<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31846
Description |
Mediator of RNA polymerase II transcription subunit 9 |
Sequence | MASSGVAGGRQAEDTLQPPPELLPESKPPPPPQPLPVAALPPPAAPRPQSPAGAKEENYSFLPLVHNVIKCMDKDSPDLHQDLNALKTKFQELRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKSLCMFEIPKD |
Length | 142 |
Position | Middle |
Organism | Mus musculus (Mouse) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Glires> Rodentia> Myomorpha> Muroidea> Muridae>
Murinae> Mus> Mus.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.684 |
Instability index | 87.44 |
Isoelectric point | 6.91 |
Molecular weight | 15708.92 |
Publications | PubMed=11997338
PubMed=16141072
PubMed=19468303
PubMed=15489334
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IDA:MGI
nucleoplasm GO:0005654 TAS:Reactome
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31846
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.32| 19| 21| 77| 97| 2
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77- 95 (31.25/19.65) PDLHQDLNALKTKFQELRK
101- 119 (33.08/15.09) PGIHVSPEQQQQQLHSLRE
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|