNINNETHFSSESWVSASKKDQNPSINFSENFSENDIIFTDHGGDMFGTDITDADFNFFDEPDIEIEHTNKQTPISNFQATIKEMGETQTSENAVAEDRQLTISDKNTVQAVIYNEAQENINSDKSESLQEKPLNLLVATASQISQSQPSTSANLQHVNARSPFSKEIIFNRLKIEQLPIRSESLRRLSIFDRIDFEPSILSINKKYGPSGRYNIIPEVRKPSILEPSSLPRLDVLARKKNIRVEHKHIETDQDPWVKFYKEITNASVSQETKDNSTDLDHRATTPEEDGSISNTEPEIFFGTSKKRKWEETEGDTISPSENIIRGYAQAASPQSINDPTVFLFEPYQVGWPHESHFILPEPTARSDELTDIELIETTQILADQALSGRFQLPGVPKHDFFPDFQNRISVKKKLHCITAAAQKIFCNATICTLRDFLDVQGIPISNQVLRLPPRPNTNQKGFPGTNVRSNDLFPIDSPHLEVRRADAGISVLPSAIGFWEIFGLGPFSGVKNVRAVCVHPNFDGLAASSNTLLDRMRGFYESARFGSHDRIISPDIDNGLIPFTIKTSQPNYSRLSALKEMTENLSRTLSRLTIQNINLVVYFVYPPNDGDLLVQICAAFHHLFSMYRKSLIESKVAPVNEIVLQLIPLDFIASPTSLAVPRPSEYFGLALEVYDRCINFESSTMPAITLEPPLLKSIDFKLTSNPSPSLLHENSCLHIAYAKSIDNRWITAAWIDNRGIQQMTASYCLGRKNKTITTTFAEVANEIWETTLDFISDQKIQWRLIIARVGIMDLSETEFWTGLAAAETNAKISLTLVTVKTNVSLEIIPSCISLLSNEAMGIKKSAPIFKIQGSQSSCGIPENTTTTVDAASEPDLNARLIDLTDQTWGAVLSHRVNNSNSLEELNLALVSGYLFKRGGTNPEDPPVPMEVNVIFSEVNGNPRTFHENLLKEILGYYRCLGTLARVRRVVDVNKDIRPWHIAAVEKAVEALYMLM
Length1506
PositionKinase
OrganismBlumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Erysiphales> Erysiphaceae> Blumeria.
Aromaticity0.08
Grand average of hydropathy-0.319
Instability index48.34
Isoelectric point5.43
Molecular weight168766.91
Publications
PubMed=21148392

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31864
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.53|      33|     454|     686|     742|       1
---------------------------------------------------------------------------
  400-  432 (57.90/25.73)	KSLDAVQCYDPIKFA......EEWYSSQERVKIVNQRQK
  694-  732 (50.64/49.48)	ESLRRLSIFDRIDFEpsilsiNKKYGPSGRYNIIPEVRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     600.37|     190|     299|     927|    1121|       2
---------------------------------------------------------------------------
  927- 1121 (320.25/221.35)	CITAAAQKIFCNATICTlrDFLDVQGIPISNQVLRLPPRPNTNQKGFP..GTNVRSNDLFPIDSPHLEVRRADAGISVLP.SAIGFWEIFGLGPFSGVKNVRAVCVHPNFD.GLAASSNTLL.DRMRGFYESAR.F...GSHDriiSPDIDNGLIPFTIKTSQPNY.SRLSALKEMTEN..LS.RTLSRLTIQNINLVVYFVYPPNDG
 1227- 1429 (280.13/181.56)	CLHIAYAKSIDNRWITA..AWIDNRGIQQMTASYCLGRKNKTITTTFAevANEIWETTLDFISDQKIQWRLIIARVGIMDlSETEFWTGLAAAETNAKISLTLVTVKTNVSlEIIPSCISLLsNEAMGIKKSAPiFkiqGSQS...SCGIPENTTTTVDAASEPDLnARLIDLTDQTWGavLShRVNNSNSLEELNLALVSGYLFKRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.48|      32|      47|     508|     539|       3
---------------------------------------------------------------------------
  508-  539 (57.48/33.25)	DDVGPNINN.ETHFSSESWVSASKKD.QNPSINF
  556-  589 (50.00/27.96)	DMFGTDITDaDFNFFDEPDIEIEHTNkQTPISNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.11|      18|      23|     120|     142|       4
---------------------------------------------------------------------------
  120-  142 (24.93/25.39)	ASMSSinspiNSLSSTSLESPSK
  146-  163 (31.18/17.72)	ASSSR.....TSLASLTIHSPRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.06|      22|      23|     792|     813|       5
---------------------------------------------------------------------------
  792-  813 (40.07/24.17)	HRATTPEEDG.SISNTEPEIFFG
  816-  837 (30.08/16.12)	KKRKWEETEGdTISPSE.NIIRG
  839-  854 (20.90/ 8.73)	AQAASPQ....SIN..DPTVFL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31864 with Med13 domain of Kingdom Fungi
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