<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31857

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMQLSLQIEAWRNFFERCLSNRLEPNDFTTFATILHQQHPLPSFYLCTLFLSPTPGNNICLDPKASRYVFCLLSLGFVDIPNILRALWRSSTCRAINCEQLNEDQENSWARSFNAEETIFYRLTKIISSGLALKTVKEAVETVELCIQWLEGTITLAQAQHQLQALLNVQSDEVTAQIMATAIAKGHICKTSRKRLGKVVSNFITLMLLHWPQGVDRLEAFRTETLPAIEPVEKASKSGVDKDIEDIIGEGISGAISVNNMVVSEMDEVNTRVGLYIFLSSLLVGRPLIDDNAIFKYLNNRYQGDLRSTVVDLILAAFDVLANAMVRNEKDQTKNLLRCFLINKLPHLLSTLCTQLFPPITSEICITEALSQVDTTNFPTLSAMFDETSGNNMFPESVRQDFCFACCLHGLIAESSIETLLGDVPIQSLPAEGRYLKNELVQKCLSESDRVERMIDELEYMDGNVGANSQAITELITRLCNNKETMALKSICDKLVRNPSSLDIMLLFDKPISILQPICDLLDNWHYDEDQGEYQPVYEEFGSILLLLLSFVKRYDLTPLSLGPRSSDSFVLKIIQVPRTTSHSSLSQTTQSHLKSWLLGLFSPENSGLTDDLMSSCPPQDFYLLIPFLFSSIVLASSTYGLVSTTLSSGLEYLVDTFLLPSLVPGISFLATHLWENHGDKDAVVQILSSLIITPLSNTNNINSEALEHSLRWLQRAEPQRQDIEPLSKALRCYLGWERCAVSQHTELENWTSTNGGGLLMAIKQTITNLLQWHLQPDANPANYTHRQILVGVKILGAKRVIKIIVEELKSGIEAGHGGAALDIASALVSSSDATAWDSTFGLGSAVGNNEETRYLQRRMNLREALKNEAYNAPKLQRTDPFTAETIVRLYRKVESLVVNGNIEGHEVLTAAELNAVVDMSGLAQTDGTHDDISGLENIATISGLDMGHMVNFDGLDDGFAETGVNLMIEGDFMRSEERQGTLLEGMEF
Length988
PositionTail
OrganismBlumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Erysiphales> Erysiphaceae> Blumeria.
Aromaticity0.07
Grand average of hydropathy-0.039
Instability index45.86
Isoelectric point4.88
Molecular weight109957.26
Publications
PubMed=21148392

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31857
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.07|      22|      25|     703|     724|       1
---------------------------------------------------------------------------
  703-  724 (39.15/22.88)	SEALEHSLRWLQRAEPQRQDIE
  727-  748 (40.93/24.22)	SKALRCYLGWERCAVSQHTELE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.47|      17|      25|     478|     494|       2
---------------------------------------------------------------------------
  478-  494 (30.83/19.36)	LCNNKETMALKSICDKL
  505-  521 (30.64/19.19)	LLFDKPISILQPICDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.83|      22|     574|     376|     401|       3
---------------------------------------------------------------------------
  376-  401 (34.53/32.61)	NFPTLSAMFDETsGNNMFPESvrqDF
  951-  972 (42.30/25.84)	NFDGLDDGFAET.GVNLMIEG...DF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.27|      50|     575|      34|      87|       4
---------------------------------------------------------------------------
   34-   87 (88.98/70.54)	LHQQHPLPSFYLCTLFLSptpgNNICLDPKASRYVFCLLSLG...FVD..........IPNILRALW
  612-  674 (76.28/49.78)	LMSSCPPQDFYLLIPFLF....SSIVLASSTYGLVSTTLSSGleyLVDtfllpslvpgISFLATHLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.77|      18|      19|     840|     857|      10
---------------------------------------------------------------------------
  840-  857 (31.09/23.17)	FGLGSAVGNNE.ETRYLQR
  859-  877 (25.68/17.71)	MNLREALKNEAyNAPKLQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31857 with Med5 domain of Kingdom Fungi
Unable to open file!