<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31795
Description |
Putative mediator of RNA polymerase II transcription subunit 7 |
Sequence | MNTSQQQQQQQQQQQQQQQQQQQTPQQVENVSAFPPPPPFYKLYLNYKKDVDYSKPTTENSKKNDTPEGNESTIEKNIDNSDEMNIDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKATTSTNKKIELNKPLAPPLPPKVGANYVQFGQTYSTVDMLPSLDESGAKQLYPKGDIEPISELKKLNRSILFNYLQLLETLIENPKNYQSKIEDISLLFINFHHLLNSYRPHQARETLLSIMNEQIKQKNQSNESIKKALDICKESLMNSFKNLNIEDKQIDSATPLPTNITSPTKNLMSPTKLNNSQDVNMNENNDDDEDKEINWMDQLLDEMLKIN |
Length | 345 |
Position | Middle |
Organism | Dictyostelium discoideum (Slime mold) |
Kingdom | Amoebozoa |
Lineage | Eukaryota> Amoebozoa> Evosea> Eumycetozoa> Dictyostelia> Dictyosteliales>
Dictyosteliaceae> Dictyostelium.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -1.305 |
Instability index | 56.68 |
Isoelectric point | 4.97 |
Molecular weight | 39699.00 |
Publications | PubMed=15875012
PubMed=18515835
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors (By similarity).
ECO:0000250
|
GO - Cellular Component | core mediator complex GO:0070847 ISS:dictyBase
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 ISS:dictyBase
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP31795
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.87| 15| 15| 103| 117| 2
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103- 117 (30.38/ 8.41) NNNNNNNNNNNNNNN
119- 133 (28.49/ 7.45) NNNNNNNNKATTSTN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.10| 25| 34| 180| 209| 3
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180- 209 (38.38/35.13) PKGDIEPISELkklnrSILF.NYLQLL.........ETLI
212- 246 (33.72/19.89) PKNYQSKIEDI.....SLLFiNFHHLLnsyrphqarETLL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.11| 11| 107| 35| 47| 5
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35- 47 (20.83/19.00) PPPPPfyKLYLNY
144- 154 (24.28/13.73) PPLPP..KVGANY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 36.52| 12| 29| 274| 285| 7
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274- 285 (18.59/ 6.53) LMNSFKNLNIED
298- 309 (17.93/ 6.06) ITSPTKNLMSPT
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