<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31813

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMETQPQQPPPPPVAEKLNPKLEKELNLESLKTRAVSLAKAIARILEDFDAYGRTNTTPKWQDILGQYSMVNLELFNIVEEVKRVSNAFVVLPKNVNAMNAAILPVMLSSKLLPEMETDDNAKREQLLQGVQSLPIPMQIERLKARMDMIAAACENAERVLADTRKAYGFGTRQGPSMLPTMDKGQAAKIQEQEKMLRDAVNDGKGTQLPPDQRQITTALPPHLADVLIINDAGKIALPGQSNNINNQGMMQVSGTQFVGRSAASPSGPNFDNTTSPLPYSNSPRATGMVNVPSPQHQIQQQQFQQQQQRSKLMQLPQHQQQQLLAQQQQQLRQSSMQGLGQSQIPALHDMHGQAQQKFQTSHGQHQMPYSQPMGAHQQFQARQLSGGHIQHSMSQGQLNPAMNRHLNQFSGGANSALFTSAQGSPSSQMIPNMSSMQSQTLVPRMQQFGVSGTNPQRSHSSQMLGDQMFNTSGMMQTQQTQIQQSQQQQQQQQQGGYGNMQTNQQSLQPNNMMQNAQQRHQNPQ
Length524
PositionHead
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.04
Grand average of hydropathy-0.782
Instability index58.42
Isoelectric point9.42
Molecular weight58155.95
Publications
PubMed=10617197
PubMed=27862469
PubMed=15342534
PubMed=17560376
PubMed=19671879
PubMed=22021418
PubMed=22223895

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Regulator of both plant defense and flowering time. Involved in pollen tube growth. 
ECO:0000269	PubMed:15342534
ECO:0000269	PubMed:19671879
GO - Cellular Component
mediator complex	GO:0016592	IDA:UniProtKB
GO - Biological Function
GO - Biological Process
defense response to fungus	GO:0050832	IMTAIR
regulation of flower development	GO:0009909	IMTAIR









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31813
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     420.77|     138|     183|     169|     330|       1
---------------------------------------------------------------------------
  129-  186 (39.02/ 8.56)	........................................................................................................................GVQSLPIP.......MQIERLKARMDM..IAAACENAERVL.......ADTRKA......ygFGTRQGPSmLPTMdKGQA
  187-  354 (210.24/96.06)	AKIQEQEKMLrdavNDGKgTQLPPDQRQITTALPPHLADV.......LIINDAGKialPgQSNNINNQGMMQ............VSGTQFvGRSAASP.SGPNFDNTtsplpysnSpratGMVNVPSPQHQIQQ.QQFQQQQQRSKL..MQLPQHQQQQLL.......AQQQQQlrqssmqgLGQSQIPA.LHDM.HGQA
  375-  521 (171.51/54.02)	AHQQFQARQL....SGGH.IQHSMSQGQLNPAMNRHLNQFsggansaLFTSAQGS...P.SSQMIPNMSSMQsqtlvprmqqfgVSGTNP.QRSHSSQmLGDQMFNT........S....GMMQ..TQQTQIQQsQQQQQQQQQGGYgnMQ...TNQQSLQpnnmmqnAQQRHQ..........................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31813 with Med8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTRQGPSMLPTMDKGQAAKIQEQEKMLRDAVNDGKGTQLPPDQRQITTALPPH
2) LPGQSNNINNQGMMQVSGTQFVGRSAASPSGPNFDNTTSPLPYSNSPRATGMVNVPSPQHQIQQQQFQQQQQRSKLMQLPQHQQQQLLAQQQQQLRQSSMQGLGQSQIPALHDMHGQAQQKFQTSHGQHQMPYSQPMGAHQQFQARQLSGGHIQHSMSQGQLNPAMNRHLNQFSGGANSALFTSAQGSPSSQMIPNMSSMQSQTLVPRMQQFGVSGTNPQRSHSSQMLGDQMFNTSGMMQTQQTQIQQSQQQQQQQQQGGYGNMQTNQQSLQPNNMMQNAQQRHQNPQ
170
237
222
524










Molecular Recognition Features






MoRF SequenceStartStop




NANANA