<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31860

Description RNA polymerase II mediator complex
SequenceMSGTNRKLSTVNPQSDKPTTAATSDVAVHEWKHLNLTPLKISSDHDLLAQDNPSFHHTLTNNQSCKSIPMPARPGKNRSQVSKCRNPTTSSLKRDTRPKPYVLEVPNDAPRLSSNTYSDFFPWVGNNPEDQFSETIIRQGYYDKCQSAQIEIGSARSTVFPALKHKSGLQTLSSTITSILLQRRSHSQIVSTSTFKPPPRVTVTDTKREMWLKDLANPSVSLRRLSRSIPHGVRGKVLLEQALAKFIPIERTVWLARCVGANELRSFRRKGVSGTLSMGGETKWIRDFTICVEQFLESIMGSCSVNDFKLKIDYAIRLATHFYDESLLDRDHYMEWIISSLENTTQTKLPLWLLIIQIYWKDLSRYRKYGCRLSFGLLYHLSEISSSSDIDLLAPLSERVINLIKDQMIWNRNNFVAPKAWAQYRDLAYSNVVMGEKQIIPFYDTIDSRNSRLVTSYKTKTSSPQQNLLKLLDKTLSGLYNNKTASEAWSLCDDKILLTQTIINWSTSSCRPGKTKIYVAARILRTWYKFNIDITEIILSFLELECCESGRNKADFYHLISELARSGHFHTPSYVQWIIARGGVQSSQALDLDGPCATRLLVELPMSNQSKPILDMRLMLMSRANYSTQEEIHSVRKCKSLLCRRLSKVQNDVSLKSDDSKDLPEDIRRLLSSTSRTVKSEIGLWLRDQVIQTMRLTETLLKGSEDPNIGFKAPTITSSEFDIICQSLEDLEDISMLADVLKIVSTCNDINILTLCAGTLNLHCENFAAIGALLEIFEALLSRSREIRELSNFFPVSFLEALLELGSRIESQDIIIEELNQELSRNYNKPRIDACSPISDCHAIQEPTDPNIIEEIEKVITYGTNFDLKALEKLFWKTTAILESSWENLLEKQRTCGMILTKIRTHEARQFDSLMAKWLERIIDLPCRPNLIQICAPLVCSGCLTLHIVLSNCEDKFNETYSKKQSDVNDLNLEVLDLIFSCPKSLEALNPEEANRYRIKQMDLLRNSLTDAICALRLAFEIFQPGSRTSHNIYQSGLNYFKNKNMQQLLQNLVLFETDIFVHELLIPLLNSSNSDAKAAINKAIDLVLNPSSLYVKINADALLNIVDDLSMQFCRVKLIIMFGASKVGQDLDENLSNLESFCIAIESAIFIGNRNWANLVPLLDINPAQYLRYRAETKFISLVPSLKNIGEFNFSTHERQVSICKDLLLVISAATCSPSAAPAQHNDDSLLICEISEVLNGLWLILSSSQTQDVKDFIIEKWIPLLLSFISAHTPILEAINLTESKAKIVLTLVSIIYHLQIFDTNQEGIEPLVENCYDLAIQIADYLPDDVRQQCFKNLHDGIYTLQLSYLFNYTSGDNENLVLSQNNSKTADQSAETCDKDWSDKEQLKSFYIRRWEMLGEPTPNMFENDTSLSLTLFGARRS
Length1426
PositionKinase
OrganismBlumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Erysiphales> Erysiphaceae> Blumeria.
Aromaticity0.08
Grand average of hydropathy-0.207
Instability index46.68
Isoelectric point6.13
Molecular weight161937.65
Publications
PubMed=21148392

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31860
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.90|      40|     343|     306|     357|       1
---------------------------------------------------------------------------
  306-  357 (57.96/64.02)	NDFKLKIDYAirlathfydeSLLDRDhyMEWIISSLENTTQTKLPLWL..LIIQ
  651-  692 (62.94/39.60)	NDVSLKSDDS..........KDLPED..IRRLLSSTSRTVKSEIGLWLrdQVIQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.29|      40|     344|     898|     950|       2
---------------------------------------------------------------------------
  712-  763 (62.40/31.04)	KAPTITSSEFDiicqsledlediSMLADVL.KIVS.TC..NDINILT..LCAGTLNLH
  902-  947 (58.89/53.50)	KIRTHEARQFD............SLMAKWLeRIIDlPCrpNLIQICAplVCSGCLTLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.43|      14|     341|      36|      49|       3
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   36-   49 (25.07/13.37)	LTPLKISSDHDLLA
  381-  394 (23.37/11.97)	LSEISSSSDIDLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.25|      29|      35|     959|     991|       7
---------------------------------------------------------------------------
  969- 1004 (40.90/40.26)	NDLNlevlDLIFSCPKSLEALNPeeaNRYRIKQMDL
 1007- 1038 (44.34/32.42)	NSLT....DAICALRLAFEIFQPgsrTSHNIYQSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.93|      16|     566|     625|     642|      13
---------------------------------------------------------------------------
  625-  642 (25.41/21.07)	NYSTQEEIHSVrkCKSLL
 1194- 1209 (30.52/18.44)	NFSTHERQVSI..CKDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.91|      23|     893|     483|     505|      14
---------------------------------------------------------------------------
  483-  505 (42.87/26.95)	KTASEAWSLCD....DKILLTQTII.NW
 1372- 1399 (33.04/19.05)	KTADQSAETCDkdwsDKEQLKSFYIrRW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31860 with Med12 domain of Kingdom Fungi
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