<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31795

Description Putative mediator of RNA polymerase II transcription subunit 7
SequenceMNTSQQQQQQQQQQQQQQQQQQQTPQQVENVSAFPPPPPFYKLYLNYKKDVDYSKPTTENSKKNDTPEGNESTIEKNIDNSDEMNIDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKATTSTNKKIELNKPLAPPLPPKVGANYVQFGQTYSTVDMLPSLDESGAKQLYPKGDIEPISELKKLNRSILFNYLQLLETLIENPKNYQSKIEDISLLFINFHHLLNSYRPHQARETLLSIMNEQIKQKNQSNESIKKALDICKESLMNSFKNLNIEDKQIDSATPLPTNITSPTKNLMSPTKLNNSQDVNMNENNDDDEDKEINWMDQLLDEMLKIN
Length345
PositionMiddle
OrganismDictyostelium discoideum (Slime mold)
KingdomAmoebozoa
LineageEukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales> Dictyosteliaceae> Dictyostelium.
Aromaticity0.05
Grand average of hydropathy-1.305
Instability index56.68
Isoelectric point4.97
Molecular weight39699.00
Publications
PubMed=15875012
PubMed=18515835

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). 
GO - Cellular Component
core mediator complex	GO:0070847	ISS:dictyBase
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	ISS:dictyBase
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.87|      15|      15|     103|     117|       2
---------------------------------------------------------------------------
  103-  117 (30.38/ 8.41)	NNNNNNNNNNNNNNN
  119-  133 (28.49/ 7.45)	NNNNNNNNKATTSTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.10|      25|      34|     180|     209|       3
---------------------------------------------------------------------------
  180-  209 (38.38/35.13)	PKGDIEPISELkklnrSILF.NYLQLL.........ETLI
  212-  246 (33.72/19.89)	PKNYQSKIEDI.....SLLFiNFHHLLnsyrphqarETLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.11|      11|     107|      35|      47|       5
---------------------------------------------------------------------------
   35-   47 (20.83/19.00)	PPPPPfyKLYLNY
  144-  154 (24.28/13.73)	PPLPP..KVGANY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.52|      12|      29|     274|     285|       7
---------------------------------------------------------------------------
  274-  285 (18.59/ 6.53)	LMNSFKNLNIED
  298-  309 (17.93/ 6.06)	ITSPTKNLMSPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31795 with Med7 domain of Kingdom Amoebozoa
Unable to open file!