<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31798

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP
Length233
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.04
Grand average of hydropathy-0.736
Instability index49.11
Isoelectric point5.50
Molecular weight27244.94
Publications
PubMed=9671713
PubMed=9989412
PubMed=15489334
PubMed=10235267
PubMed=15175163
PubMed=15989967
PubMed=17709345
PubMed=19369195
PubMed=25218447
PubMed=25114211
PubMed=25772364
PubMed=25755297
PubMed=28112733

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nuclear body	GO:0016604	IDA:HPA
nucleoplasm	GO:0005654	TAS:Reactome
transcription regulator complex	GO:0005667	IDA:MGI
ubiquitin ligase complex	GO:0000151	IEA:Ensembl

GO - Biological Function
transcription coactivator activity	GO:0003713	TAS:ProtInc
ubiquitin protein ligase activity	GO:0061630	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IDA:MGI
regulation of transcription initiation from RNA polymerase II promoter	GO:0060260	TAS:Reactome
stem cell population maintenance	GO:0019827	IEA:Ensembl
transcription initiation from RNA polymerase II promoter	GO:0006367	TAS:ProtInc









Interaction





Binary Interactions
[O43513<-->Q9Y376: CAB39]	NbExp=3	EBI-394632,EBI-306905
[O43513<-->A0A0S2Z4Q4: HGS]	NbExp=3	EBI-394632,EBI-16429135
[O43513<-->O14964: HGS]	NbExp=4	EBI-394632,EBI-740220
[O43513<-->Q15648: MED1]	NbExp=6	EBI-394632,EBI-394459
[O43513<-->Q9BTT4: MED10]	NbExp=7	EBI-394632,EBI-394354
[O43513<-->Q13503: MED21]	NbExp=3	EBI-394632,EBI-394678
[O43513<-->O95402: MED26]	NbExp=8	EBI-394632,EBI-394392
[O43513<-->Q9Y3C7: MED31]	NbExp=3	EBI-394632,EBI-394707
[O43513<-->P03383: env]	Xeno	NbExp=3,












Repeat regions





Repeats

>MDP31798
No repeats found











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31798 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRD
175
213










Molecular Recognition Features






MoRF SequenceStartStop




1) PMQYIKEYTD
14
23