<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31807

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMNGEYDYEDGAQHQDGARESAVAGASNTNQISTSFFPPPPQVYKKFTKRNLRYLEILNSHKLADDEPSWDLLSVTQRLERQNAILRQPGSSSKIDAEQLQDEEADMAAIQDQDCDKPMTDLPDFDLKAELEPPNVDWIEEDGGYTVFGQLWPIPDVTPTLQQLGIPVLYPLEGTDRKELLLTLLRTLLQTYREITGDLLKPAQPYDVWVPAVPDPNLTPEQQQQQMATNPGFWTQTTEAKDRLKHMQNVVVNMQFLINELRPVQAKETLKLIMQMQLERRKQEMQLIQERCATMRARVEELKKMLGKQSDCYGSS
Length315
PositionMiddle
OrganismUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Ustilago.
Aromaticity0.07
Grand average of hydropathy-0.689
Instability index45.07
Isoelectric point4.71
Molecular weight36076.39
Publications
PubMed=17080091

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
ECO:0000250
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.59|      11|      60|     152|     162|       2
---------------------------------------------------------------------------
  152-  162 (21.93/10.61)	PIPDVTPTLQQ
  213-  223 (22.66/11.18)	PDPNLTPEQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.58|      16|      23|     232|     254|       4
---------------------------------------------------------------------------
  235-  254 (20.15/27.67)	QTTEAKDRLKhmqnVVVNMQ
  261-  276 (26.43/11.67)	RPVQAKETLK....LIMQMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31807 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MNGEYDYEDGAQHQDGARESAVAGASNTNQISTSFFPPP
2) NAILRQPGSSSKIDAEQLQDEEADMAAIQDQDCDKPM
3) VPAVPDPNLTPEQQQQQMATNPGFWTQTTE
1
82
209
39
118
238










Molecular Recognition Features






MoRF SequenceStartStop




1) MNGEYDYED
2) QVYKKFTKRNLRYLEIL
1
41
9
57