<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31847
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. The Mediator complex, having a compact
conformation in its free form, is recruited to promoters by direct
interactions with regulatory proteins and serves for the assembly of a
functional preinitiation complex with RNA polymerase II and the general
transcription factors. The Mediator complex unfolds to an extended
conformation and partially surrounds RNA polymerase II, specifically
interacting with the unphosphorylated form of the C-terminal domain
(CTD) of RNA polymerase II. The Mediator complex dissociates from the
RNA polymerase II holoenzyme and stays at the promoter when
transcriptional elongation begins.
ECO:0000269 PubMed:11555651
ECO:0000269 PubMed:16076843
ECO:0000269 PubMed:16109375
ECO:0000269 PubMed:16263706
|
GO - Cellular Component | core mediator complex GO:0070847 IDA:SGD
cytosol GO:0005829 IDA:SGD
mediator complex GO:0016592 IEA:InterPro
nucleus GO:0005634 IDA:SGD
|
GO - Biological Function | structural molecule activity GO:0005198 IMP:SGD
transcription coactivator activity GO:0003713 IDA:SGD
|
GO - Biological Process | F:structural molecule activity GO:0005198 IMSGD
negative regulation of transcription by RNA polymerase II GO:0000122 IMSGD
positive regulation of transcription by RNA polymerase II GO:0045944 IMSGD
RNA polymerase II preinitiation complex assembly GO:0051123 IDA:SGD
|
Interaction
Repeat regions
Repeats |
>MDP31847
No repeats found
|