<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31820
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MEYPNPPPPVTSNYQGEPEKIAQATDMMIKRVTDAKKIIEELLQMLDLQEKCPWPLMLEKFSTLASFMSSLQSSVRKSGMPHGHEDYGQFLRSHVLVTQRLQYEPDETLQRATQGRVMSWNHALVPEYLRTKPNPEMENEEGMLDGERSAKSADLVVRQIAAYNKNIEGLINHLNSVDRMHTEAAIEKPTYNRDETAKIVKSILTGEGIRSQRTMAPAPPSSAPMTTAPSSTGPSSSQPISGNQPEYQGSQLRQQLSGGQPQTSQAHLPMYSHHQQPQYSHQQPMNPQHHSPMKFQQ |
Length | 297 |
Position | Head |
Organism | Caenorhabditis elegans |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Rhabditida>
Rhabditina> Rhabditomorpha> Rhabditoidea> Rhabditidae> Peloderinae>
Caenorhabditis.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.836 |
Instability index | 65.16 |
Isoelectric point | 6.46 |
Molecular weight | 33437.30 |
Publications | PubMed=9851916
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA:GO_Central
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31820
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 205.63| 51| 126| 4| 60| 1
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10- 60 (87.57/58.89) VTSNYQG..EP.EKIAQATDMMIKRVTDAKKIIEELLQMLDLQEKCPWPLMLEK
97- 137 (57.49/26.10) VTQRLQY..EPdETLQRATQGRVMSWNHA..LVPEY.....LRTK.PNPEM...
139- 188 (60.57/30.60) ...NEEGmlDG.ERSAKSADLVVRQIAAYNKNIEGLINHLNSVDRMHTEAAIEK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 136.15| 39| 42| 206| 247| 2
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206- 247 (65.47/33.61) GEGIRSQRTMAPAPPSSA..PMTTAPSSTGPSSSQPISgnqPEY
249- 289 (70.67/30.48) GSQLRQQLSGGQPQTSQAhlPMYSHHQQPQYSHQQPMN...PQH
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