<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31821
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MSQTPFNPNSPSVPTTTSLPSTDFSQIPYDVLESIRNRLNQIRQSLTKLADQINNHNRHPQKIKLPSYSYFQNQFQVLITQLMSITNQLYNNEDLLRNTNVYPTPIFPTSAHENMLTTLLRKKVAPEVDEWINGAKLIMENETKNKLDNQQVEIDILKIDQWVQWCLAKIQDLRDEFQFYGFHTVEELDHMETPQGKQEIKEKKDKEFEREQIELKITAGGQKSLHPNQVLKFMCQGQI |
Length | 239 |
Position | Head |
Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.723 |
Instability index | 35.02 |
Isoelectric point | 5.90 |
Molecular weight | 27958.39 |
Publications | PubMed=15123810
PubMed=17419877
PubMed=24025428
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31821
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 155.15| 40| 40| 39| 78| 1
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14- 32 (20.03/ 6.76) .....................PTTTSLPSTDFSQIPYDVL
39- 78 (70.00/38.85) LNQIRQSLTKLADQINNHNRHPQKIKLPSYSYFQNQFQVL
82- 119 (65.12/35.72) LMSITNQLYNNEDLLRNTNVYPTPI.FPT.SAHENMLTTL
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