<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31824
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MASLNQEQLKILEQTRQRLLHLTQSLGSLSNSINQSDPLPPWSSLQSQATIISNNLLSISHLLTEHQELLSSIVAYPTPNFPGRTESTILHQLMRTKLEPRVEEWVARGRNVARHNTASSQIRAQQGAAAEGETVRLSVDELLDLWHWAPIAANMEARRRDWGGDYTLEEKEMGVKNVITGLKRQLDEGDEEDEEEEEEEEDMQGEEMEVVVGAHTKAGGGSGVEFDIARGSSHIPSKPVAPGMPLDDIFRFMMTGAPPRPR |
Length | 262 |
Position | Head |
Organism | Coccidioides immitis (strain RS) (Valley fever fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.597 |
Instability index | 55.83 |
Isoelectric point | 4.89 |
Molecular weight | 29205.31 |
Publications | PubMed=19717792
PubMed=20516208
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31824
No repeats found
|