Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MAEPGRTFNTAFAPPPPLWKHFTPENLQRLENIKKEASKGEDGRRRKKEWSPAELRSLKIPPELRFLVPPEIPSEQYSIFGEVQNLSTALPSLEEQGITQLYPSSPKPDTKSGDSSQPAQPLNHAYYLLKISKSLLLNFLEFVGILSVAPEQFEPKVEDIRNLFINAHHLLNLYRPHQARESLIMMMEAQLARTKDEIQQMDKLKEEVNAVLDQLAAEGADVGSTIQSTTKDKKGVKPEDQIPEDSKLLWDILDGKLDD |
Length | 259 |
Position | Middle |
Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.617 |
Instability index | 51.30 |
Isoelectric point | 5.32 |
Molecular weight | 29318.01 |
Publications | PubMed=16372000 PubMed=19146970 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IBA:GO_Central |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP31797 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 76.90| 22| 44| 87| 108| 1 --------------------------------------------------------------------------- 87- 108 (39.25/24.69) STALPSLEEQGITQLYPSSPKP 134- 155 (37.64/23.41) SLLLNFLEFVGILSVAPEQFEP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 74.42| 23| 36| 193| 215| 4 --------------------------------------------------------------------------- 193- 215 (35.83/24.70) RTKDEIQQMDKLKEEVNAVLDQL 231- 253 (38.59/27.14) KDKKGVKPEDQIPEDSKLLWDIL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) LWKHFTPENLQRLENIKK 2) PEDQIPEDSKLLWDILDGKLDD 3) RRRKKEW | 18 238 44 | 35 259 50 |
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