<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31849

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMFIVANQSNPWRRKAYNYELPVVLCGCPQLAVFTSLASSALYHPVTATVYTKRFMILMEDRVASTVDTEDGTDSASKKSSIPVMANNNHTSHVQNNAGLHTSDFKTSNNHQNPYNRPNQFPSEISHITHGYLSLQKLIARLAQKTHSDLLGTIKDLAQLPLPTSKLSSNGSTVTMADDNSVENLTKKLRVLKFATDAHEAWTKALVITGWSRKADDVSKIIDLKVHLDQKQNEYVAAIEQMAHDKKGYIHARLPNPDIKTALEVLVTGKVSWMPEFGYITPPPLTSQEILRTLEQLNTLLAIRLNLDEYNTVPYHFKNFHIRSGRVTFTVAGEFELDLTIAEEAPQAQYWFLDLRFKFSPSLKVIDNSLRYFLESRINSILLQDGLNGCYNFLHDLTLTYKIGEFRRQAIYLARYRWVHSAKVEALNRSTCIQYWIDRFHRAPKTIKAPKSWLILGVHSGKSKNGRPNLKATRKLGIRWFRDNKEQKDVEISIDDVNISAEALLTAVVSKHIAYILTSIYQNLKAKPLYAKCDLSLCLSISNSDSAKSNLKVQLTTENYLTIKIEPISGLFVFEPPTRKFLDYQRRLNTLVIDPAARAHEHIELLRYSLLFDNLLGHGWTTGWKNIRNPGVNILEMKRVFTDAAQVLWFRRSGWPENWYLTISMNMAGENWRLVQTTMTIDPTNPNGMMIISTQIKMPIKVVSPVTNYSFMITCSIFSAALISYYENLKTLWSQRIVYTLTPSIKSGPLKLPHIYIKSSEILTSQNVSSSTGNPWAKDAVRLSYHGLESAQPVSKVIGNHTENSTKNSKHVVITKDTAVMVAEIRIMKPIPRPLLISRKLFGKNTAFHSNLGSFAFRLRSYVGESVISSLVQSLDSLELLVECIQVLERHEGALKCESISLERIDLAYRNGPCVESITSLSSNELVYKAAIVLNPKGKKLDLQFRTRNPHIRVADHLNNLLNSSQGLHSIATILPLTIQILCEIENIEDTWAASMRDHGTVIINARAVDWYVIRYKITKYSTMPHASRVTRTFLFDTRLCQRQGEAWWHIRRRGAYVSDDFNPVKKDDLDQLLIPLWQKSGNSWQGMRSSAVAKCEGIAELLQNLDQIIQSFAKNGATWSHGKPQKAQTASMISFPPNRPLAPLVSTSIMMTTAPTATMRAGSQLKQIKPQQNKNLSTQNTNASHGVVQTRNNLIKREIVEID
Length1203
PositionTail
OrganismBlumeria graminis f. sp. hordei (strain DH14) (Barley powdery mildew) (Oidium monilioides f. sp. hordei)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Erysiphales> Erysiphaceae> Blumeria.
Aromaticity0.08
Grand average of hydropathy-0.258
Instability index35.10
Isoelectric point9.49
Molecular weight136124.88
Publications
PubMed=21148392

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.31|      47|     468|     563|     707|       1
---------------------------------------------------------------------------
  609-  658 (79.33/177.82)	LLFDNLLGHGWTTGWKNIRNPGVNILE....MKRVFTDAAQV.LWfRRSGwpENW
 1033- 1084 (78.98/14.25)	FLFDTRLCQRQGEAWWHIRRRGAYVSDdfnpVKKDDLDQLLIpLW.QKSG..NSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     171.28|      53|     690|     234|     290|       5
---------------------------------------------------------------------------
  234-  290 (87.42/56.60)	YVAAIEQMAHDKKGYIHARLPNPDIKTA..LEVLVTgkvSWMPEFGYITPPPLTSQeIL
  927-  981 (83.86/44.29)	YKAAIVLNPKGKKLDLQFRTRNPHIRVAdhLNNLLN...SSQGLHSIATILPLTIQ.IL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.75|      11|      83|     348|     360|       6
---------------------------------------------------------------------------
  348-  360 (16.20/17.70)	QYWfLDlRFKFSP
  433-  443 (25.55/14.86)	QYW.ID.RFHRAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      14|      15|     128|     141|       7
---------------------------------------------------------------------------
  128-  141 (24.05/15.50)	TH.GYLSLQKLIARL
  145-  159 (19.42/11.11)	THsDLLGTIKDLAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.77|      12|      15|     176|     190|      10
---------------------------------------------------------------------------
  176-  188 (15.64/16.28)	ADDnSVENLTKKL
  194-  205 (22.14/ 8.81)	ATD.AHEAWTKAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31849 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PTATMRAGSQLKQIKPQQNKNLSTQNTNASHGVVQT
2) VDTEDGTDSASKKSSIPVMANNNHTSHVQNNAGLHTSDFKTSNNHQNPYNRPNQF
1155
66
1190
120










Molecular Recognition Features






MoRF SequenceStartStop




NANANA